Study of the Relationship between Chemical Structure and Antimicrobial Activity in a Series of Hydrazine-based Coordination Compounds

Abstract

The dependence of antimicrobial activity on the structure of compounds is studied in a series of compounds based on hydrazine coordinated with ions of Cu(II), Ni(II) and Pd(II). The study has been carried out by means of the original electron-topological method developed earlier. A molecular fragment has been found that is only characteristic of biologically active compounds. Its spatial and electron parameters have been used for the quantitative assessment of the activity in view. The results obtained can be used for the antimicrobial activity prediction in a series of compounds with similar structures.

Synthesis and Conformational Assignment of N-(E)-Stilbenyloxymethylenecarbonyl-Substituted Hydrazones of Acetone ando-(m- andp-) Chloro- (nitro-) benzaldehydes by Means of and NMR Spectroscopy

“…e N-substituted hydrazones of aldehydes are of interest because of their biological and pharmacological activities [1][2][3][4][5], as well as considerable chelating power with transition metals [6][7][8][9]. ey can be used in analytical chemistry to cover and analyze metals selectively as hydrazone complexes.…”