Study of the in Vitro Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia

Abstract

The present study investigated the in vitro antiprotozoal activity of sixteen selected medicinal plants. Plant materials were extracted with methanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxic activity was determined against MRC-5 cells to assess selectivity. The criterion for activity was an IC50 < 10 µg/mL (<5 µg/mL for T. brucei) and a selectivity index of ≥4. Antiplasmodial activity was found in theextracts of Prosopis juliflora and Punica granatum. Antileishmanial activity against L. infantum was demonstrated in Caralluma sinaica and Periploca aphylla. Amastigotes of T. cruzi were affected by the methanol extract of Albizia lebbeck pericarp, Caralluma sinaica, Periploca aphylla and Prosopius juliflora. Activity against T. brucei was obtained in Prosopis juliflora. Cytotoxicity (MRC-5 IC50 < 10 µg/mL) and hence non-specific activities were observed for Conocarpus lancifolius.

Atividade Leishmanicida in Vitro De Prosopis Juliflora(swartz)

“…Foram encontrados registros de atividade antiparasitária desta espécie, porém poucos trabalhos foram encontrados em relação a atividade leishmancida de P. juliflora. Musayeib et al (2012), registraram atividade leishmanicida do extrato metanólico das folhas de P. juliflora frente a formas promastigotas de L. infatum (CI 50 = 35±2,6 µg/mL). Comparando os resultados desta pesquisa, com os dos autores supracitado, é possível observar que os extratos e frações de P. juliflora, apresentaram atividade mais significativa frente à espécie L. amazonensis.…”

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

“…The criterion for activity was an IC 50 <10 µg/mL (<5 µg/mL for T. brucei) and a selectivity index >4. The antiplasmodial activity was detected in Amastigotes of T. cruzi and T. brucei [46].…”

The photosynthetic apparatus ofConocarpus lancifoliusEngl. (Combretaceae) suffers damage in soil contaminated with heavy metals

“…For instance, Al-Taweel et al (2016) reported a new ellagic acid derivative from C. lancifolius that shows anti-inflammatory, cytotoxic, and peroxisome proliferator activated D r a f t receptor (PPAR) agonistic activities. Furthermore, Al-Musayeib et al (2012) demonstrated antiplasmodial, antileishmanial, and antitrypanosomal activities in C. lancifolius, indicating their potential for human health benefits. In terms of ecosystem remediation, Yateem et al (2008) reported the rhizo-remediation of hydrocarboncontaminated soil by C. lancifolius and their results suggested that 85.7% of measurable total petroleum hydrocarbon could be degraded in rhizosphere soils associated with C.…”