Study of the mechanisms of formation of nanoparticles and nanocapsules of polyisobutyl-2-cyanoacrylate

Gallardo, Montserrat; Couarraze, G.; Denizot, B.; Treupel, L.; Couvreur, Patrick; Puisieux, F.

doi:10.1016/0378-5173(93)90075-q

Cited by 73 publications

(50 citation statements)

References 16 publications

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“…Nanocapsule dispersions may be contaminated with nanospheres. To reduce the contamination, it can be recommended to optimize the ethanol/oil ratio of the organic phase and to acidify the organic phase in order to inhibit the start of the anionic polymerization of the monomer (21,125,126). Improvements can also be obtained by replacing ethanol by aprotic solvents such as acetone and acetonitrile which are not able to initiate the polymerization reaction (127).…”

Section: Polymerization Of Alkylcyanoacrylatesmentioning

confidence: 98%

“…The polymerization occurs at the interface of the fine oil droplets which forms when the organic phase including a water miscible solvent, the oil and the monomer is mixed with the aqueous phase containing a surfactant like pluronic F68. In this method, critical factors are the phase separation of the oil droplets occurring during the diffusion of the water miscible organic solvent in the aqueous phase and the simultaneous precipitation of the nascent polymer at oil/water interface (126). Nanocapsule dispersions may be contaminated with nanospheres.…”

Section: Polymerization Of Alkylcyanoacrylatesmentioning

confidence: 99%

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Methods for the Preparation and Manufacture of Polymeric Nanoparticles

2008

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This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules. The first part summarizes the basic principle of each method of nanoparticle preparation. It presents the most recent innovations and progresses obtained over the last decade and which were not included in previous reviews on the subject. Strategies for the obtaining of nanoparticles with controlled in vivo fate are described in the second part of the review. A paragraph summarizing scaling up of nanoparticle production and presenting corresponding pilot set-up is considered in the third part of the review. Treatments of nanoparticles, applied after the synthesis, are described in the next part including purification, sterilization, lyophilization and concentration. Finally, methods to obtain labelled nanoparticles for in vitro and in vivo investigations are described in the last part of this review.

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Section: Polymerization Of Alkylcyanoacrylatesmentioning

confidence: 98%

Section: Polymerization Of Alkylcyanoacrylatesmentioning

confidence: 99%

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

2008

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“…Taking these preliminary remarks into account, it seems possible that particle formation, and therefore the size of the particles, is governed by a phenomenon of fragmentation of the acidic flow in the basic surrounding media, comparable to a process of microemulsification or the formation of polymeric organic particles (19). Following this theory, to get a 5-nm particle, a cubic aqueous volume of approximately 86 nm 3 is necessary when an iron concentration of 38.8 mM is assumed.…”

Section: Figmentioning

confidence: 98%

Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study

Babes¹,

Denizot²,

Tanguy³

et al. 1999

Journal of Colloid and Interface Science

529

274

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“…The particles are completely covered with a surfactant which possesses an interfacial tension, close to zero at the oil/water interface [37].…”

Section: Microemulsion Polymerizationmentioning

confidence: 99%

Nanoparticles: A Promising Drug Delivery Approach

Kadian¹

2018

Asian J Pharm Clin Res

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Nanoparticles are particles having a size range of 1 and 100 nanometers, defined as a small object behaving as a complete unit with respect to the drug transport and therapeutic properties. They have several advantages such as improvement in the intracellular infiltration, enhanced hydrophobic solubility, and circulation time of the drug. They reduce non-specific uptake and side effects of the conventional drug delivery systems. Nanoparticles offer more effective and convenient routes of administration (oral, pulmonary, parenteral, and transdermal) and used for drug delivery for treatment of cancer, diabetes, pain, asthma, allergy, infections, and so on. They allow targeted delivery and controlled release of the drug. Further research on their mechanism of action to meet better stability of nanoparticles in the biological system could be done.

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Study of the mechanisms of formation of nanoparticles and nanocapsules of polyisobutyl-2-cyanoacrylate

Cited by 73 publications

References 16 publications

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study

Nanoparticles: A Promising Drug Delivery Approach

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