Study of thyroid hormones effect on biochemical parameters of liver function in Iraqi patients

Abstract

This study was aimed to study the effect of thyroid hormones on some biochemical tests of liver function in Iraqi male patients and to study the relationship between them. A controlled study included 135 samples from patients and controls, group B, 45 patients with a liver disorder, and group C: 45 patients with a thyroid disorder, and group A: 45 healthy people (as the controls group). The study concluded that there were significant statistically significant differences for patients with liver disease, as well as for patients who suffer from abnormalities in the functions of the thyroid gland. For triiodothyronine (T3) and thyroxine (T4), there was clear importance and a slight impact for patients with liver disease. Because of the defect in the liver enzymes, this led to an increase in the TSB percentage, which increased significantly. Alkaline and Albumin levels indicate statistical significance within the results of our study. Serum protein levels had no significant changes in our study.

Correlation Between Thyroid-Stimulating Hormone (TSH) and Liver Function Test Values in North Karnataka Patients Admitted to a Tertiary Care Hospital

“…A recent study by Jaafer et al (2023) [ 6 ] did not show any correlation between TSH, liver enzymes, or serum protein levels. The results of our study conform to the results of Jaafer et al (2023) [ 6 ]. Hypothyroidism and hyperthyroidism significantly affect thyroid function tests.…”

“…Literature shows a positive association between thyroid hormones and liver function parameters [2][3][4][5]. A recent study by Jaafer et al ( 2023) [6] did not show any correlation between TSH, liver enzymes, or serum protein levels. The results of our study conform to the results of Jaafer et al (2023) [6].…”

“…People with underactive (hypothyroidism) or overactive (hyperthyroidism) thyroids can have abnormal liver enzyme levels. Studies by Ajala et al (2013) [ 2 ], Codruta et al (2015) [ 3 ], Sangamesh et al (2020) [ 4 ], Yadav et al (2013) [ 5 ], and Jaafer et al (2023) [ 6 ] have shown connections between liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)) and thyroid function.…”

Unveiling Antioxidant and Antiproliferative Effects of Prosopis juliflora Leaves against Human Prostate Cancer LNCaP Cells

“…Several studies have reported an important role of the Bcl-2 family protein in the regulation of apoptosis and cell survival (50). In this regard, the effect of medicinal plants has also been considered (51)(52)(53)(54)(55)(56)(57)(58)(59)(60). In further elucidating the molecular mechanism of PJME-induced apoptosis, the mRNA expression of Bax, Bcl-2 and caspase-3 genes were measured.…”