Study of transcranial therapy 904 nm in experimental model of stroke

Fonseca, Eliane Gonçalves de Jesus; Pedroso, Ariele; Neuls, Débora; Barbosa, Danilo; Cidral-Filho, Francisco José; Salgado, Afonso Shiguemi Inoue; Dubiela, Angela; Carraro, Emerson; Kerppers, Ivo Ilvan

doi:10.1007/s10103-019-02758-9

Cited by 9 publications

(4 citation statements)

References 21 publications

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“…In addition, PBM restores mitochondrial dynamics and decreases both oxidative and activation of mitochondriadependent neuronal apoptosis [31]. As specified in the technical section, the dual-wavelength laser source (808 nm and 904 nm emissions) used is able to induce a variety of photobiostimulation effects, such as neurogenesis, muscle resistance, and animal motor behavior, described in in vitro and in vivo studies [32][33][34][35]. In particular, as previously reported, a pulsed emission (PW) rather than a continuous modality (CW) has the advantage to allow the use of elevated energy pulses avoiding side effects and to enable adequate therapeutic dose to more profound tissues.…”

Section: Discussionmentioning

confidence: 99%

NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia

et al. 2021

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Brain photobiomodulation (PBM) is an innovative treatment for a variety of neurological conditions, including cerebral ischemia. However, the capability of PBM for ischemic stroke needs to be further explored and its mechanisms of action remain currently unclear. The aim of the present research was to identify a treatment protocol capable of inducing neuroprotection and to investigate the molecular mechanisms activated by a dual-wavelength near infrared (NIR) laser source in an organotypic hippocampal slice model of hypoxia/ischemia. Hippocampal slices were exposed to oxygen and glucose deprivation (OGD) for 30 min followed by NIR laser light (fluence 3.71, 7.42, or 14.84 J/cm2; wavelengths 808 nm and 905 nm) delivered immediately or 30 min or 60 min after OGD, in order to establish a therapeutic window. Neuronal injury was assessed by propidium iodide fluorescence 24 h later. Our results show that NIR laser irradiation attenuates OGD neurotoxicity once applied immediately or 30 min after OGD. Western blot analysis of proteins involved in neuroinflammation (iNOS, COX-2, NFkB subunit p65, and Bcl-2) and in glutamatergic-mediated synaptic activity (vGluT1, EAAT2, GluN1, and PSD95) showed that the protein modifications induced by OGD were reverted by NIR laser application. Moreover, CA1 confocal microscopy revealed that the profound morphological changes induced by OGD were reverted by NIR laser radiation. In conclusion, NIR laser radiation attenuates OGD neurotoxicity in organotypic hippocampal slices through attenuation of inflammatory mechanisms. These findings shed light on molecular definition of NIR neuroprotective mechanisms, thus underlining the potential benefit of this technique for the treatment of cerebral ischemia.

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Section: Discussionmentioning

confidence: 99%

NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia

et al. 2021

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“…Recently, Kim et al developed an implantable multi-LED (630 nm) array, which could prevent tissue and functional impairment, and attenuated the cognitive decline in an acute ischemic stroke mouse model. 52 In addition, tPBM with wavelengths of 660, 56 780, 57 808, [58][59][60] and 904 61 nm also has beneficial effects of neuroprotection, anti-inflammation, and cognitive improvement in ischemic stroke rat models (including the middle cerebral artery occlusion model and the photothrombotic model). Oron et al found that tPBM in the CW mode could better improve the neurological score and promote the neurogenesis in ischemic stroke mice than tPBM in the pulsed irradiation.…”

Section: Tpbm For Ischemic Strokementioning

confidence: 99%

“…Notes: the data are summarized from Refs. 20–23 and 51–70, (ischemic stroke), 71–73 (HI), 74 (intracerebral hemorrhage), 25–28, 75–83 (AD), 29–34, 84–96 (PD), 97–99 (multiple sclerosis), 35–40, 100–116 (TBI), 117 (possible chronic traumatic encephalopathy), 41–44, 118–126 (depression), 45–50, 127...…”

Section: Introductionmentioning

confidence: 99%

Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends

Lin,

Li,

Zhu

et al. 2024

Neurophoton.

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The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood-brain barrier, limiting drug delivery to the central nervous system (CNS). Transcranial photobiomodulation (tPBM) is a promising technology for treating brain diseases, due to its effectiveness, non-invasiveness, and affordability. tPBM has been widely used in pre-clinical experiments and clinical trials for treating brain diseases, such as stroke and Alzheimer's disease. This review provides a comprehensive overview of tPBM. We summarize emerging trends and new discoveries in tPBM based on over one hundred references published in the past 20 years. We discuss the advantages and disadvantages of tPBM and highlight successful experimental and clinical protocols for treating various brain diseases. A better understanding of tPBM mechanisms, the development of guidelines for clinical practice, and the study of dose-dependent and personal effects hold great promise for progress in treating brain diseases.

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“…Another disadvantage of NIR laser neuromodulation is the accidental overheating of brain tissue, which may cause inherent injury and inhibit neural activity, producing side effects in addition to normal regulation. Similarly, NIR laser, as a relatively safe physical therapy, is suitable for patients with cerebral ischemic diseases (such as ischemic stroke and neonatal hypoxic-ischemic brain injury) and less used for hemorrhagic stroke to avoid adverse consequences [ 149 , 150 ]. Other studies have shown that high-power near-infrared light may cause retinal damage, and it is necessary to calculate the damage threshold temperatures and the maximum permissible exposure dose and time according to the individual situation [ 151 , 152 ].…”

Section: Limitationsmentioning

confidence: 99%

Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies

Pan

Liu

et al. 2023

J Transl Med

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Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various neuropathological conditions or diseases. Photobiomodulation therapy is a type of noninvasive physical therapy that is gradually emerging in the field of neuroscience. Transcranial photobiomodulation has been commonly used to regulate neural activity in the superficial cortex. To stimulate deeper brain activity, advanced photobiomodulation techniques in conjunction with photosensitive nanoparticles have been developed. This review addresses the mechanisms of photobiomodulation on neurons and neural networks and discusses the advantages, disadvantages and potential applications of photobiomodulation alone or in combination with photosensitive nanoparticles. Photobiomodulation and its associated strategies may provide new breakthrough treatments for cognitive improvement.

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Study of transcranial therapy 904 nm in experimental model of stroke

Cited by 9 publications

References 21 publications

NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia

NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia

Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends

Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies

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