2001
DOI: 10.1104/pp.125.4.1688
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Study of the Role of Antimicrobial Glucosinolate-Derived Isothiocyanates in Resistance of Arabidopsis to Microbial Pathogens

Abstract: Crude aqueous extracts from Arabidopsis leaves were subjected to chromatographic separations, after which the different fractions were monitored for antimicrobial activity using the fungus Neurospora crassa as a test organism. Two major fractions were obtained that appeared to have the same abundance in leaves from untreated plants versus leaves from plants challenge inoculated with the fungus Alternaria brassicicola. One of both major antimicrobial fractions was purified to homogeneity and identified by 1 H n… Show more

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Cited by 303 publications
(269 citation statements)
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“…Similarly, flavonoids also disrupt the fluidity of the microbial membranes 27 . In addition to these, Camelina seeds accumulate significant levels of glucosinolates, which are derived from amino acids biosynthesis and are responsible for their bitter taste and act as natural pesticides against various pathogens 16 . They are further converted by the endogenous thioglucosidase myrosinase into isothiocyanates (ITCs) and nitriles that inhibit and kills pathogens 16 .…”
Section: Resultsmentioning
confidence: 99%
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“…Similarly, flavonoids also disrupt the fluidity of the microbial membranes 27 . In addition to these, Camelina seeds accumulate significant levels of glucosinolates, which are derived from amino acids biosynthesis and are responsible for their bitter taste and act as natural pesticides against various pathogens 16 . They are further converted by the endogenous thioglucosidase myrosinase into isothiocyanates (ITCs) and nitriles that inhibit and kills pathogens 16 .…”
Section: Resultsmentioning
confidence: 99%
“…In addition to these, Camelina seeds accumulate significant levels of glucosinolates, which are derived from amino acids biosynthesis and are responsible for their bitter taste and act as natural pesticides against various pathogens 16 . They are further converted by the endogenous thioglucosidase myrosinase into isothiocyanates (ITCs) and nitriles that inhibit and kills pathogens 16 . Also, Camelina seed contains exceptionally high level of omega-3 fatty acids and antioxidants such as tocopherols, syringaldehyde and many more 15,28 as second line of plant defence mechanisms.…”
Section: Resultsmentioning
confidence: 99%
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“…Glucosinolates may have specific repellent or anti-nutritional effects on specific classes of insects and microorganisms. Some in vitro studies demonstrated that glucosinolate degradation products, isothiocyanates and nitriles, inhibited fungal and bacterial pathogen growth (Brader et al, 2001;Tierens et al, 2001). In Arabidopsis, over expression of CYP79D2 from cassava increased accumulation of isopropyl and methylpropyl aliphatic glucosinolates and transformed plants showed enhanced resistance against a bacterial soft-rot disease (Brader et al, 2006).…”
Section: Aliphatic Glucosinolatesmentioning
confidence: 99%
“…Arabidopsis ecotype lines accumulating methylsulfinyl GS were more resistant to the generalist caterpillar Spodoptera exigua (Hübner) and to the specialist caterpillar Pieris brassicae (L.) than the lines containing hydroxypropyl GS as main compounds (Rohr et al, 2006). 4-Methylsulphinylbutyl isothiocyanate was found to inhibit a wide range of fungi and bacteria (Tierens et al, 2001). Increased accumulation of aromatic GSs was shown to stimulate salicylic acid (SA)-mediated defenses, while suppressing jasmonic acid (JA)-dependent defenses (Brader et al, 2006).…”
Section: Introductionmentioning
confidence: 99%