Study of the fabrication of AISI 316L microneedle arrays

García-López, Erika; Siller, Héctor R.; Rodrı́guez, Ciro A.

doi:10.1016/j.promfg.2018.07.014

Cited by 22 publications

(23 citation statements)

References 21 publications

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“…The next interesting fabrication method is micromachining explored by Wang's group. [ 74,75 ] This method is a top‐down technique with the final structure produced by removal of a stock material to the desired geometry. The desired geometry is first virtually created in a 3D modeling software, and then transferred to the micro‐computer numerical control (CNC) machine that runs in XYZ axes while chipping off the materials from the stock material by the CNC bits installed on the tip of the moving CNC head.…”

Section: Microneedle Fabrication Methodsmentioning

confidence: 99%

Lab under the Skin: Microneedle Based Wearable Devices

Teymourian

Tehrani

Mahato

et al. 2021

Adv Healthcare Materials

184

140

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While the current smartwatches and cellphones can readily track mobility and vital signs, a new generation of wearable devices is rapidly developing to enable users to monitor their health parameters at the molecular level. Within this emerging class of wearables, microneedle‐based transdermal sensors are in a prime position to play a key role in synergizing the significant advantages of dermal interstitial fluid (ISF) as a rich source of clinical indicators and painless skin pricking to allow the collection of real‐time diagnostic information. While initial efforts of microneedle sensing focused on ISF extraction coupled with either on‐chip analysis or off‐chip instrumentation, the latest trend has been oriented toward assembling electrochemical biosensors on the tip of microneedles to allow direct continuous chemical measurements. In this context, significant advances have recently been made in exploiting microneedle‐based devices for real‐time monitoring of various metabolites, electrolytes, and therapeutics and toward the simultaneous multiplexed detection of key chemical markers; yet, there are several grand challenges that still exist. In this review, we outline current progress, recent trends, and new capabilities of microneedle‐empowered sensors, along with the current unmet challenges and a future roadmap toward transforming the latest innovations in the field to commercial products.

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Section: Microneedle Fabrication Methodsmentioning

confidence: 99%

Lab under the Skin: Microneedle Based Wearable Devices

Teymourian

Tehrani

Mahato

et al. 2021

Adv Healthcare Materials

184

140

View full text Add to dashboard Cite

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“…Tip radius is a feature that strongly depends on the manufacturing process. It has been reported that typical microneedles vary this characteristic from 1 to 25 μm [10], and other experimentations have reported tip radii above 50 μm [14]. It has been found that the force required for insertion scaled with tip sharpness thus relates to the force of insertion with pain [15,16].…”

Section: Introductionmentioning

confidence: 95%

Assessment of geometrical dimensions and puncture feasibility of microneedles manufactured by micromilling

Tamez-Tamez

Vázquez

Rodrı́guez

et al. 2023

Int J Adv Manuf Technol

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Microneedles are an emerging technology designed to deliver drugs into human tissue. In this work, we assess the microneedle’s manufacturability by employing micromilling with a minimum quantity lubrication (MQL) system. A set of AISI 316L square pyramidal microneedles was fabricated and characterized using dimensional and surface metrology. Needle height (Hn), base length (Lb), tip radius (Rt), and the tip’s angle (θ) were studied. Additionally, surface roughness was quantified to correlate surface topography damage with tool wear (Dr). Experimental data shows tip truncation after manufacturing 30 needles (i.e., a tip radius between ~32 μm and 49 μm for manufacturing 10 and 30 needles, respectively). Additionally, to evaluate the effect of the tip’s morphology on the proficiency of the microneedles for a puncture, a numerical analysis to study the impact of tip truncation length (Tt) on puncture with an in silico assessment using COMSOL Multiphysics was performed. Data and insights from this work suggest that micromilling microneedle arrays is viable, considering the number of needles machined according to the cutting parameters selected to ensure functionality.

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“…However, limited by material toughness and cutter size, the cutting accuracy is not high and the surface roughness of the fabricated MNs is not satisfactory [74]. In addition, the influence of blade wear on product quality should be taken into account when the blade is used for a long time [75]. The cutting method is usually suitable for materials with a certain degree of hardness, such as silicon and metal.…”

Section: Cuttingmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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Study of the fabrication of AISI 316L microneedle arrays

Cited by 22 publications

References 21 publications

Lab under the Skin: Microneedle Based Wearable Devices

Lab under the Skin: Microneedle Based Wearable Devices

Assessment of geometrical dimensions and puncture feasibility of microneedles manufactured by micromilling

Engineering Microneedles for Therapy and Diagnosis: A Survey

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