Study of the Types of Refractive Disturbances Obseved during Hyperglycemia in Humans

Aki, Angue Tatiana Harly Mba; Essone, Jean Fidèle Nnang; Ngaila, Nesta Ziza; Nsame, Daniella; Akoma, Muriel Obono; Matsanga, Olive Rosine; Abessolo, Félix Ovono

doi:10.4236/ojoph.2022.122014

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Other studies also reported that CCT, corneal curvature, and corneal asphericity in both types of diabetes were not different from the non-diabetic group [13,[34][35] . Inconsistent with our results, studies have shown that in diabetic patients the cornea is thicker than the non-diabetic group [14,[36][37] . In a study, maximum keratometry was steeper in the diabetic group than the non-diabetic group, and Rmin was different between the two groups [13] .…”

Section: Resultssupporting

confidence: 90%

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Narooie-Noori¹,

Mirzajani²,

Jafarzadehpur³

et al. 2023

Int J Ophthalmol

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AIM: To compare anterior segment parameters between two groups of type 2 diabetic with and without diabetic retinopathy (DR) and non-diabetic elderly subjects based on hemoglobin A1c (HbA1c) levels and status of DR. METHODS: This study was conducted on 997 residents aged 60y or over in Tehran, Iran. Diabetic group had HbA1c level ≥6.4% with no other systemic problems. The non-diabetic participants had normal eye findings and no systemic diseases. K1, K2, mean K, Q-value, anterior, central, posterior, and total corneal densitometric findings, anterior chamber volume (ACV), anterior chamber depth (ACD), corneal volume (CV), and pachymetry were measured by Pentacam AXL. RESULTS: A total of 678 non-diabetic (39% male) and 319 diabetic (35% male) subjects with mean age of 66.31±5.23 and 67.22±4.96y were examined, respectively. No statistically significant difference was found in anterior segment parameters between non-diabetic and diabetic groups (all P>0.05). However, middle, posterior, and total corneal densitometric values were statistically different between two groups after controlling the effects of confounders (P=0.014, 0.007, and 0.042, respectively). Corneal densitometric values in all layers, ACD, and ACV were different between diabetic subjects with and without DR (all P<0.05). In the diabetic group, only corneal densitometric values had a negative relationship with fasting blood sugar (P<0.001). ACD and ACV had a negative correlation with HbA1c levels (all P<0.05, r=-0.129 and -0.146, respectively). However, the relationships were not observed after controlling the confounders (P=0.938, 0.466, respectively). CONCLUSION: Considering the higher densitometric values of the cornea and lower ACD and ACV in diabetic subjects with DR, it is suggested that the examiners should perform comprehensive retinal examinations when faced with such conditions.

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Section: Resultssupporting

confidence: 90%

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Narooie-Noori¹,

Mirzajani²,

Jafarzadehpur³

et al. 2023

Int J Ophthalmol

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Complementary Approaches to Retinal Health Focusing on Diabetic Retinopathy

Rák,

Kovács-Valasek,

Pöstyéni

et al. 2023

Cells

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Diabetes mellitus affects carbohydrate homeostasis but also influences fat and protein metabolism. Due to ophthalmic complications, it is a leading cause of blindness worldwide. The molecular pathology reveals that nuclear factor kappa B (NFκB) has a central role in the progression of diabetic retinopathy, sharing this signaling pathway with another major retinal disorder, glaucoma. Therefore, new therapeutic approaches can be elaborated to decelerate the ever-emerging “epidemics” of diabetic retinopathy and glaucoma targeting this critical node. In our review, we emphasize the role of an improvement of lifestyle in its prevention as well as the use of phytomedicals associated with evidence-based protocols. A balanced personalized therapy requires an integrative approach to be more successful for prevention and early treatment.

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Study of the Types of Refractive Disturbances Obseved during Hyperglycemia in Humans

Cited by 2 publications

References 18 publications

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Complementary Approaches to Retinal Health Focusing on Diabetic Retinopathy

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