Study of the efficacy of Coated VICRYL Plus® Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery

Efficacy of antimicrobial sutures in reducing surgical site infection during hernia surgery: a comparative study

“…17 Furthermore, apart from the prevention of infection, TC coated sutures inhibits the bacterial colonization, alters the cytokine levels which may prelude to accelerated wound healing. 11 In our study, the based on the Southampton wound scoring system there was no significant improvement in the wound healing in patients treated with TC coated sutures as that of the conventional sutures. Further, the duration of antibiotic administration post operatively was not decreased in TC coated sutured as that of the conventional suture.…”

“…The antimicrobial potential of TC in inhibiting bacterial adherence and microbial viability in the suture material has been well documented in invitro and preclinical studies. [9][10][11] Recently, studies have tried to use TC-coated suture in inguinal hernia surgery, and showed better cosmetic outcomes and efficiency in reducing SSI.…”

Prävention postoperativer Wundinfektionen

“…minimalinvasive Verfahren [156][157][158][159][160][161][162][163][164] können gegenüber den jeweiligen offenen Operationsverfahren einen infektionspräventiven Vorteil haben, dies jedoch nicht durchgehend [165]. [190,191]. Es könnte deshalb mit seiner Verwendung zur Reduktion des SSI-Risikos kommen.…”

Evaluation of risedronate as an antibiofilm agent

“…These include preventing the adherence of bacteria to surfaces or other bacteria, interrupting quorum-sensing mechanisms required for the formation of biofilm components, inhibiting biosynthesis of the extracellular components of the biofilm matrix, and employing enzymes that can degrade the biofilm matrix, rendering the bacteria accessible to biocides and/or immune clearance (Cegelski et al, 2008). In the field of healthcare, some of these approaches have been implemented by using topical antimicrobial ointments, using catheters provided with a surgically implanted cuff (Flowers et al, 1989), seeding catheters with avirulent urinary tract Escherichia coli isolates (Trautner et al, 2003;Trautner et al, 2007), and coating medical devices with antimicrobial agents (Darouiche et al, 1999;Johnson et al, 1999;Ahearn et al, 2000;Domenico et al, 2001;Edmiston et al, 2006;Gó mez-Alonso et al, 2007;Cobrado et al, 2012Cobrado et al, , 2013Azevedo et al, 2014).…”