Study of the Photophysical Behavior and the Photostability of an Azlactone Derivative Encapsulated in Cyclodextrin

Abstract

The azlactones are well known compounds and are important intermediates in the synthesis of chiral heterocyclic amino acids. Even with high intensities of fluorescence emission, very few studies were found in literature about their photophysical and photochemical properties. Due to the low solubility in aqueous solution, we carried out the photochemical and photophysical study of these compounds in aqueous and hydroalcoholic solution in the presence of cyclodextrins since, according to literature data, the encapsulation can enhance the stability of the encapsulated molecule as well as modify its photophysical properties. The results showed increase of absorption intensity of azlactone after encapsulation in the β-cyclodextrin (b-CD) cavity in aqueous-alcoholic medium, however it is observed the decrease in the photostability azlactone derivative in aqueous-alcoholic medium.