Study of the Effective Range of Drug Level Using a Novel Nano Co-polymer-Mefenamic Acid

Abstract

In the present work, the work is divided into two parts, the first include synthesis a novel nano co-polymer by the esterification reaction between phthalic anhydride and glycerol, as it was characterized via fourier transform infrared (FTIR), proton nuclear magnetic resonance (1HNMR), carbon-13 nuclear magnetic resonance (13CNMR), atomic force microscopy (AFM) and transmission electron microscopy (TEM) techniques. The second parts, mefenamic acid drug reaction with novel nano co-polymer by esterification reaction which synthesis in first stage to produced novel nano co-polymer mefenamic acid drug. because the urgent need to retain the drug within the effective range for longer time, this driving us to look for a new optimization method for drug release; therefore, the study included, the study of drug release in two values of pH 7.5 and 5, where the choice of these two values depends on that the pH of the extracellular tumor is in the range of 6.5–7, while the endosome and lysosome are 4.5–5.5. The study gave great results, by linking the drug (mefenamic acid) with the nano co-polymer.