Study of TNFα -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population

Bouhaha, R.; Baroudi, Thouraya; Ennafaa, Hajer; Vaillant, Emanuel; Abid, Haisam; Sassi, R.; Vatin, Vincent; Froguel, Philippe; Gaaied, Amel Benammar-El; Meyre, David; Vaxillaire, Martine

doi:10.1016/j.clinbiochem.2010.01.008

Cited by 44 publications

(32 citation statements)

References 32 publications

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“…In accordance with previous studies on T2DM [21][22][23][24][25][26][27][28][29][30], we found no association between TNF-α −308G/A polymorphism and T2DM. Although Heijmans et al reported that this polymorphism was associated with T2DM in Dutch people, their patients were aged 85 years and over, which suggests that age contributed to this result, because adverse effects of mild alterations in TNF-α expression become apparent only in old age [31].…”

Section: Discussionsupporting

confidence: 82%

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

et al. 2011

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Abstract. The association between some Tumor necrosis factor-alpha (TNF-α) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF-α gene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR-RFLP. We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07-2.29; p = 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DM when compared with controls (OR = 1.56, 95% CI: 1.05-2.31; p = 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.

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Section: Discussionsupporting

confidence: 82%

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

et al. 2011

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“…Additional studies [56, 57] assessing the long-term risk factors for type 2 diabetes revealed that the levels of CRP, IL-6, IL-8, and TNF- α were higher in diabetic populations than the normal population. These indexes levels increase gradually as syndromes evolve; in particular, the levels of those indexes of the dual deficiency of yin and yang symptom are higher than those of any other symptoms.…”

Section: Diabetic Patterns and Correlation Indicesmentioning

confidence: 99%

Syndrome Differentiation of Diabetes by the Traditional Chinese Medicine according to Evidence‐Based Medicine and Expert Consensus Opinion

Guo

Chen

Song

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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In Chinese medicine, diabetes belongs to the category of “Xiaoke disease (disease with symptoms of frequent drinking and urination)”; in the traditional sense, its pathogenesis is “Yin deficiency and dryness-heat.” However, over time, changes in the social environment and lifestyle have also changed the use of traditional Chinese medicine (TCM) in diabetes. In this study, we performed diabetes syndrome differentiation using TCM according to evidence-based medicine and expert consensus opinion.

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“…The expression of pro-and anti-inflammatory cytokines may be modulated by single nucleotide polymorphisms (SNPs) located in the regulatory regions of genes (15,16). Some studies have investigated the association among TNF-α, IL-6, and IL-10 gene polymorphisms with metabolic diseases (17)(18)(19)(20)(21)(22)(23)(24)(25). Despite these reports examining the association of inflammation markers and SNPs in cytokine genes, much controversy remains as to their role in diabetes occurrence (26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Introductionmentioning

confidence: 99%

IL-6, TNF-α, and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazilian individuals

Rodrigues

Pietrani

Bosco

et al. 2017

Arch. Endocrinol. Metab.

107

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Objective: This study aimed to investigate the association of plasma TNF-α, IL-6, and lL-10 levels and cytokine gene polymorphisms , and IL-10 (-1082 A→G, -819 T→C and -592 A→C)] in type 2 diabetes mellitus (T2DM) and obese patients. Subjects and methods: One hundred and two T2DM patients and 62 controls were included in this study. Cytokine plasma levels were measured by the Cytometric Bead Array method. Genotyping was carried out by the polymerase chain reaction. Results: IL-6 levels were significantly different between T2DM patients and controls. Interestingly, IL-6 levels were higher in T2DM patients with BMI > 30 kg/m 2 compared with other patients and obese controls. The genotype and allele frequencies were similar between patients and controls. In the T2DM group, the SNP IL-10 -819 T/C showed a difference between the cytokine level and genotypes: IL-10 level in the TT genotype was significantly higher when compared to CC genotype. Conclusions: These results suggest an association between IL-6 levels and obesity, and IL-10 levels and the SNP -819 T/C in T2DM. Knowledge of these variants in T2DM might contribute to a better understanding of the role of inflammation in the etiology and progression of this disease.

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Study of TNFα -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population

Cited by 44 publications

References 32 publications

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

Syndrome Differentiation of Diabetes by the Traditional Chinese Medicine according to Evidence‐Based Medicine and Expert Consensus Opinion

IL-6, TNF-α, and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazilian individuals

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