Study of the retention behavior of newly synthesized<i>s</i>-triazine derivatives in RP TLC systems, and the lipophilicity of the compounds

Perišić-Janjić, Nada U.; Jovanović, Bratislav Ž.; Janjić, Nataša; Rajković, Olga S.; Antonović, Dušan

doi:10.1556/jpc.16.2003.6.4

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…10 (HPTLC technique, amino plate, acetonitrile as modifier) has worse correlation coefficients, and therefore seems to be unsuitable for comparison. However, it was previously shown [14] that lipophilicity parameters were determined using amino HPTLC plates, and logP have a parabolic relationship with logP, whilst the others (determined on C18 and cyano plates) are linear.…”

Section: Discussionmentioning

confidence: 99%

“…Cluster C beside objects 2 and 6 contains object no 7. The samples dendogram reveals two member sub-clusters of similar systems (1,5), (2,6), (3,14) and (9,11) which is an indication for existence of high degree of similarity.…”

Section: Pca and Hca Of (Chromatographic) Lipophilicity Parametersmentioning

confidence: 97%

“…The first group is characterized by negative values of PC1: chromatographic systems with acetonitrile as a mobile phase modifier and covalently bonded hydrocarbons as a stationary phase (C-18 and C-8), regardless of chromatographic technique (HPTLC, HPLC and OPLC) (objects 3,[12][13][14].…”

Section: Pca and Hca Of (Chromatographic) Lipophilicity Parametersmentioning

confidence: 99%

“…Clustering of different chromatographic systems in HCA (Figure 3) includes cluster A, B and C. Cluster B contains already mentioned objects with negative PC1 values (3,(12)(13)(14). In reversed phase HPLC, the solvent most frequently used as an organic modifier apart from acetonitrile is methanol.…”

Section: Pca and Hca Of (Chromatographic) Lipophilicity Parametersmentioning

confidence: 99%

“…Previous studies [14][15][16] showed that various chromatographic techniques and systems may be suitable for expressing the lipophilicity of these compounds. From the other side, the variety of LC stationary phases and mobile phases which has been used resulted in a range of various chromatographic lipophilicity scales.…”

Section: Introductionmentioning

confidence: 99%

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Chemometric characterization of (chromatographic) lipophilicity parameters of newly synthesized s‐triazine derivatives

Djaković‐Sekulić

Smoliński

Perišić-Janjić

et al. 2008

Journal of Chemometrics

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A (chromatographic) lipophilicity parameters of newly synthesized 2,4-bis(substituted)-6-chloro-s-triazines were studied. PCA-HCA were performed in order to classify and organize various chromatographic lipophilicity parameters that were determined by using different stationary and mobile phases and by various chromatographic techniques. The PCA-HCA indicates that for the set of investigated compounds, similar lipophilicity scales are given by chromatographic systems with covalently bonded hydrocarbons as a stationary phase and acetonitrile as a mobile phase modifier. Another cluster of lipophilicity scales forms cyano and octadecylsilica stationary phases with dioxane or tetrahydrofuran as a mobile phase modifiers. The general arrangement of investigated compounds along PC1 was according to the increase in lipophilicity forming two clusters (one of lower and the other of higher lipophilicity). PCA study of R M values underline the differences concerning solvent fraction. Also reveal that HPTLC systems on amino plates are distinguishable from the cyano and octadecylsilica supports, which were similar.

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Section: Discussionmentioning

confidence: 99%

Section: Pca and Hca Of (Chromatographic) Lipophilicity Parametersmentioning

confidence: 97%

Section: Pca and Hca Of (Chromatographic) Lipophilicity Parametersmentioning

confidence: 99%

Section: Pca and Hca Of (Chromatographic) Lipophilicity Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemometric characterization of (chromatographic) lipophilicity parameters of newly synthesized s‐triazine derivatives

Djaković‐Sekulić

Smoliński

Perišić-Janjić

et al. 2008

Journal of Chemometrics

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Pharmacokinetics and Toxicity Predictors of New s-Triazines, Herbicide Candidates, in Correlation with Chromatogrpahic Retention Constants

Milosevic¹,

Janjić²,

Milić³

et al. 2014

J. Agric. Food Chem.

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Herbicides, which are ubiquitously present in soil and food, have been proven to cause human health hazard effects, hence development of new herbicide-active compounds is recommended. In this paper, nine 2,4-bis(cycloalkyl)-6-chloro-s-triazines were considered as herbicide candidates and their pharmacokinetics and toxicity were reviewed on the basis of in silico descriptors. Both, pharmacokinetic and toxicity predictors were presented as functions of their lipophilicity, quantified with retention constants that were obtained by liquid chromatography. None of the candidates investigated has functional groups for genotoxicity hazards and endocrine disruptions; they have acceptable toxicity and favorable pharmacokinetic properties based on computer-aided analyses. Two candidates have been selected as lead compounds for further research.

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Unconventional TLC systems in lipophilicity determination: A review

Wicha-Komsta¹,

Komsta

2017

Journal of Liquid Chromatography & Related Technologies

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Study of the retention behavior of newly synthesizeds-triazine derivatives in RP TLC systems, and the lipophilicity of the compounds

Cited by 11 publications

References 9 publications

Chemometric characterization of (chromatographic) lipophilicity parameters of newly synthesized s‐triazine derivatives

Chemometric characterization of (chromatographic) lipophilicity parameters of newly synthesized s‐triazine derivatives

Pharmacokinetics and Toxicity Predictors of New s-Triazines, Herbicide Candidates, in Correlation with Chromatogrpahic Retention Constants

Unconventional TLC systems in lipophilicity determination: A review

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