Study of tRNA-Derived Fragment tRF-20-S998LO9D in Pan-Cancer

Ma, Jinqi; Liu, Fengxia

doi:10.1155/2022/8799319

Cited by 6 publications

(8 citation statements)

References 33 publications

(33 reference statements)

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“…Lastly, Onconase (ONC) is a small RNase that has great cellular uptake, resistance against RNase Inhibitors and a propensity for tRF-20-S998LO9D 5' tsRNA Correlates with tumour progression via an unknown mechanism [153] tsRNA-ValTAC-41 3' tRNA half Upregulated in patients with pancreatic adenocarcinoma and in exosomes of liver cancer patients [126,142] tsRNA-26576 Not classified Upregulated in breast cancer, proposed to promote cellular growth, and inhibit apoptosis [154] 5' tiRNA-Pro TGG 5' tRNA half Downregulated in colorectal adenocarcinoma patients and associated with poor patient survival; proposed to regulate several pathways (AMPK, MAPK and mTOR) [155] tsRNA-5001a Not classified Upregulated in lung adenocarcinoma tissue, promotes the proliferation of lung adenocarcinoma cells [156] AS-tDR-007872 5' tRNA half Downregulated in lung cancer patients and regulates apoptosis by downregulating BCL2L11 [157] targeting cancer cells [148]. Since the first clinical trial in 1993, ONC has been administered to cancer patients alone or in combination with other treatments [148].…”

Section: Tsrna-based Therapeutic Applicationsmentioning

confidence: 99%

An old friend with a new face: tRNA-derived small RNAs with big regulatory potential in cancer biology

Fazio

Gullerová

2023

Br J Cancer

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Transfer RNAs (tRNAs) are small non-coding RNAs (sncRNAs) essential for protein translation. Emerging evidence suggests that tRNAs can also be processed into smaller fragments, tRNA-derived small RNAs (tsRNAs), a novel class of sncRNAs with powerful applications and high biological relevance to cancer. tsRNAs biogenesis is heterogeneous and involves different ribonucleases, such as Angiogenin and Dicer. For many years, tsRNAs were thought to be just degradation products. However, accumulating evidence shows their roles in gene expression: either directly via destabilising the mRNA or the ribosomal machinery, or indirectly via regulating the expression of ribosomal components. Furthermore, tsRNAs participate in various biological processes linked to cancer, including apoptosis, cell cycle, immune response, and retroviral insertion into the human genome. It is emerging that tsRNAs have significant therapeutic potential. Endogenous tsRNAs can be used as cancer biomarkers, while synthetic tsRNAs and antisense oligonucleotides can be employed to regulate gene expression. In this review, we are recapitulating the regulatory roles of tsRNAs, with a focus on cancer biology.

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Section: Tsrna-based Therapeutic Applicationsmentioning

confidence: 99%

An old friend with a new face: tRNA-derived small RNAs with big regulatory potential in cancer biology

Fazio

Gullerová

2023

Br J Cancer

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“…By comprehensive characterization of TCGA datasets involving 80 primary UVM tumor samples, the expression profiles of miRNA isoforms and tRFs was described, with close relation to various molecular phenotypes, metastatic disease, and patient survival of UVM [ 175 ]. Recently, a 5’-tRF tRF-20-S998LO9D was retrieved through bioinformatics of MINTbase pan-cancer datasets and verified as upregulated in a variety of cancers, including BC, HNSCC, ccRCC, lung squamous cell carcinoma, pheochromocytoma and paraganglioma, and uterine corpus endometrial carcinoma [ 197 ]. The elevated expression of tRF-20-S998LO9D indicated poor prognosis in a variety of cancers and could be a potential pan-cancer biomarker [ 197 ].…”

Section: Biological Roles and Clinical Values Of Trfs In Cancermentioning

confidence: 99%

“…Recently, a 5’-tRF tRF-20-S998LO9D was retrieved through bioinformatics of MINTbase pan-cancer datasets and verified as upregulated in a variety of cancers, including BC, HNSCC, ccRCC, lung squamous cell carcinoma, pheochromocytoma and paraganglioma, and uterine corpus endometrial carcinoma [ 197 ]. The elevated expression of tRF-20-S998LO9D indicated poor prognosis in a variety of cancers and could be a potential pan-cancer biomarker [ 197 ].…”

Section: Biological Roles and Clinical Values Of Trfs In Cancermentioning

confidence: 99%

Emerging roles of tRNA-derived fragments in cancer

Wang

et al. 2023

Mol Cancer

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AbstracttRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of tRFs with critical functions in distinct physiological and pathophysiological processes. tRFs can regulate cell viability, differentiation, and homeostasis through multiple mechanisms and are thus considered as critical regulators of human diseases including cancer. In addition, increasing evidence suggest the extracellular tRFs may be utilized as promising diagnostic and prognostic biomarkers for cancer liquid biopsy. In this review, we focus on the biogenesis, classification and modification of tRFs, and summarize the multifaceted functions of tRFs with an emphasis on the current research status and perspectives of tRFs in cancer.

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“…In particular, tRFs are small microRNA (miRNA) sized molecules that play important regulatory and functional roles in various diseases [ 11 ]. Previous studies have suggested that tRFs may be implicated in cancer pathogenesis and proliferation and may act as biomarkers for cancer prognosis [ 12 , 13 ]. For instance, a study examining tRF expression across various cancers found that tRF-20-S998LO9D was differentially expressed in several cancers and was associated with reduced cell proliferation in LUSC [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of tRNA-Derived Fragments in Lung Squamous Cell Carcinoma with Respect to Tobacco Smoke

Magesh

Gande

Yalamarty

et al. 2023

IJMS

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Lung squamous cell carcinoma (LUSC) is a highly heterogeneous cancer that is influenced by etiological agents such as tobacco smoke. Accordingly, transfer RNA-derived fragments (tRFs) are implicated in both cancer onset and development and demonstrate the potential to act as targets for cancer treatments and therapies. Therefore, we aimed to characterize tRF expression with respect to LUSC pathogenesis and clinical outcomes. Specifically, we analyzed the effect of tobacco smoke on tRF expression. In order to do so, we extracted tRF read counts from MINTbase v2.0 for 425 primary tumor samples and 36 adjacent normal samples. We analyzed the data in three primary cohorts: (1) all primary tumor samples (425 samples), (2) smoking-induced LUSC primary tumor samples (134 samples), and (3) non-smoking-induced LUSC primary tumor samples (18 samples). Differential expression analysis was performed to examine tRF expression in each of the three cohorts. tRF expression was correlated to clinical variables and patient survival outcomes. We identified unique tRFs in primary tumor samples, smoking-induced LUSC primary tumor samples, and non-smoking-induced LUSC primary tumor samples. In addition, many of these tRFs demonstrated correlations to worse patient survival outcomes. Notably, tRFs in the smoking-induced LUSC and non-smoking-induced LUSC primary tumor cohorts were significantly correlated to clinical variables pertaining to cancer stage and treatment efficacy. We hope that our results will be used to better inform future LUSC diagnostic and therapeutic modalities.

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Study of tRNA-Derived Fragment tRF-20-S998LO9D in Pan-Cancer

Cited by 6 publications

References 33 publications

An old friend with a new face: tRNA-derived small RNAs with big regulatory potential in cancer biology

An old friend with a new face: tRNA-derived small RNAs with big regulatory potential in cancer biology

Emerging roles of tRNA-derived fragments in cancer

Characterization of tRNA-Derived Fragments in Lung Squamous Cell Carcinoma with Respect to Tobacco Smoke

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