Study of the occurrence and ecosystem danger of selected endocrine disruptors in the urban water cycle of the city of Bogotá, Colombia

Bedoya-Ríos, Diego F.; Lara-Borrero, Jaime Andrés; Duque-Pardo, Verónica; Madera-Parra, Carlos A.; Jimenez, Eliana M.; Toro, A. F.

doi:10.1080/10934529.2017.1401372

Cited by 41 publications

(15 citation statements)

References 55 publications

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“…Environmental risk assessment for EDCs is a crucial issue in toxicological, biological and epidemiological disciplines (Bedoya-Ríos et al, 2017). EDCs are exogenous pollutants that enter the environment through human activities, and they have the potential to bioaccumulate in humans and wildlife (Gorelick et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

Huang

Lin

et al. 2020

Ecotoxicology and Environmental Safety

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Herein, eight common endocrine disrupting chemicals (EDCs) were exposed to zebrafish (Danio rerio) to investigate the relationship between different EDCs and their activated estrogen receptors. Under acute exposure, we identified five major malformation types whose incidence and deformity modes differed among EDCs. Luciferase analysis divided the EDC receptors into four categories: (i) triclosan (TCS), 17ß-estradiol (E2) and estriol (E3) mainly activated GPER expression; (ii) bisphenol A (BPA), p-(tert-octyl) phenol (POP), 17α-ethynylestradiol (EE2), E2 and E3 activated ERβ expression; (iii) E2 and E3 acted on both GPER and ERβ; and (iv) estrone (E1) and 9,9-bis(4-hydroxyphenyl)fluorene (BHPF) had little effect on the two receptors. In vivo immunofluorescence experiments on 96-hpf larvae provided evidence that TCS and POP acted on GPER and ERβ, respectively, while E2 acted on the two receptors simultaneously. Luciferase activities in the promoter regions of gper (À 986 to À 488) and erβ (À 1998 to À 1496) were higher than those in other regions, identifying these key regions as targets for transcription activity. TCS promoted GPER expression by acting on the JUND transcription factor, while POP promoted ERβ expression by activating the Foxl1 transcription factor. In contrast, E2 mainly regulated transcription of GPER and ERβ by Arid3a. These findings provide compelling evidence that different EDCs possess varying estrogen receptors, leading to differential regulatory pathways and abnormality symptoms. These results offer an experimental strategy and fundamental information to assess the molecular mechanisms of EDC-induced estrogen effects.

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Section: Discussionmentioning

confidence: 99%

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

Huang

Lin

et al. 2020

Ecotoxicology and Environmental Safety

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“…United States (Li, 2018) First-Tier Risk Quotient (RQ) Approach Aquatic Ecosystems Bangladesh (Sumon et al, 2018) Toxicity Units Aquatic Ecosystems Ghana (Affum et al, 2018) ChimERA fate Shallow Aquatic Ecosystems Italy (Morselli et al, 2018) Although there have been studies on the presence and monitoring of organophosphorus pesticides in aquatic ecosystems in latitudes close to the tropics (Carro et al, 2012;Singare, 2016;Huang, Tornero-Velez and Barzyk, 2017;Bedoya-Ríos et al, 2018;Moncaleano-Niño et al, 2018), it is necessary to do more research about the dynamic, and impact of the OPPs, because in equatorial regions like Colombia, due to its distinctive climatological conditions processes such as occurrence, distribution and fate of organophosphorus compounds as Chlorpyrifos and its degradation products are still poorly known (61).…”

Section: Soilmentioning

confidence: 99%

Environmental Risk assessment of Chlorpyrifos and TCP in Aquatic Ecosystems

Arguello¹,

Valderrama

Villa

et al. 2020

reveia

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Chlorpyrifos is a commonly used pesticide that belong to the organophosphorus pesticides (OPPs) group. Chlorpyrifos is widely used in residential environments and agriculture for pest control. As many OPPs, Chlorpyrifos degrades faster to more complex and toxic compounds under natural conditions, thus diverse effects of these compounds over aquatic species are unknown. Due to the risk that pesticides as Chlorpyrifos, which mainly breaks down to 3,5,6- trichloro-2-pyridinol (TCP) on the ecosystems, there is an increasing need to intensify the environmental monitoring and ecotoxicological risk assessment for both substances. Risk assessment provides a systematic approach for characterizing the nature and magnitude of the risks associated with environmental health hazards. However, in countries like Colombia, where the use of Chlorpyrifos is widespread, the number of investigations on the dynamics and risk involved in the presence of this class of substances in water bodies is limited.

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“…The main source of contamination in the Magdalena and Cauca basins is wastewater from the main cities Bogotá, Medellín, Cali, and Barranquilla (Galvis and Mojica 2007;Tejeda-Benitez et al 2016). In these cities, some research has been carried out on the content of PPCPs in the waters, nding that the greatest contribution of pharmaceutical products is non-steroidal anti-in ammatory drugs, anticonvulsants, and antibiotics (Gracia-Lor et al 2012;Hernández et al 2015;Aristizabal-Ciro et al 2017;Bedoya-Ríos et al 2018;Arias 2019;Pemberthy et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of mitochondrial membrane potential and DNA integrity in Catfish Pseudoplatystoma magdaleniatum, when exposed for prolonged times to different concentrations of ibuprofen.

Ríos¹,

Peñuela²

2021

Preprint

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There are few studies to date that determine the effects of ibuprofen on mitochondrial membrane potential (ΔΨM) and DNA integrity in neotropical fish. The objective of this study is to determine if four months’ exposure to ibuprofen in different concentrations (25 and 50 µg/L) produces effects on ΔΨM and alters the integrity of DNA in striped catfish Pseudoplatystoma magdaleniatum. For this study, the fish were placed in tanks with water at constant concentrations of 0 (control), 25, and 50 µg/L of ibuprofen for four months. Subsequently, blood samples were taken for analysis of ΔΨM and DNA integrity, using a flow cytometer LSRFortessa BD Biosciences. After four months of exposure to ibuprofen at different concentrations, the results showed no increase in Low ΔΨM, indicating that there are no alterations in the mitochondrial membrane potential. On the other hand, the percentages of DNA damage were below 0.39, which indicates that there were no alterations in DNA integrity. It is possible that under the conditions in which this study was conducted (ibuprofen levels, exposure time), they are not sufficient to demonstrate the effects caused by this drug. Higher ibuprofen levels and/or longer exposures may be required to determine alteration in ΔΨM and DNA integrity. Flow cytometric analysis for these types of samples is a fast, specific, and reliable technique, compared to traditional methods.

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Study of the occurrence and ecosystem danger of selected endocrine disruptors in the urban water cycle of the city of Bogotá, Colombia

Cited by 41 publications

References 55 publications

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

Environmental Risk assessment of Chlorpyrifos and TCP in Aquatic Ecosystems

Evaluation of mitochondrial membrane potential and DNA integrity in Catfish Pseudoplatystoma magdaleniatum, when exposed for prolonged times to different concentrations of ibuprofen.

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