Study of the Molecular Mechanisms of the Therapeutic Properties of Extracellular Vesicles

Silachev, Denis N.

doi:10.3390/ijms24087093

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…EV-mediated communication between kingdoms highlights the complex connections within biological systems and opens up possibilities for the development of new therapeutic strategies utilizing their unique biological properties. EVs derived from bacteria, fungi or plants have shown an effect on physiological processes in human cells and tissues and can also be considered potential nanocontainers for drug delivery [ 122 ].…”

Section: Sources Of Evs and Methods For Their Isolationmentioning

confidence: 99%

A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic

Goryunov,

Ivanov,

Kulikov

et al. 2024

IJMS

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Neonatal disorders, particularly those resulting from prematurity, pose a major challenge in health care and have a significant impact on infant mortality and long-term child health. The limitations of current therapeutic strategies emphasize the need for innovative treatments. New cell-free technologies utilizing extracellular vesicles (EVs) offer a compelling opportunity for neonatal therapy by harnessing the inherent regenerative capabilities of EVs. These nanoscale particles, secreted by a variety of organisms including animals, bacteria, fungi and plants, contain a repertoire of bioactive molecules with therapeutic potential. This review aims to provide a comprehensive assessment of the therapeutic effects of EVs and mechanistic insights into EVs from stem cells, biological fluids and non-animal sources, with a focus on common neonatal conditions such as hypoxic–ischemic encephalopathy, respiratory distress syndrome, bronchopulmonary dysplasia and necrotizing enterocolitis. This review summarizes evidence for the therapeutic potential of EVs, analyzes evidence of their mechanisms of action and discusses the challenges associated with the implementation of EV-based therapies in neonatal clinical practice.

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Section: Sources Of Evs and Methods For Their Isolationmentioning

confidence: 99%

A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic

Goryunov,

Ivanov,

Kulikov

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Study of the Molecular Mechanisms of the Therapeutic Properties of Extracellular Vesicles

Abstract: Extracellular vesicles (EVs) are small biological structures that are released by cells and have important roles in intercellular communication [...]

Cited by 1 publication

References 27 publications

A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic

A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic

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