Study of the effects ofMorinda morindoïdes (Back) on the immune system

Mankele, R.; Ouamba, J. M.; Abena, Ange Antoine; Yala, F.

doi:10.1007/s10298-006-0154-x

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…While the literature data point out the presence of saponins, flavonoids, terpenes, steroids, tannins and anthraquinones, the absence of anthocyanes and the doubtful presence of alkaloids in Morinda morindoides leaves (Kambu, 1990), extensive phytochemical studies on this medicinal plant part have led to the isolation and structure elucidation of flavonoids (Cimanga et al, 1995a(Cimanga et al, , 1997, iridoids (Cimanga et al, 2003) and anthraquinones (Cimanga et al, 2008). Some interesting biological activities related to some of its traditional uses including the in vitro and in vivo antimalarial (Onabanjo, 1983;Cimanga et al, 2008), the in vitro anticomplementary (Cimanga et al, 1995b(Cimanga et al, , 1997(Cimanga et al, , 2003, antioxidative ), cardioinhibitory (N'Guessan et al, 2002, antiamoebic (Cimanga et al, 2006) and immunologic (Mankele et al, 2006) activities, were previously reported. However, the plant part has not been studied for its putative antispasmodic activity.…”

Section: Introductionmentioning

confidence: 89%

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Cimanga

Mukenyi

Kambu

et al. 2010

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 89%

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Cimanga

Mukenyi

Kambu

et al. 2010

Journal of Ethnopharmacology

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“…Also, ten flavonoids and eight iridoid glycosides have been isolated from the butanol and ethyl acetate fractions by Cimanga et al (1999). Some interesting biological activities related to some of its traditional uses, including antioxidative (Cimanga et al, 1999), cardioinhibitory (N'Guessan et al, 2002, anticomplementary (Cimanga et al, 2003), antiamoebic (Cimanga et al, 2006), immunologic (Mankele et al, 2006), antimalarial (Cimanga et al, 2008) and spasmolytic (Cimanga et al, 2010) activities were previously reported. The present work was planned to examine in vitro the laxative activity of total protein extract of Morinda morindoides and its mechanism on duodenal smooth muscle contractility.…”

Section: Introductionmentioning

confidence: 98%

Cholinergic and anticholinesterase activities of total protein extract of <em>Morinda morindoïdes</em> on isolated rabbit duodenum

Gboko¹,

Souleymane²,

Calixte³

et al. 2012

Int. J. Bio. Chem. Sci

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Traditional herbal medicines such as Morinda morindoïdes are used for treatment of intestinal disorders including constipation in Ivory Coast. The aim of present study was to investigate the effect of total protein of Morinda morindoïdes extract (PT-Mm) on rabbit duodenum contractility and the involved possible mechanism(s). PT-Mm was extracted according to the saturation method of Dawson with ammonium sulfate. The cholinergic effect of the extract was determined by the in vitro organ bath method. The acetylcholinesterase (AChE) extracted from rabbit duodenum and it activity was determined by Ellman's assay using acetylthiocholine (ASCh) as substrate. PT-Mm concentrations (40, 80, 120 and 200 µg/mL) showed dose-dependent effect a both tonicity and amplitude of the duodenum spontaneous contractions. The effective concentration which induces 50% effect of PT-Mm (EC 50) was obtained with 68.57 ± 0.89 µg/mL. The antagonist tests carried out showed a considerable reduction (90%) in the amplitudes of duodenal contractions in the presence of atropine, but with nifedipine, the contractions were completely inhibited. PT-Mm also exerted non-competitive inhibition on AChE (Vmax = 5687 mM/min and K M = 578 µM). These results suggest that PT-Mm could stimulate duodenum smooth muscle contraction because it contains anti-AChE and cholinomimetic substances which, through muscarinic receptors, increase Ca 2+ mobilization from extracellular. Therefore, PT-Mm could be used as a laxative, due to its stimulating effects on duodenal contractility.

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“…Inflammation and immunosuppression were observed in the occurrence of metabolic diseases such as diabetes mellitus (Tanaka, 2008;Rubinstein et al, 2008) and dyslipidemia (Kakei et al, 2009;Zhao, 2009). Plants that have anti-inflammatory and immunogenic are searched for in the treatment of inflammatory diseases and immunodeficiency in humans (Gutpa et al, 1971;Mankele et al, 2006). Several studies have highlighted the antiinflammatory properties of certain plants (Holanda et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…In these studies, inflammation was induced in experimental animals to test for plants that may possess anti-inflammatory properties. But study on the evaluation of immunogenic activity of plants such as Mankele et al (2006) , Kra et al (2007) , have not undergone prior immunosuppression in animals. Whereas it is logical and normal that animal that is used to assess the immunogenic properties of plants should be put first in a state of reversible immunocompromised.This will allow for effective verification in vivo of immunogenic properties of plants if we noticed any stimulation of immunological markers in animals.…”

Section: Introductionmentioning

confidence: 99%

Lipids, glucose parameters and reversible immunosuppression induced by Methylprednisolone on healthy rabbits

Félix¹,

Yapo²,

Philippe³

et al. 2011

ABJNA

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Single doses of Methylprednisolone hemisuccinate were tested in healthy rabbits. This study was conducted to determine the dose or doses that induce significant immunosuppression without significantly altering the serum levels of lipids and glucose within a relatively long period. Thus, four concentrations of methylprednisolone (2.5, 5, 10 and 15mg/kg body weight) were tested on four groups of six rabbits and a control group (0.9% NaCl). The results of this study showed that only concentrations of 10 and 15 mg / kg body weight induced a significant immunosuppression within seven days (P <0.05). Furthermore, with a dose of 15mg/kg body weight serum concentrations of triglycerides and glucose were increased significantly (P <0.05) while other doses had no effect on other biological parameters (P> 0.05). The results of this study suggest that the dose of 10mg/kg body weight could be given as a dose inducing reversible immunosuppression without significantly altering the lipid and glucose parameters. The increase of lipids and glucose may cause diseases such as dyslipidemia and diabetes which could give rise to an irreversible immunosuppression.

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Study of the effects ofMorinda morindoïdes (Back) on the immune system

Cited by 4 publications

References 5 publications

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Cholinergic and anticholinesterase activities of total protein extract of <em>Morinda morindoïdes</em> on isolated rabbit duodenum

Lipids, glucose parameters and reversible immunosuppression induced by Methylprednisolone on healthy rabbits

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