Study of the incremental cost and clinical burden of hip fractures in postmenopausal women in the United Kingdom

Gutiérrez, Lia; Roskell, Neil; Castellsagué, Jordi; Beard, Stephen; Rycroft, Catherine; Abeysinghe, Shaun; Shannon, Paul; Robbins, Sean; Gitlin, Matthew

doi:10.3111/13696998.2010.547967

Cited by 31 publications

(36 citation statements)

References 17 publications

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“…One in two women and one in five men aged fifty and over in the UK will suffer a fracture in their lifetime [1]. Osteoporotic fractures commonly occur at the hip, spine, and wrist and of these hip fractures have the highest short-term mortality, morbidity and associated socioeconomic impact [2][3][4]. Regular exercise is widely recommended as the most effective nonpharmacological method for improving and maintaining BMD [5] and can also reduce the risk of falling.…”

Section: Introductionmentioning

confidence: 99%

High impact exercise increased femoral neck bone mineral density in older men: A randomised unilateral intervention

Allison

Folland

Rennie

et al. 2013

Bone

121

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Section: Introductionmentioning

confidence: 99%

High impact exercise increased femoral neck bone mineral density in older men: A randomised unilateral intervention

Allison

Folland

Rennie

et al. 2013

Bone

121

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“…137,149 When the results of these previous studies were inflated to 2012-13 prices, we found considerable variability in the reported 1-year costs after hip fracture, with estimates between £6176 137 and £20,470. 137,149 However, these studies focused solely on women with hip fractures. Hence our study contributes significantly to the evidence base regarding hip fractures by identifying and following large populations of hip fracture patients in primary and hospital care up to 2 years before and after the index event.…”

mentioning

confidence: 98%

“…micro costing or valuing HRGs). These help to explain the significant variability in the reported costs; for example, the reported costs for acute inpatient admission with hip fracture varied from £4202 to £16,452 (2012-13 prices).Focusing on the four more recent studies, Gutiérrez et al 137 reported costs based on 2427 women aged > 50 years identified in a primary care research database. The time horizon of the analysis was 12 months post hip fracture.…”

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confidence: 99%

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Models of care for the delivery of secondary fracture prevention after hip fracture: a health service cost, clinical outcomes and cost-effectiveness study within a region of England

Judge

Javaid

Leal

et al. 2016

Health Serv Deliv Res

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms VOLUME 4 ISSUE 28 SEPTEMBER 2016 ISSN 2050 DOI 10.3310/hsdr04280 HEALTH SERVICES AND DELIVERY RESEARCHModels of care for the delivery of secondary fracture prevention after hip fracture: a health service cost, clinical outcomes and cost-effectiveness study within a region of England Andrew Judge, M Kassim Javaid, José Leal, Samuel Hawley, Sarah Drew, Sally Sheard, Daniel Prieto-Alhambra, Rachael Gooberman-Hill, Janet Lippett, Andrew Farmer, Nigel Arden, Alastair Gray, Michael Goldacre, Antonella Delmestri and Cyrus Cooper Models of care for the delivery of secondary fracture prevention after hip fracture: a health service cost, clinical outcomes and cost-effectiveness study within a region of England Declared competing interests of authors: Daniel Prieto-Alhambra has received unrestricted research and educational grants from Amgen and Bioibérica S.A. Nigel Arden reports personal fees from Merck Sharp & Dohme (MSD), grants and personal fees from Roche, personal fees from Smith and Nephew, personal fees from Q-Med, personal fees from Nicox, personal fees from Flexion, personal fees from Bioibérica and personal fees from Servier. Cyrus Cooper has received consultancy fees, lecture fees and honoraria from Amgen, GlaxoSmithKline, Alliance for Better Bone Health, Eli Lilly, Pfizer, Novartis, MSD, Servier, Medtronic and Roche. M Kassim Javaid has in the last 5 years received honoraria for travel expenses, speaker fees and/or advisory committees from Lilly UK, Amgen, Servier, MSD, Medtronic, Internis, Consilient Health and Jarrow Formulas. He also serves on the Scientific Committee of the National Osteoporosis Society and International Osteoporosis Foundation. Andrew Judge has received consultancy fees, lecture fees and honoraria from Servier, UK Renal Registry, Oxford Craniofacial Unit, IDIAP Jordi Gol and Freshfields Bruckhaus Deringer, is a member of the Data Safety and Monitoring Board (which involved receipt of fees) from Anthera Pharmaceuticals, Inc., and received consortium research grants from Roche.Published September 2016 DOI: 10.3310/hsdr04280 This report should be referenced as follows:Judge A, Javaid MK, Leal J, Hawley S, Drew S, Sheard S, et al. Models of care for the delivery of secondary fracture prevention after hip fracture: a health service cost, clinical outcomes and cost-effectiveness study within a region of England. Health Serv Deliv Res 2016;4(28). Health Services and Delivery ResearchISSN 2050-4349 (Print) ISSN 2050-4357 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HS&DR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hsdr. Print-on-demand copies can be purchased from the repor...

