Study of the reaction of ninhydrin with tyrosine in gemini micellar media

Kumar, Dileep; Rub, Malik Abdul

doi:10.1039/c9ra03557e

Cited by 48 publications

(15 citation statements)

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“…The study deals with the synthesis and characterization of gemini surfactants and their influence on the kinetic behavior of ninhydrin with zinc-glycylleucine. The reason for choosing this particular study is the mechanism of ninhydrin with amino acids reaction in water, conventional surfactants (CTAB, cetylpyridinium bromide, CPB) and the various solvent medium is well recognized [24][25][26][27][28][29][30]59 . Under the identical reaction condition, it was found that the study was catalyzed and accelerated quite enough in gemini surfactants (below their cmc value) than aqueous medium 73 .…”

Section: Discussionmentioning

confidence: 99%

“…Ninhydrin reactions are one of the most fundamental and biochemical studies. Ninhydrin, a chemical reagent, is used enormously for detection of amine functional group wherein it reacts with an amino group and generates diketohydrindylidene-diketohydridamine (DYDA) [22][23][24][25][26][27][28][29][30] . The color of the product formed between the reaction of ninhydrin and amino acids disappears at room temperature, several efforts were performed towards the stability of products that include the formation of the metal complex with amino acids, change of solvent, presence of conventional monomeric surfactant 28,[31][32][33] .…”

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confidence: 99%

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Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles

Azum

Kumar

2020

Sci Rep

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the three Gemini (m-s-m; m (head group) = 16 and s (spacer) = 4, 5, 6) surfactants have been synthesized and their impact on reaction of zinc(ii)-glycylleucine complex ([Zn(ii)-Gly-Leu] +) and ninhydrin were studied at temperature (343 K) and pH (5.0) using spectroscopic method. Influence of several factors, viz., [Zn(II)-Gly-Leu] + , [ninhydrin], temperature and pH were also carried out on title reaction in geminis. Rates of reaction are the first-order path in concentration of [Zn(II)-Gly-Leu] + complex and fractional order path in concentration of ninhydrin. The catalysis of gemini 16-s-16 surfactant micelles was investigated below and above their critical micelle concentration (cmc) value and detailed elaboration were provided in the text. In the present case, rate constants, k ψ , increased on increasing geminis ([gemini] are below their cmc, region I) and stayed nearly constant (region II). The shape of (region I and II) surfactants ([gemini] = 0 to 400 × 10 −5 mol dm −3) are similar to a cetyltrimethylammonium bromide, CTAB (single hydrophilic head group and hydrophobic part). Later, a sharp increment in rate was observed with higher [gemini] (region III, (Fig. 5). The study was catalyzed and accelerated quite enough by geminis (at concentrations below their cmc) compared to aqueous. An appropriate mechanism has been proposed for accounting for the distribution of reactants between aqueous and micellar pseudo phases. Resulting kinetic data were used to determine the binding constants of micelle-substrate (K B) and micelle-ninhydrin (K nin).

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles

Azum

Kumar

2020

Sci Rep

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“…By using these results, different activation parameters were calculated by linear least-squares regression procedure. The mechanism of amino acids with ninhydrin has received great attention of researchers/investigators due to the use in different fields [47][48][49][50][51]. The proposed mechanism for the current study of ninhydrin and histidine is demonstrated in scheme 1.…”

Section: Effect Of Several Parameters On K ψmentioning

confidence: 99%

Catalytic influence of 16- s -16 gemini surfactants on the rate constant of histidine and ninhydrin

Kumar

Rub

2020

R. Soc. open sci.

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The present paper reports the catalytic influence of 16-s-16 (spacer (s) = 4, 5, 6) gemini surfactants on the rate constant of histidine and ninhydrin at 343 K and pH 5.0 using the spectrophotometric technique. The effect of varying amounts of geminis was made on the rate constant of histidine and ninhydrin keeping other constituents constant. Characteristics of the rate constant (k ψ ) versus [gemini] depict the effect of surfactants on the rate constant. A systematic explanation about the effect of surfactants is revealed and discussed in the text. The influence of different parameters that includes [reactants], temperature and pH has also been performed on the study. In order to determine the critical micelle concentration (cmc) of pure surfactants and their solution mixtures, conductivity measurement was employed. By using the Eyring equation, activation parameters at different temperatures have been obtained. The resultant data of k ψ versus [gemini] plot were rationalized with the pseudo-phase model of micelles.

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“…In an aqueous medium, a surfactant can form aggregates at a certain concentration due to a delicate balance of hydrophilic interactions and hydrophobic interactions. 1 This surfactant aggregate is known as a micelle, and the concentration at which a surfactant micelle formed is known as cmc. [2][3][4] This micellar aggregation of an amphiphilic substance can augment the solubility of weakly soluble organic compounds by altering their microenvironment properties e.g.…”

Section: Introductionmentioning

confidence: 99%

Effects of temperature and polyols on the ciprofloxacin hydrochloride-mediated micellization of sodium dodecyl sulfate

et al. 2020

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Study of the reaction of ninhydrin with tyrosine in gemini micellar media

Abstract: The importance of the study increased due to the use of a very small quantity of gemini surfactant required to perform the reaction.

Cited by 48 publications

References 59 publications

Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles

Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles

Catalytic influence of 16- s -16 gemini surfactants on the rate constant of histidine and ninhydrin

Effects of temperature and polyols on the ciprofloxacin hydrochloride-mediated micellization of sodium dodecyl sulfate

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