Study of the Preparation and Properties of Chrysin Binary Functional Monomer Molecularly Imprinted Polymers

Abstract

Chrysin is a natural bioactive molecule with various groups, and it has been a challenge to separate and enrich chrysin from natural products. Molecularly imprinted polymers have been widely used in the extraction of natural products, but the number and type of functional monomers limits the separation effect. The synergistic action of multiple functional monomers can improve the separation effect. In this paper, molecularly imprinted polymers (Bi-MIPs) were prepared using methacrylic acid and acrylamide as binary functional monomers for the separation and enrichment of chrysin. The Bi-MIPs were characterized using thermogravimetric analyzer (TGA), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The performances of Bi-MIPs were assessed, which included adsorption isotherms, selective recognition and adsorption kinetics. The experimental results show that Bi-MIPs are shaped as a uniform sphere with an abundant pocket structure on its surface. The adsorption of chrysin on the Bi-MIPs followed a pseudo-second-order and adapted Langmuir–Freundlich isotherm models. The adsorption performance of the Bi-MIPs was determined at different temperatures, and the Bi-MIPs showed excellent adsorption performance at 30 °C. The initial decomposition temperature of the Bi-MIPs was 220 °C. After five times of adsorption and desorption, the adsorption performance of the Bi-MIPs decreased by only 7%. In contrast with single functional monomer molecularly imprinted polymers (Si-MIPs), the Bi-MIPs showed excellent specificity, with an imprinting factor of 1.54. The Bi-MIPs are promising materials in the separation and enrichment of chrysin for their high adsorption capacity, low cost and being environmentally friendly.

Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism

“…Firstly, both MMIPs and MNIPs may exhibit a certain degree of surface roughness or nanoscale irregularities. These irregularities can create additional binding sites for dexamethasone and hydrocortisone molecules, thereby promoting multilayer adsorption [29]. Additionally, molecularly imprinted polymers (MIPs) are synthetic multifunctional materials characterized by a high affinity and specificity for target molecules [30][31][32], enabling the adsorption of multiple layers of these molecules onto the polymer's surface.…”

Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective

“…Recently, Chrzanowska et al [ 39 ] reported that the binding selectivity of the MIPs synthesized using 2-(dimethylamino) ethyl methacrylate (DEM) as monomers was 5 folds higher than that synthesized using methacrylic acid (MAA) as monomers. Li et al [ 40 ] reported that fabrication of binary MIPs (Bi-MIPs) using MAA and AM as binary functional monomers was also an efficient way to enhance the adsorption performance of the MIPs (the imprinting factor (IF) of the Bi-MIPs was 1.54 times to the ordinary MIPs).…”