Study of the reaction of complexation of penicillin V with cobalt(II) in methanolic medium

Martinez, Juan Hernandez; Martínez, Pedro García; Gutiérrez, Pilar; Martinez, Ma Isabel

doi:10.1016/0039-9140(92)80073-m

Cited by 9 publications

(1 citation statement)

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“…The inference drawn from these findings posited that these complexes exhibited chelation behavior due to the coordination of the ligand (the Bzpanion) through the O atom of the carboxylate group and the N atom of the -lactam group. Subsequent spectrophotometric investigations delved into the interaction of phenoxymethylpenicillin (Fmp)with Cu(II) and Co(II) [4,5], revealing the formation of complexes denoted as ML and ML2. The coordination of Fmp-through the carboxylate group and the -lactam N atom was proposed.…”

Section: Introductionmentioning

confidence: 99%

Thermal, X-ray spectroscopy, morphological, density functional theory and molecular modeling studies on yttrium(III), germanium(IV), tungsten(VI), and silicon penicillinate antibiotic complexes

A. El-Habeeb,

Shakya,

Y. El-Sayed

et al. 2024

Bull. Chem. Soc. Eth.

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This manuscript elucidates the thermal stability analysis of four distinct penicillinate complexes, comprising yttrium(III), germanium(IV), tungsten(VI), and silicon, over a temperature ranging from 25 to 800°C. Thermal data revealed the high thermal stability nature of the decomposition steps. According to the spectroscopic measurements, the chemical formula of penicillinate complexes were [Y(Pin)2].Cl.6H2O complex (1), [Ge(Pin)2].2Cl.2H2O complex (2), [W(Pin)2].4Cl complex (3), and [Si(Pin)2].2Cl.2H2O complex (4). The powder XRD pattern revealed crystalline to polycrystalline natures. The synthesized penicillinate complexes were subjected to theoretical calculations utilizing density functional theory (DFT) calculations, employing the lanL2DZ/6-311G++ level of theory. The optimized geometry of each penicillinate complex was discerned, and a comprehensive evaluation of various properties, including the HOMO→LUMO electronic energy gap, molecular electrostatic potential map, and additional physical parameters, was conducted and validated against experimental findings. Molecular docking tool was used to explore the anticancer activity of the synthesized penicillinate complexes in comparison with penicillin potassium drug (Pin). For the computational investigation, two kinases — CSF1R (PDB ID: 7MFC) and MEK2 (PDB ID: 1S9I) associated with breast cancer progression and estrogen-dependent breast cancer were utilized. This comprehensive analysis provides a deeper understanding of the synthesized penicillinate complexes and their potential applications. KEY WORDS: Penicillinate complexes, TGA-DrTGA, TEM, XRD, DFT/TD-DFT, Molecular docking Bull. Chem. Soc. Ethiop. 2024, 38(4), 973-988. DOI: https://dx.doi.org/10.4314/bcse.v38i4.13

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Section: Introductionmentioning

confidence: 99%

Thermal, X-ray spectroscopy, morphological, density functional theory and molecular modeling studies on yttrium(III), germanium(IV), tungsten(VI), and silicon penicillinate antibiotic complexes

A. El-Habeeb,

Shakya,

Y. El-Sayed

et al. 2024

Bull. Chem. Soc. Eth.

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Spectrophotometric determination of 6-aminopenicillanic acid using bromophenol blue and bromothymol blue

Amin

Issa

1995

Mikrochim Acta

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Abstract. Two simple, selective and sensitive spectrophotometric methods are described for the determination of 6-aminopenicillanic acid (6-APA). The methods are based on the reaction of 6-APA with either bromophenol blue (BPB) or bromothymol blue (BTB), to give orange-red and green species, respectively. The coloured products are quantified spectrophotometrically at 625 and 616nm for BPB and BTB, respectively. The optimization of the different experimental conditions is described. No interferences from different fi-lactams and common degradation products were observed in the determination of 6-APA using BTB, while flucloxacillin, dicloxacillin, adrenaline, vitamin C, urea and common degradation products in any percentage interfere on using BPB only. The BTB method was better than the BPB method, because of its wider range of determination (0.4-20ggm1-1vs. 0.4-7.2 gg m1-1 on using BPB), higher molar absorptivity and Sandell sensitivity (3.27 x 1031tool -1 cm -1 and 0.099 tag cm-2 vs. 2.82 x 1031mol -~ cm -1 and 0.1151ag cm-2), greater stability (3 and 10 days on using BTB and BPB, respectively) and better selectivity. The results were compared with those given by the Official United States Pharmacopeial XXI method.Key words: 6-aminopenicillanic acid, bromophenol blue, bromothymol blue, spectrophotometry.Bromocresol purple is known to yield charge transfer complexes which are applied for the determination of heparin [1] and erythromycin [-2]. Bromocresol green is also known to yield a charge transfer complex, which is applied in the determination of phenytoin sodium [3].The importance of penicillins as broad spectrum antibiotics is well known. 6-aminopenicillanic acid [551-16-6] is one of the penicillin group of antibiotic

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Metal complexes of penicillins and cephalosporins (Review)

Алексеев

2012

Pharm Chem J

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Study of the reaction of complexation of penicillin V with cobalt(II) in methanolic medium

Cited by 9 publications

References 4 publications

Thermal, X-ray spectroscopy, morphological, density functional theory and molecular modeling studies on yttrium(III), germanium(IV), tungsten(VI), and silicon penicillinate antibiotic complexes

Thermal, X-ray spectroscopy, morphological, density functional theory and molecular modeling studies on yttrium(III), germanium(IV), tungsten(VI), and silicon penicillinate antibiotic complexes

Spectrophotometric determination of 6-aminopenicillanic acid using bromophenol blue and bromothymol blue

Metal complexes of penicillins and cephalosporins (Review)

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