Study of the Efficacy and Success Rate of Single Dose Oral Mifepristone and Vaginal Misoprostol v/s Vaginal Misoprostol alone for Second Trimester Termination of Pregnancy

Khairnar, Meetali Mukund; Patil, Ajay B.

doi:10.18311/mvpjms/2018/v5i2/11030

Cited by 4 publications

(1 citation statement)

References 9 publications

(11 reference statements)

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“…Some studies have shown that higher effectiveness of drugs administered was observed via vaginal route rather than oral one. [ 8 14 ] A study by Khairnar and Patil[ 15 ] stated that if the dose and the interval of drug administration in the sublingual and vaginal methods are correctly implemented, similar results on the efficacy of the drug for two routes are observed. The study by Imširija et al [ 16 ] indicated that there is no valuable research showing the comparison of effectiveness between the vaginal and oral methods during weeks 9 and 12 of pregnancy; however, overall, more success rate has been reported for the vaginal method.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

et al. 2020

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Background: This study was aimed at comparing the efficacy of different routes of misoprostol administration, including sublingual, oral, and vaginal, on the induction of medical abortion in the first trimester of pregnancy. Materials and Methods: This open-label, randomized clinical trial study was performed on 172 individuals in three parallel groups of vaginal, sublingual, and oral administration of misoprostol. The participants were randomized using permuted blocks of six. A dose of 600 μg of misoprostol every 6 h (maximum of 4 doses) was administrated to each group. Higham chart and demographic questionnaires were completed by the investigator. Data were analyzed using Stata software version 12. Results: The mean age of the participants was 29.81 ± 6.7 years, and the mean gestational age was 8.45 ± 2.32 weeks. We found a significant difference regarding the abortion success rate and the time interval between the administration of the drug among three groups ( P = 0.036 and < 0.001 in turn). There was no statistically significant difference between the three groups in terms of severity and duration of vaginal bleeding until day 7 after induction ( P = 0.091 and 0.143, respectively). Furthermore, we found statistically significant differences in some drugs, which induced side effects namely vomiting and headache, between the three groups ( P = 0.032 and 0.028 in turn). Conclusion: The findings suggest that vaginal administration of misoprostol is more successful than the sublingual and oral route for complete abortion; vaginal administration of misoprostol is an appropriate alternative to curettage.

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Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

et al. 2020

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Critical analysis of misoprostol versus mifepristone with misoprostol in medical termination of pregnancy

Nipanal,

Doddiah,

Talawar

2023

IJOGR

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Termination of pregnancy by any method before the viable period is called abortion. Medical methods can avoid complications of surgical method of abortion which has many disadvantages like perforation of uterus, hemorrhage, sepsis and increased morbidity. The WHO has approved mifepristone and misoprostol combination for medical abortion. 1. To compare the efficacy of Misoprostol versus combination of mifepristone with Misoprostol. 2. To asses the side effects of Misoprostol and combinationion of Mifepristone and Misoprostol.It is prospective observational study consisting of two groups with each 61 subjects of MTP patients. Group A (Misoprostol alone): Receive tablet misoprostol 600 microgram start placed per vaginally followed by 400 microgram misoprostol tablet placed per vaginally every 4 hourly up to maximum five doses. In case of first trimester cases 800 microgram tablet misoprostol placed per vaginally followed by 400 microgram misoprostol tablet placed per vaginally every 4 hourly up to maximum four doses. Group B (Mifepristone and Misoprostol): Receive tablet mifepristone 200mg orally on empty stomach. After 24 hours will receive tablet misoprostol as mentioned in group A. Misoprostol alone has success rate of 78.69% whereas combination with Mifepristone success was 93.44%. The mean Induction - abortion interval in misoprostol alone group was 11.803 hours and with mifepristone combination it was B5.623 hours. Medical termination of pregnancy by sequential administration of mifepristone with misoprostol has less induction abortion interval compared to using misoprostol alone. This combination has more success rate and also has lesser side effects.

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Study of the Efficacy and Success Rate of Mifepristone and Misoprostol v/S Misoprostol Alone in Mid-Trimester Abortion

Das

Dutta

Gogoi

2021

IJAR

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Objective- To compare the relative efficacy and success rate of combination of mifepristone and misoprostol with misoprostol alone in mid-trimester abortion by correlating induction abortion interval (IAI) between two study groups. Methods- A comparative study was carried out by dividing 100 women seeking for abortion into two groups (50 each). GroupA received 200mg mifepristone orally followed by 600mcg misoprostol vaginally (24 hours later) which was repeated 4 hourly by 400mcg sublingual misoprostol upto a maximum of 5 doses. GroupB received 600mcg misoprostol vaginally and dose was repeated 4 hourly by 400mcg of misoprostol sublingually. Result- the success rate in GroupA was 100%, whereas in Group B was 94%. The mean IAI in GroupA was lesser (10.8 hours) as compared to GroupB (13.5 hours) p value 0.01. The mean dose of misoprostol in GroupA was 1400mcg compared to GroupB 1760mcg (p value 0.0001). Conclusion- Pre-treatment with mifepristone significantly shortens the IAI and increase the successful abortion rate.

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Study of the Efficacy and Success Rate of Single Dose Oral Mifepristone and Vaginal Misoprostol v/s Vaginal Misoprostol alone for Second Trimester Termination of Pregnancy

Cited by 4 publications

References 9 publications

Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

Critical analysis of misoprostol versus mifepristone with misoprostol in medical termination of pregnancy

Study of the Efficacy and Success Rate of Mifepristone and Misoprostol v/S Misoprostol Alone in Mid-Trimester Abortion

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