Study of the Possibility of Creating a Drug Coating for Biliary Stents Based on the Copolymer “Polylactic Acid/Polycaprolactone” Modified with Carbon Nanotubes and Doxorubicin

Abstract

Mechanical jaundice usually refers to a symptom complex that occurs when the outflow of bile through the bile ducts of the liver is disturbed. This disease is an indication for stenting. Unfortunately, over time, physicians have noted a number of disadvantages of endobiliary stenting, the main of which has been the manifestation of restenosis. Also, within the first few hours of completing the stenting procedure, there may be a risk of serious complications such as thrombosis and restenosis. To reduce the risks of such complications as well as to improve the future results of the operation, stents with special drug coatings have started to be used. To ensure local transportation, quality application of the drug substance on the surface of the biliary stent, and prolonged drug release, it is necessary to create a polymeric carrier complex. This article considers the possibility of creating an ultrathin drug coating for biliary stents. The article also presents theoretical calculations of the interaction of complexes of carrier polymers and the copolymer “polylactic acid/polycaprolactone” modified by carbon nanotubes. This coating is proposed to improve biocompatibility during endobiliary stenting.