Study of the peculiarities of combined opisthorchosis and helicobacteriosis

Abstract

The purpose of the research is identifying patients with helicobacteriosis and opisthorchosis, and determining regular features of the course of combined diseases.Materials and methods. The study involved 50 patients in the Gastroenterology Department with helicobacteriosis diagnosed. Helicobacter pylori was confirmed by the HP test during fibrogastroduodenoscopy. Opisthorchis felineus was detected in patients using the study of feces by the Kato technique and enrichment method. The patients were divided into 2 groups of 25 people each. The first group only consisted of patients with H. pylori. The second group consisted of patients in whom H. pуlori and O. felineus were identified. Initially, the levels of aminotransferases and bilirubin were assessed using a biochemical blood test on a MIURA 200 apparatus. The manifestation of such clinical symptoms as abdominal pain was assessed using a visual analogue scale (VAS). Further, the eradication of H. pylori during therapy was assessed based on the Maastricht V recommendations for 14 days, including the use of three drugs: omeprazole at a dose of 20 mg 2 times a day, clarithromycin – 500 mg 2 times a day, amoxicillin – 1000 mg 2 times a day, and the effectivity of treatment of patients of the second group with opisthorchosis with the use of praziquantel at a dose of 60 mg/kg of body weight during the day three times every 4 hours.Results and discussion. In the second group of patients with combined pathology, pain intensity was estimated at 4–5 scores in 20 people (80%), and at 2–3 scores in 25 people (100%) in the first group. The severity of nausea was also higher in 100% of patients in the second group. Values for AST and ALT in blood were higher in patients of the second group – by an average of 50–100% in 18 people (72%); increase in the level of bilirubin by 15% in 23 people (92%). Combined pathology (opisthorchosis and helicobacteriosis) is accompanied by more pronounced clinical symptoms (abdominal pain and nausea). In patients with opisthorchosis and H. pуlori, aminotransferases increased up to three reference values and bilirubin increased by 15% were noted. For helicobacteriosis and opisthorchosis, longer treatment was required. The presence of H. pylori at the same time with opisthorchosis did not affect the efficacy of antiparasitic therapy.