Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome

Fujimoto, Makoto; Tsuneyama, Koichi; Chen, Shao-Yuan; Nishida, Takeshi; Chen, Jiun-Liang; Chen, Yen‐Chen; Fujimoto, T; Imura, Johji; Shimada, Yutaka

doi:10.1155/2012/892697

Cited by 34 publications

(24 citation statements)

References 42 publications

(43 reference statements)

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“…Generally, the observed levels of ALT and AST found in our controls and orally treated groups are lower than what is observed in other studies, [9][10][11][12] but we ascribe the differences in absolute values to differences in the experimental procedures and mouse strains.…”

Section: Discussioncontrasting

confidence: 90%

Safety of the Cell-Penetrating Peptide Penetratin as an Oral Absorption Enhancer

2015

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Novel delivery technology using cell-penetrating peptides (CPPs) have recently shown their potential and are emerging as promising candidates for an oral protein and peptide delivery systems. As with for the development of any absorption enhancer that is meant to function across an epithelial layer covering a surface highly exposed to pathogens such as the intestines, concern arises about the safety of such enhancers. The purpose of this study was to investigate the effect of 7 d of consecutive oral administrations of CPPs and a typical enterotoxin, lipopolysaccharide (LPS) to mice to determine the degree, if any, of damage caused to the hepatic tissue. Following the 7-d dosing regimen, we could not detect significantly increased levels of the liver enzymes alanine aminotransferase and aspartate aminotransferase in plasma of mice treated with CPP and LPS compared to the controls, whereas heightened levels were observed in animals receiving the bile salt. In conclusion, the repeated use of CPPs as an oral absorption enhancer for macromolecules was found to be a safe strategy.

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Section: Discussioncontrasting

confidence: 90%

Safety of the Cell-Penetrating Peptide Penetratin as an Oral Absorption Enhancer

2015

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“…These components had been proved to ameliorate metabolic syndrome. GABA could improve metabolic syndrome (Matsumoto & Takekawa, ), and improve hyperglycemia through increasing insulin secretion (Fujimoto et al, ). Meanwhile, γ‐oryzanol, flavonoids, or anthocyanidin was an effective antioxidant, and also possessed anti‐metabolic syndrome activities (Ayoub et al, ; Si et al, ).…”

Section: Discussionmentioning

confidence: 99%

Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome

Hao

Lin

et al. 2019

J Food Biochem

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This study examined the effect of pre‐germinated brown rice extract (PGBRE), containing no dietary fibers, but γ‐oryzanol, γ‐aminobutyric acid (GABA), flavonoids, and anthocyanidin, on high‐fat‐diet (HFD)‐induced metabolic syndrome. C57BL/6 mice were divided into five groups: regular diet, HFD, HFD with oral PGBRE 30, 300, or 600 mg/kg per day for 18 weeks. In the HFD group, higher body and liver weight gain, hyperglycemia, HbA1c, and insulin; higher TG, TC, LDL‐C, non‐HDL, atherosclerosis index, lower HDL, adiponectin in blood; higher TG in the liver; higher TG, bile acid in feces; and lower protein levels of AMP‐activated protein kinase, insulin receptor, insulin receptor substrate‐1, insulin receptor substrate‐2, peroxisome proliferator‐activated receptor‐γ, phosphatidylinositol‐3‐kinase, Akt/PKB, glucose transporter‐1, glucose transporter‐4, glucokinase in the skeletal muscle; lower glucagon‐like peptide 1 (GLP‐1) in the intestine; higher sterol regulatory element‐binding protein‐1 (SREBP‐1), stearoyl‐CoA desaturase 1 (SCD‐1), fatty acid synthase (FAS), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase, proprotein convertase subtilisin/kexin type 9 (PCSK9), and lower PPAR‐α, low‐density lipoprotein receptor, cholesterol‐7α‐hydroxylase in the liver; higher SREBP‐1, SCD‐1, FAS, and lower PPAR‐α, adiponectin in the adipose tissue were found. In HFD + PGBRE groups, the above biochemical parameters were improved. Practical applications According to the results, we suggested that dietary fibers played a minor role in this study. Extract of PGBR, excluding dietary fiber, showed beneficial activity to ameliorate metabolic syndrome. γ‐oryzanol, GABA, flavonoids, and anthocyanidin in PGBRE can inhibit HFD‐induced metabolic syndrome and we demonstrated clearly its action mechanisms. This is the first report to examine the relation between PGBRE, GLP‐1, and PCSK9. Taken together, PGBRE can potentially be used to develop a good supplement to control metabolic syndrome.

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“…has historically been marketed in Asian countries for its medicinal properties and used as a food preservative to maintain meat flavor and color (Fujimoto et al, 2012). It is considered an antioxidant or medicinal agent because of its unsaturated fatty acids may have serum lipid-lowering effects (Wang et al, 1997;Arunachalam & Narmadhapriya, 2011).…”

Section: Growth Performance and Fatty Acid Profiles Of Broilers Givenmentioning

confidence: 99%

Growth Performance and Fatty Acid Profiles of Broilers Given Diets Supplemented with Fermented Red Ginseng Marc Powder Combined with Red Koji

Chung

Choi

2016

Rev. Bras. Cienc. Avic.

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KeywordsFermented red ginseng marc powder, red koji, red ginseng marc, growth performance, fatty acid. ABSTRACTIn this study, 240 one-d-old Arbor Acres broiler chicks (160 males and 80 females) were randomly allocated in a completely randomized design with four treatments and four replicates. Broilers were fed from hatching to 28 d of age four diets: a basal diet (control), 2% red ginseng marc, 1% fermented red ginseng marc with red koji, and 2% liquid red ginseng. Growth performance and fatty acid profiles in broiler were evaluated. Supplementing diets with different types of red ginseng did have significant effects (p<0.05) on initial body weight, due to differences in the birth weights of birds, including weight gain, and mortality. However, no significant differences between the treatments (p>0.05) were found for final body weight, feed intake, and feed conversion. In addition, supplementing broiler diets with different types of red ginseng did not significantly influence (p>0.05) fatty acid profiles in either breast or thigh meats. We concluded that growth performance (weight gain and mortality) was most enhanced in diets supplemented with 1% fermented red ginseng powder combined with red koji.

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Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome

Cited by 34 publications

References 42 publications

Safety of the Cell-Penetrating Peptide Penetratin as an Oral Absorption Enhancer

Safety of the Cell-Penetrating Peptide Penetratin as an Oral Absorption Enhancer

Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome

Growth Performance and Fatty Acid Profiles of Broilers Given Diets Supplemented with Fermented Red Ginseng Marc Powder Combined with Red Koji

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