Study of TLR4 and IL-8 Gene Polymorphisms in<b><i>H.pylori</i></b>-Induced Inflammation in Gastric Cancer in an Ethnic Kashmiri Population

Qadri, Qurteeba; Rasool, Roohi; Afroze, Dil; Naqash, Sameer H.; Gulzar, Ghulam Mohammad; Yousuf, Adfar; Siddiqi, Mushtaq A.; Shah, Zafar A.

doi:10.3109/08820139.2013.854378

Cited by 34 publications

(25 citation statements)

References 31 publications

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“…Given that some authors have failed to show specific associations between polymorphisms in the TLR signaling pathway, especially in TLR2, TLR4 , and CD14 , and gastric precancerous lesions/GC (157, 160, 162, 164, 172, 174–178, 180–183, 185, 188, 189), we performed the first global meta-analysis to assess the role of TLR2, TLR4 , and CD14 polymorphisms in gastric carcinogenesis (155), in an attempt to clarify the limited and current conflicting evidence, and to establish the true impact of the TLR signaling pathway in GC. Our meta-analysis, which included 18 case–control studies conducted in Caucasian, Asian, and Latin American populations, showed that TLR4 Asp299Gly was a definitive risk factor for GC in Western populations (pooled OR: 1.87, 95% CI: 1.31–2.65).…”

Section: Toll-like Receptors and Helicobacter Pylori-related Gastric mentioning

confidence: 99%

Pattern-Recognition Receptors and Gastric Cancer

2014

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Chronic inflammation has been associated with an increased risk of several human malignancies, a classic example being gastric adenocarcinoma (GC). Development of GC is known to result from infection of the gastric mucosa by Helicobacter pylori, which initially induces acute inflammation and, in a subset of patients, progresses over time to chronic inflammation, gastric atrophy, intestinal metaplasia, dysplasia, and finally intestinal-type GC. Germ-line encoded receptors known as pattern-recognition receptors (PRRs) are critical for generating mature pro-inflammatory cytokines that are crucial for both Th1 and Th2 responses. Given that H. pylori is initially targeted by PRRs, it is conceivable that dysfunction within genes of this arm of the immune system could modulate the host response against H. pylori infection, and subsequently influence the emergence of GC. Current evidence suggests that Toll-like receptors (TLRs) (TLR2, TLR3, TLR4, TLR5, and TLR9), nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) (NOD1, NOD2, and NLRP3), a C-type lectin receptor (DC-SIGN), and retinoic acid-inducible gene (RIG)-I-like receptors (RIG-I and MDA-5), are involved in both the recognition of H. pylori and gastric carcinogenesis. In addition, polymorphisms in genes involved in the TLR (TLR1, TLR2, TLR4, TLR5, TLR9, and CD14) and NLR (NOD1, NOD2, NLRP3, NLRP12, NLRX1, CASP1, ASC, and CARD8) signaling pathways have been shown to modulate the risk of H. pylori infection, gastric precancerous lesions, and/or GC. Further, the modulation of PRRs has been suggested to suppress H. pylori-induced inflammation and enhance GC cell apoptosis, highlighting their potential relevance in GC therapeutics. In this review, we present current advances in our understanding of the role of the TLR and NLR signaling pathways in the pathogenesis of GC, address the involvement of other recently identified PRRs in GC, and discuss the potential implications of PRRs in GC immunotherapy.

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Section: Toll-like Receptors and Helicobacter Pylori-related Gastric mentioning

confidence: 99%

Pattern-Recognition Receptors and Gastric Cancer

2014

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“…As a result, it has been postulated that the presence of these mutations may influence the development of GI disease only within certain populations. 115 It is unknown whether other CXCL8 gene polymorphisms contribute to the development of certain GI diseases. Research to date examining the relationship between CXCL8 gene polymorphisms and GI disease has focused on the −251 region, and additional research is required to clarify whether polymorphisms at other sites also factor into susceptibility to GI inflammation or cancer.…”

Section: Cxcl8 Gene Polymorphismsmentioning

confidence: 99%

Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences

Cotton¹,

Platnich²,

Muruve³

et al. 2016

IJICMR

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“…Лише у 13-15 % пацієнтів повністю відновлюється СО шлунка піс-ля ЕТ, у решти роками спостерігаються запальні зміни, з них приблизно у чверті -виражені [10]. Перебіг постерадикаційного запалення визначається особливостями міжклітинних взаємодій запального інфільтрату і епітелію СО шлунка [11].…”

Section: обговорення результатів дослідженняunclassified

The dynamics of the morphological status of the gastric mucosa in the early post-eradication period in children

Личковська¹,

Гнатейко²,

Kech³

et al. 2016

ScienceRise

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Study of TLR4 and IL-8 Gene Polymorphisms inH.pylori-Induced Inflammation in Gastric Cancer in an Ethnic Kashmiri Population

Abstract: No correlation was found between the appearance of disease and HP infection or the presence of TLR4 and IL-8 gene polymorphisms and HP infection.

Cited by 34 publications

References 31 publications

Pattern-Recognition Receptors and Gastric Cancer

Pattern-Recognition Receptors and Gastric Cancer

Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences

The dynamics of the morphological status of the gastric mucosa in the early post-eradication period in children

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