Study of the Relation between Il-6, Insulin Resistance, and Blood Pressure in Essential Hypertensive Patients

Elsayed, Amira M.; lbrahim, Walaa M.; Grawesh, Sayed A.; Elbadawy, Ayman

doi:10.21608/ejhm.2022.239183

Cited by 4 publications

(2 citation statements)

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“…A statistically significant inverse relationship could be observed between serum IL-6 and eGFR. Elsayed et al [21] study aimed to show a plausible connection between IL-6 levels, insulin resistance, and essential hypertension. IL-6 concentrations in HTN group were significantly greater than in control group (mean ± SD = 5.99 ± 0.84 pg/ml and 1.35±0.38 pg/ml, respectively).…”

Section: Discussionmentioning

confidence: 99%

Study of Serum Omentin-1 and IL-6 in Patients with Obesity, Hypertension and Hypertensive Nephropathy

2024

The Egyptian Journal of Hospital Medicine

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Background: The pathogenesis of hypertension (HTN) relates to immune system as well as inflammatory indicators such C-reactive protein, . Objective: To ascertain the connection between serum omentin-1 and IL-6 in obese, hypertensive and in hypertensive nephropathy patients. Patients and Methods: This casecontrol research was done on 126 patients between 18 and 60 years of age, both sexes, hypertensive patients, hypertensive nephropathy patients, and overweight obese subjects. Serum omentin-1 and serum IL-6 were quantified in all patients. Results: A statistically significant inverse relation was noted between serum omentin-1 and age, systolic, diastolic blood pressure, urea, creatinine. A statistically significant positive relation has been observed between serum omentin-1 and estimated glomerular filtration rate (eGFR). The best cutoff points of serum omentin-1 and IL-6 for diagnosis stage III and IV hypertensive nephropathy respectively was ≤215, ≥6.7 with area under curve 0.721, 0.785, sensitivity 66.7%, 81%, specificity 71.4%, 61.9% and overall accuracy 69% (p=0.014) and 71.4% (p=0.002). Statistically significant variation was observed between groups under study concerning age, creatinine, urea and serum IL-6 (significantly greater in hypertensive nephropathy stage III and IV subgroup). Conclusions: Omentin-1 concentrations decreased significantly with increasing body weight, as well as with HTN; mainly hypertensive nephropathy and higher stages of HTN. Furthermore, IL-6 increased significantly in obese, hypertensive and hypertensive nephropathy patients.

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Section: Discussionmentioning

confidence: 99%

Study of Serum Omentin-1 and IL-6 in Patients with Obesity, Hypertension and Hypertensive Nephropathy

2024

The Egyptian Journal of Hospital Medicine

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“…Compared to control group, prediabetic and T2DM patients with HT may have lower IL-10 levels, indicating inflammation 99 . T2DM and prediabetic patients with HT may have higher IL-6 levels than control group, indicating elevated inflammation in advanced disease stages 100 . Prediabetic and T2DM HT patients have been shown to have lower GSH/GSSG ratios, indicating increased oxidative stress 65 .…”

Section: Influence Of Medication On Biomarker Levelsmentioning

confidence: 99%

Comparative Analysis of Biomarkers in Type 2 Diabetes Patients with and without Comorbidities: Insights into the Role of Hypertension and Cardiovascular Disease

Savvopoulos,

Hatzikirou,

Jelinek

2024

Preprint

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Background: Type 2 diabetes mellitus (T2DM) are 90% of diabetes cases, and its prevalence and incidence, including comorbidities, are rising worldwide. Clinically, diabetes and associated comorbidities are identified by biochemical and physical characteristics including glycaemia, glycated hemoglobin (HbA1c), and tests for cardiovascular, eye and kidney disease. Objectives: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. Thus, identifying high-risk individuals can delay or prevent diabetes and its complications. Design: In patients with or without hypertension and cardiovascular disease, as part of progression from no diabetes to T2DM, this research studied the changes in biomarkers between control and prediabetes, prediabetes to T2DM, and control to T2DM, and classified patients based on first-attendance data. Control patients and patients with hypertension, cardiovascular, and with both hypertension and cardiovascular diseases are 156, 148, 61, and 216, respectively. Methods: Linear discriminant analysis is used for classification method and feature importance, This study examined the relationship between Humanin and mitochondrial protein (MOTSc), mitochondrial peptides associated with oxidative stress, diabetes progression, and associated complications. Results: MOTSc, reduced glutathione and glutathione disulfide ratio (GSH/GSSG), interleukin-1beta (IL-1beta), and 8-isoprostane were significant (p<0.05) for the transition from prediabetes to T2DM, highlighting the importance of mitochondrial involvement. Complement component 5a (C5a) is a biomarker associated with disease progression and comorbidities, with GSH/GSSG, monocyte chemoattractant protein-1 (MCP-1), and 8-isoprostane being the most important biomarkers. Conclusions: Comorbidities affect the hypothesized biomarkers as diabetes progresses. Mitochondrial oxidative stress indicators, coagulation, and inflammatory markers help assess diabetes disease development and provide appropriate medications. Future studies will examine longitudinal biomarker evolution.

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Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease

Savvopoulos,

Hatzikirou,

Jelinek

2024

Biomark�Insights

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Background: Type 2 diabetes mellitus (T2DM) are 90% of diabetes cases, and its prevalence and incidence, including comorbidities, are rising worldwide. Clinically, diabetes and associated comorbidities are identified by biochemical and physical characteristics including glycemia, glycated hemoglobin (HbA1c), and tests for cardiovascular, eye and kidney disease. Objectives: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. Thus, identifying high-risk individuals can delay or prevent diabetes and its complications. Design: In patients with or without hypertension and cardiovascular disease, as part of progression from no diabetes to T2DM, this research studied the changes in biomarkers between control and prediabetes, prediabetes to T2DM, and control to T2DM, and classified patients based on first-attendance data. Control patients and patients with hypertension, cardiovascular, and with both hypertension and cardiovascular diseases are 156, 148, 61, and 216, respectively. Methods: Linear discriminant analysis is used for classification method and feature importance, This study examined the relationship between Humanin and mitochondrial protein (MOTSc), mitochondrial peptides associated with oxidative stress, diabetes progression, and associated complications. Results: MOTSc, reduced glutathione and glutathione disulfide ratio (GSH/GSSG), interleukin-1β (IL-1β), and 8-isoprostane were significant ( P < .05) for the transition from prediabetes to t2dm, highlighting importance of mitochondrial involvement. complement component 5a (c5a) is a biomarker associated with disease progression and comorbidities, gsh gssg, monocyte chemoattractant protein-1 (mcp-1), 8-isoprostane being most important biomarkers. Conclusions: Comorbidities affect the hypothesized biomarkers as diabetes progresses. Mitochondrial oxidative stress indicators, coagulation, and inflammatory markers help assess diabetes disease development and provide appropriate medications. Future studies will examine longitudinal biomarker evolution.

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Study of the Relation between Il-6, Insulin Resistance, and Blood Pressure in Essential Hypertensive Patients

Cited by 4 publications

References 0 publications

Study of Serum Omentin-1 and IL-6 in Patients with Obesity, Hypertension and Hypertensive Nephropathy

Study of Serum Omentin-1 and IL-6 in Patients with Obesity, Hypertension and Hypertensive Nephropathy

Comparative Analysis of Biomarkers in Type 2 Diabetes Patients with and without Comorbidities: Insights into the Role of Hypertension and Cardiovascular Disease

Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease

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