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“…The Health Improvement Network (THIN) database has been used to characterize the risk of fracture associated with several chronic conditions and drug exposures in adults and children (19)(20)(21)(22)(23)(24)(25)(26). The objectives of this large population-based study were to determine whether urolithiasis is associated with a higher risk of incident fracture and to delineate age and sex effects.…”

Section: Introductionmentioning

confidence: 99%

Risk of Fracture in Urolithiasis

Denburg

Leonard

Haynes

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Studies have shown decreased bone mineral density in individuals with urolithiasis, but their burden of fracture remains unclear. This study sought to determine whether urolithiasis is associated with increased fracture risk across the lifespan and to delineate sex effects.Design, setting, participants, & measurements A population-based retrospective cohort study using The Health Improvement Network was performed. The median calendar year for the start of the observation period was 2004 (1994-2012). This study identified 51,785 participants with $1 of 87 diagnostic codes for urolithiasis and 517,267 randomly selected age-, sex-, and practice-matched participants. Cox regression was used to estimate the hazard ratio (HR) for first fracture. Fractures identified using diagnostic codes were classified by anatomic site.Results Median age was 53 years, and 67% of participants were men, confirming their greater urolithiasis burden. Median time from urolithiasis diagnosis to fracture was 10 years. The HR for fracture associated with urolithiasis differed by sex and age (P for interactions, P#0.003). In men, the adjusted HR was greatest in adolescence (1.55; 95% confidence interval [95% CI], 1.07 to 2.25) with an overall HR of 1.10 (95% CI, 1.05 to 1.16). Urolithiasis was associated with higher fracture risk in women aged 30-79 years (HR, 1.17-1.52), and was highest in women aged 30-39 years (HR, 1.52; 95% CI, 1.23 to 1.87). Peak background fracture rates were highest in boys aged 10-19 years and in women aged 70-79 years. The incidence per 10,000 person-years in participants with versus without urolithiasis was 392 versus 258 in male participants aged 10-19 years, and 263 versus 218 in women aged 70-79 years. Distribution of fracture site within sex did not differ between participants with versus without urolithiasis.Conclusions Urolithiasis was associated with higher incident fracture risk. The significantly higher risk at times of peak background fracture incidence in adolescent boys and elderly women has profound public health implications.

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Study of the incremental cost and clinical burden of hip fractures in postmenopausal women in the United Kingdom

Cited by 31 publications

References 17 publications

High impact exercise increased femoral neck bone mineral density in older men: A randomised unilateral intervention

High impact exercise increased femoral neck bone mineral density in older men: A randomised unilateral intervention

Models of care for the delivery of secondary fracture prevention after hip fracture: a health service cost, clinical outcomes and cost-effectiveness study within a region of England

Risk of Fracture in Urolithiasis

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