Study of the thermodynamics and mass transfer kinetics of two enantiomers on a polymeric imprinted stationary phase

Sajonz, Peter; Kele, Marianna; Zhong, Guoming; Sellergren, Börje; Guiochon, Georges

doi:10.1016/s0021-9673(98)00247-7

Cited by 153 publications

(133 citation statements)

References 26 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…A quantitative analysis of the mass transfer kinetic data derived from the experimental breakthrough curves 7 was first carried out. Some kinetic parameters were calculated from the resultant values of km,L.…”

Section: Resultsmentioning

confidence: 99%

“…In this study, an attempt was made to interpret the positive concentration dependence of km,L in the enantiomeric separation of L-and D-PA on a polymeric stationary phase imprinted with L-PA. 7 In this part, we report only the information on the experimental conditions which is necessary to understand the analytical results presented in this paper. Other details on the experimental work can be found in the original paper.…”

Section: Methodsmentioning

confidence: 99%

“…7 Sellergren and Shea 23 measured a swelling factor of 2.01 ml ml -1 for the L-PA imprinted stationary phase, indicating that the volume of the swollen particles is about twice as large as that of the dry ones. They also reported that the pore volume and BET surface area of the polymeric stationary phase were very small under dry conditions.…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

“…6,20 In this study, the Bi-Langmuir and the Freundlich isotherms and the lumped kinetic model were applied to the analysis of the adsorption equilibrium and the mass transfer kinetics, respectively. The details of the models can be found in the original paper 7 and in the literature cited. 6 …”

Section: Theorymentioning

confidence: 99%

“…Equation (7) is similar to the plate height equation obtained in The lumped mass transfer rate coefficient As described earlier in an experimental study, 7 the value of km,L was determined from experimental breakthrough curves. The contribution of axial dispersion to band broadening is also included in km,L.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Kinetic Study of the Concentration Dependence of the Mass Transfer Rate Coefficient in Enantiomeric Separation on a Polymeric Imprinted Stationary Phase

Miyabe

Guiochon

2000

ANAL. SCI.

Self Cite

View full text Add to dashboard Cite

Molecular imprinting is a most attractive method of preparation of dedicated stationary phases for chromatography. Its use for enantioseparations is attracting considerable interest. 1,2 Imprinted materials can provide a very high selectivity for the objective compound, i.e., the imprinted molecule. [1][2][3][4][5] Although analytical applications are rapidly developing, the situation on the preparative front is less rosy. 1 Columns packed with imprinted stationary phases exhibit a poor efficiency and elution peaks are often unsymmetrical, especially for the more retained enantiomer. Sellergren et al. 1,2 suggested that the nonlinear behavior of the adsorption isotherm was the main cause of the broad and unsymmetrical bands observed for L-phenylalanine anilide (PA) on an L-PA imprinted chiral stationary phase. Although the possibility of a slow mass transfer kinetics was also pointed out, no detailed study supported this assumption. Yet, information on the mass transfer characteristics of imprinted stationary phases is necessary to clarify strategies for the improvement of these materials.Most kinetic studies in chromatography assume that four mass transfer processes are involved in a column, (1) axial dispersion, (2) fluid-to-particle mass transfer, (3) intraparticle diffusion, and (4) adsorption/desorption. 6 The contributions of these four processes to peak spreading are evaluated separately. Axial dispersion and the fluid-to-particle mass transfer resistance are inherent to flow processes through packed beds. They are well understood, relatively easy to control, and their contributions are often small. By contrast, intraparticle diffusion and adsorption/desorption give often larger contributions to the mass transfer resistance in the column. Their properties are intrinsic to each packing material and they are still often poorly understood. In order to evaluate the actual performance of packing materials, the characteristics of the mass transfer kinetics inside stationary phase particles must be clarified.Sajonz et al. 7 measured the adsorption equilibrium isotherm and the mass transfer kinetics of L-and D-PA on a polymeric stationary phase imprinted with L-PA, using a staircase frontal analysis method. The isotherm was well represented by either the Bi-Langmuir or the Freundlich models, but not by the simple Langmuir isotherm. The equilibrium data suggested that the distribution of the adsorption energy on the surface of the imprinted stationary phase is heterogeneous and showed that this phase has a high selectivity for the imprinted L-enantiomer. The lumped mass transfer rate coefficient (km,L) was calculated from each single breakthrough curve by applying the transport model of chromatography. 6 The values of km,L increased with increasing concentration of the enantiomers. The extent of the positive concentration dependence of km,L was larger for L-PA than for D-PA. It is expected that a more detailed analysis of the overall mass transfer rate parameter, km,L, could provide new, useful information and all...

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Chromatographic Conditionsmentioning

confidence: 99%

Section: Theorymentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Kinetic Study of the Concentration Dependence of the Mass Transfer Rate Coefficient in Enantiomeric Separation on a Polymeric Imprinted Stationary Phase

Miyabe

Guiochon

2000

ANAL. SCI.

Self Cite

View full text Add to dashboard Cite

show abstract

Molecular Imprinting

Spivak¹

2010

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

Molecularly imprinted polymers (MIPs) are analytical materials that have widespread use for applications in the biomedical, analytical, chemical and biological sciences. Molecular imprinting is a process where a polymer, or other material, is formed around a template molecule. In this way, MIPs are tailored for specific recognition of the template molecule or related analogs and provide molecular recognition functions similar to antibodies and enzymes. Advantages of molecularly imprinted materials lie in the durability, relatively inexpensive cost, and ease of formation of network peptide polymers. This is in contrast to the problems of biomolecules that are unstable, generally expensive and often difficult and time consuming to obtain (usually from animal sources). Furthermore, the imprinted polymers are formed as network polymer solids that are predisposed for application as solid supports for HPLC, GC, sensors, and membranes. The robustness of the solid also affords stability in organic solvents, under harsh conditions such as heat or pressure, and gives MIPs a shelf life of many years. While the basic concepts of molecular imprinting are easy to understand, there are many important details that give further insight to obtaining the best performance in MIPs. This review covers many of these details and provides examples for greater insight into the method of molecular imprinting.

show abstract

Separation of Enantiomers Using Molecularly Imprinted Polymers

Sellergren

2006

Chiral Separation Techniques

View full text Add to dashboard Cite

Study of the thermodynamics and mass transfer kinetics of two enantiomers on a polymeric imprinted stationary phase

Cited by 153 publications

References 26 publications

Kinetic Study of the Concentration Dependence of the Mass Transfer Rate Coefficient in Enantiomeric Separation on a Polymeric Imprinted Stationary Phase

Kinetic Study of the Concentration Dependence of the Mass Transfer Rate Coefficient in Enantiomeric Separation on a Polymeric Imprinted Stationary Phase

Molecular Imprinting

Separation of Enantiomers Using Molecularly Imprinted Polymers

Contact Info

Product

Resources

About