Study of three patients with thrombotic thrombocytopenic purpura exchanged with solvent/detergent-treated plasma: Is its decreased protein S activity clinically related to their development of deep venous thromboses?

Photochemically treated fresh frozen plasma for transfusion of patients with acquired coagulopathy of liver disease

“…16 It has been reported that solvent/detergent-treated plasma has diminished levels of some antithrombotic proteins. 30,31 Because of concerns regarding this complication, the levels of antithrombotic proteins in PCT-FFP and in the plasma of postoperative patients were measured during this study. The incidence of HAT was comparable between treatment groups, and the levels of antithrombotic proteins in PCT-FFP and C-FFP were similar, as were the levels in patient plasma.…”

Solvent/detergent-treated plasma: a tale of 30 years of experience

“…Finally, the citrate concentration in the American product was lower and it had almost no PS activity, whereas European S/D plasma has a moderate reduction of PS activity and antigen [28]. All these differences could have been responsible for the adverse effects reported after the use of S/D plasma produced in the USA, which caused its withdrawal from the market after six deaths for thromboembolic complications in liver-transplanted patients and three cases of deep vein thrombosis in TTP patients plasma-exchanged using S/D plasma [28,29]. On the other hand, in Europe, there have been no reports of thromboembolic episodes directly related to S/D plasma treatment.…”

Virus-Safe Products: Pathogen Reduction and Inactivation

“…108 Mast and co-workers confirmed that SD-FFP has markedly reduced levels of the antithrombotic proteins antiplasmin and antitrypsin and that these reduced levels are due to conformational changes induced by detergent treatment. 111,112 The SD process utilizes pooled plasma from 100 to 2500 donors and is not amenable to a single-unit viral inactivation process. 111,112 The SD process utilizes pooled plasma from 100 to 2500 donors and is not amenable to a single-unit viral inactivation process.…”