“…Whether a spontaneous hybrid or a product of human breeding, all of the Cabernet Sauvignon grown around the world is thought to have resulted from this single hybridization event. Just as the parents of Cabernet Sauvignon have been identified, the genetic origin of many other important wine grape cultivars is known, and they often originate from the direct crossing of common, distantly-related cultivars (Strefeler et al, 1992 ; Ohmi et al, 1993 ; Qu et al, 1996 ; Bowers and Meredith, 1997 ; Sefc et al, 1998 ; Lopes et al, 1999 ; Crespan and Milani, 2001 ; Vouillamoz et al, 2003 , 2004 ; Di Gaspero et al, 2005 ; Vouillamoz and Grando, 2006 ; Lacombe et al, 2007 , 2013 ; Tapia et al, 2007 ; Boursiquot et al, 2009 ; Ibáñez et al, 2009 ; Cipriani et al, 2010 ; Myles et al, 2011 ; García-Muñoz et al, 2012 ). Due to this intraspecific hybridization process, levels of heterozygosity in grape cultivars can easily exceed 11% (Jaillon et al, 2007 ).…”