Study of the UV protective and antibacterial properties of aqueous polyurethane dispersions extended with low molecular weight chitosan

Muzaffar, Shazia; Bhatti, Ijaz Ahmad; Zuber, Mohammad; Bhatti, Haq Nawaz; Shahid, Muhammad

doi:10.1016/j.ijbiomac.2016.09.106

Cited by 20 publications

(9 citation statements)

References 39 publications

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“…37 C-H symmetric stretching vibrations of CH 2 at about 2880 cm −1 as well as C-O-C stretching vibrations at about 1070 cm −1 are clearly visible too. 38 Vibrations at roughly 1560 and 1400 cm −1 , characteristic for the amide groups of ChOSL, were also recorded. 37 The most pronounced, sharp band in the spectrum of derivative A (Figure 2c) at 1731 cm −1 originates from the vibration of the C 17 carbonyl group.…”

Section: Resultsmentioning

confidence: 99%

Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells

et al. 2018

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Low targeting efficiency and fast metabolism of antineoplastic drugs are hindrances to effective chemotherapies and there is an ongoing search for better drugs, but also better carriers. Steroid derivatives, 3β-hydroxy-16-hydroxymino-androst-5-en-17-one (A) and 3β,17β-dihydroxy-16-hydroxymino-androst-5-ene (B) as cancer growth inhibitors were chemically synthesized and captured in a carrier composed of hydroxyapatite (HAp) nanoparticles coated with chitosan oligosaccharide lactate (ChOLS). The only difference between the two derivatives is that A has a carbonyl group at the C17 position of the five-membered ring and B has a hydroxyl. This small difference in the structure resulted not only in different physicochemical properties of the A- and B-loaded HAp/ChOSL, but also in different biological activities. The morphology of drug-loaded HAp/ChOSL particles was spherical, but the size depended on the drug identity: d50=138 nm for A-loaded HAp/ChOSL and d50=223 nm for B-loaded HAp/ChOSL. Cell-selective toxicity was tested against human breast carcinoma (MCF7 and MDA-MB-231), human lung carcinoma (A549) and human lung fibroblasts (MRC-5). The small selectivity of pure derivatives A and B toward breast cancer cells became drastically increased when they were delivered using HAp/ChOSL particles. Whereas the ratio of the cytotoxicity imposed onto breast cancer cells and the cytotoxicity imposed onto healthy MRC-5 fibroblasts ranged from 1.5 to 1.7 for pure A and from 1.5 to 2.3 for pure derivative B depending on the concentration, it increased to 5.4 for A-loaded HAp/ChOSL and 5.1 for B-loaded HAp/ChOSL. FACS analysis demonstrated poor uptake of HAp/ChOSL particles by MCF7 cells, suggesting that the drug release occurs extracellularly. The augmented activity of the drugs was most likely due to sustained release, although the favorable positive charge of the carrier, allowing it to adhere to the negatively charged plasma membrane and release the drugs steadily and directly to the hydrophobic cell membrane milieu, was delineated as a possible complementary mechanism.

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Section: Resultsmentioning

confidence: 99%

Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells

et al. 2018

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“…A good example in this field is the use of polyurethane dispersions extended with low molecular-weight chitosan. 38 Several papers have been published recently that are related to natural dyes or extracts from natural materials and their use for UV-protective applications. [39][40][41] The disadvantages of these systems are that, similarly, they introduce strong coloration, and also the low UV stability of the natural substances themselves.…”

Section: Hoque and Mahltigmentioning

confidence: 99%

“…Besides the use of inorganic materials, a second recent trend is the use of bio‐based materials for realisation of UV‐protective textiles. A good example in this field is the use of polyurethane dispersions extended with low molecular‐weight chitosan 38 . Several papers have been published recently that are related to natural dyes or extracts from natural materials and their use for UV‐protective applications 39‐41 .…”

Section: Introductionmentioning

confidence: 99%

Realisation of polyester fabrics with low transmission for ultraviolet light

Hoque

Mahltig

2020

Coloration Technology

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“…Kai Liu [ 29 ] modified polyurethane with lysozyme. Shazia Muzaffar [ 30 ] modified polyurethane with low molecular weight chitosan. In addition, TNO is also a good antibacterial agent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Properties of Antibacterial Polyurethanes

Duan

Jiang

2022

Polymers

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Novel physically crosslinked polyurethane (PUII), based on isophorone diisocyanates, was prepared by a conventional two-step method. The chemical structures of the PUII were characterized by fourier transform infrared (FTIR), proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), scanning electron microscopy (SEM) and DSC. The PUII hydrogels were subjected to solvent-induced self-assembly in THF + water to construct a variety of morphologies. The self-assembly morphology of the PUII was observed by scanning electron microscopy (SEM). The PUII films with different amounts (0.2%, 0.4%, 0.6%, 0.8%, 1.0%) of 1,3,5-Tris(2-hydroxyethyl)hexahydro-1,3,5-triazine (TNO) were challenged with Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Gray mold. The results showed that when a small amount of antibacterial agent were added, the antibacterial effect of films on Botrytis cinerea was more obvious. The mechanical evaluation shows that the antimicrobial polyurethane films exhibit good mechanical properties.

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Study of the UV protective and antibacterial properties of aqueous polyurethane dispersions extended with low molecular weight chitosan

Cited by 20 publications

References 39 publications

Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells

Chitosan oligosaccharide lactate coated hydroxyapatite nanoparticles as a vehicle for the delivery of steroid drugs and the targeting of breast cancer cells

Realisation of polyester fabrics with low transmission for ultraviolet light

Synthesis, Characterization and Properties of Antibacterial Polyurethanes

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