Study of the embryofoetotoxicity of α-terpinene in the rat

Araújo, Ivonete Batista de; Souza, Carolina Augusto de; De-Carvalho, Rosângela R.; Kuriyama, S.; Rodrigues, Rodrigo; Vollmer, R. S.; Alves, Eloisa Nunes; Paumgartten, Francisco José Roma

doi:10.1016/0278-6915(96)87358-3

Cited by 27 publications

(8 citation statements)

References 4 publications

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“…Latex-induced reductions in fetal body weight were only slight, and were not significant when the litter was taken as the statistical unit of analysis in the groups treated with 125 and 250 mg/kg. Thus, in this case, as in previous experiments with other substances (12)(13)(14), the proportion of fetuses showing signs of delayed ossification proved to be a more sensitive indicator of prenatal growth retardation than fetal weight at term.…”

Section: Discussionsupporting

confidence: 83%

Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide

Souza

De-Carvalho

Kuriyama

et al. 1997

Braz J Med Biol Res

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The crude latex of Crown-of-Thorns (Euphorbia milii var. hislopii) is a potent plant molluscicide and a promising alternative to the synthetic molluscicides used in schistosomiasis control. The present study was undertaken to investigate the embryofeto-toxic potential of E. milii latex. The study is part of a comprehensive safety evaluation of this plant molluscicide. Lyophilized latex (0, 125, 250 and 500 mg/kg body weight) in corn oil was given by gavage to Wistar rats (N = 100) from days 6 to 15 of pregnancy and cesarean sections were performed on day 21 of pregnancy. The numbers of implantation sites, living and dead fetuses, resorptions and corpora lutea were recorded. Fetuses were weighed, examined for external malformations, and fixed for visceral examination, or cleared and stained with Alizarin red S for skeleton evaluation. A reduction of body weight minus uterine weight at term indicated that E. milii latex was maternally toxic over the dose range tested. No latex-induced embryolethality was noted at the lowest dose (125 mg/kg) but the resorption rate was markedly increased at 250 mg/kg (62.5%) and 500 mg/kg (93.4%). A higher frequency of fetuses showing signs of delayed ossification (control: 17.4%; 125 mg/kg: 27.4% and 250 mg/kg: 62.8%; P < 0.05 vs control) indicated that fetal growth was retarded at doses > or = 125 mg latex/kg body weight. No increase in the proportion of fetuses with skeletal anomalies was observed at the lowest dose but the incidence of minor skeletal malformations was higher at 250 mg/kg body weight (control: 13.7%; 125 mg/kg: 14.8%; 250 mg/kg: 45.7%; P < 0.05 vs control). Since a higher frequency of minor malformations was noted only at very high doses of latex which are embryolethal and maternally toxic, it is reasonable to conclude that this plant molluscicide poses no teratogenic hazard or, at least, that this possibility is of a considerably low order of magnitude.

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Section: Discussionsupporting

confidence: 83%

Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide

Souza

De-Carvalho

Kuriyama

et al. 1997

Braz J Med Biol Res

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“…CEOs and their chemical compositions possess a wide spectrum of biological activities, including antimicrobial, 34,42−49 antioxidant, 50,51 anticancer, 52−55 anti-inflammatory, 56−60 insecticidal, 61−67 embryo-fetotoxicity, 68 and metabolism disorder regulating activity. 69−76 All of the bioactivities mentioned above are summarized in Table 1.…”

Section: ■ Introductionmentioning

confidence: 99%

Antifungal Activity of Citrus Essential Oils

Lei

et al. 2014

J. Agric. Food Chem.

176

126

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Citrus essential oils (CEOs) are a mixture of volatile compounds consisting mainly of monoterpene hydrocarbons and are widely used in the food and pharmaceutical industries because of their antifungal activities. To face the challenge of growing public awareness and concern about food and health safety, studies concerning natural biopreservatives have become the focus of multidisciplinary research efforts. In the past decades, a large amount of literature has been published on the antifungal activity of CEOs. This paper reviews the advances of research on CEOs and focuses on their in vitro and food antifungal activities, chemical compositions of CEOs, and the methods used in antifungal assessment. Furthermore, the antifungal bioactive components in CEOs and their potential mechanism of action are summarized. Finally, the applications of CEOs in the food industry are discussed in an attempt to provide new information for future utilization of CEOs in modern industries.

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“…Nevertheless, more and more studies, both in vitro and in vivo, have uncovered its toxic character [ 2 , 17 ]. Some of the first such studies were conducted by Araujo et al and presented the embryo foetotoxic impact of the terpene in pregnant rats [ 18 ]. The studies, based on gavage administration of the monoterpene to female rats from day 6 to 15 of pregnancy, (30, 60, 125 and 250 mg/kg body weight) revealed the maternally toxic effect of 125 and 250 mg/kg body weight of α-terpinene leading to a reduction of body weight.…”

Section: Toxicity Of Selected Monoterpenesmentioning

confidence: 99%

Toxicity of Selected Monoterpenes and Essential Oils Rich in These Compounds

Wojtunik-Kulesza

2022

Molecules

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Monoterpenes make up the largest group of plant secondary metabolites. They can be found in numerous plants, among others, the Lamiaceae family. The compounds demonstrate antioxidative, antibacterial, sedative and anti-inflammatory activity, hence, they are often employed in medicine and pharmaceuticals. Additionally, their fragrant character is often made use of, notably in the food and cosmetic industries. Nevertheless, long-lasting studies have revealed their toxic properties. This fact has led to a detailed analysis of the compounds towards their side effects on the human organism. Although most are safe for human food and medical applications, there are monoterpene compounds that, in certain amounts or under particular circumstances (e.g., pregnancy), can cause serious disorders. The presented review characterises in vitro and in vivo, the toxic character of selected monoterpenes (α-terpinene, camphor, citral, limonene, pulegone, thujone), as well as that of their original plant sources and their essential oils. The selected monoterpenes reveal various toxic properties among which are embryotoxic, neurotoxic, allergenic and genotoxic. It is also known that the essential oils of popular plants can also reveal toxic characteristics that many people are unaware of.

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Study of the embryofoetotoxicity of α-terpinene in the rat

Cited by 27 publications

References 4 publications

Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide

Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide

Antifungal Activity of Citrus Essential Oils

Toxicity of Selected Monoterpenes and Essential Oils Rich in These Compounds

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