Study of the effect of standardized chemotherapy order forms on prescribing errors and anti-emetic cost

Sano, Harold S.; Waddell, J. Aubrey; Solimando, Dominic A.; Doulaveris, Paula; Myhand, Rickey

doi:10.1191/1078155205jp149oa

Cited by 25 publications

(12 citation statements)

References 63 publications

(4 reference statements)

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“…Clinically, vomiting and nausea are frequently observed with the use of cytotoxic chemotherapy agents (e.g., Ettinger et al, 2008; Hesketh, 2008). Antiemetic drugs are not always effective for controlling emesis, can affect the efficacy of other treatments, pose potential health risks, and are expensive (Aapro, 2002; Candiotti et al, 2007; Llanes et al, 2006; Parsons et al, 2000; Sano et al, 2005; Twycross, 1994; Zhang et al, 2006a; Zhang et al, 2006b). Therefore, it is important to find better ways to control these side effects.…”

Section: Introductionmentioning

confidence: 99%

Computerized detection and analysis of cancer chemotherapy-induced emesis in a small animal model, musk shrew

Huang

Meyers

Henry

et al. 2011

Journal of Neuroscience Methods

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Vomiting is a common side effect of cancer chemotherapy and many drug treatments and diseases. In animal studies, the measurement of vomiting usually requires direct observation, which is time consuming and often lacks temporal precision. Musk shrews have been used to study the neurobiology of emesis and have a rapid emetic episode (~1 s for a sequence of retching and expulsion). The aims of the current study were to develop a method to automatically detect and characterize emetic episodes induced by the cancer chemotherapy agent cisplatin. The body contour in each video frame was tracked and normalized to a parameterized shape basis. The tracked shape was projected to a feature space that maximizes the shape variations in the consecutive frames during retching. The resulting one dimensional projection was sufficient to detect most emetic episodes in the acute (peak at 2 h) and delayed (peak at 54 h) phases after cisplatin treatment. Emetic episodes were relatively invariant in the number of retches (~6.2), duration (~1.2 s), inter-retch interval (~198 ms), and amplitude during the 72 h after cisplatin treatment. This approach should open a new vista into emesis research to permit tracking and analysis of emesis in small animal models and facilitate the development of new antiemetic therapies. These results also yield a better understanding of the brain's central pattern generator for emesis and indicate that the retching response in the musk shrew (at ~5.4 Hz) is the fastest ever recorded in a free-moving animal.

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Section: Introductionmentioning

confidence: 99%

Computerized detection and analysis of cancer chemotherapy-induced emesis in a small animal model, musk shrew

Huang

Meyers

Henry

et al. 2011

Journal of Neuroscience Methods

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“…'s quality improvement project to reduce medication errors 96 and Sano et al on standardized chemotherapy order forms to reduce errors in the prescribing of antineoplastic medication. 91 Six studies (21%) addressed more than one issue of suboptimal use of medicines. 86,88,91,93,94,98 No study evaluated insufficient prescribing of low-cost generics.…”

Section: Resultsmentioning

confidence: 99%

“…91 Six studies (21%) addressed more than one issue of suboptimal use of medicines. 86,88,91,93,94,98 No study evaluated insufficient prescribing of low-cost generics. There was approximately a 50:50 split on whether studies were specific to a disease area or generic.…”

Section: Resultsmentioning

confidence: 99%

“…7,26–28,49 Most cost-effectiveness studies (19, 66%) conducted a within-trial cost-effectiveness analysis using data from a single RCT 86,87,100,102,105,106,112,113 or a non-randomized study, such as before and after 90,96,99,101,103,114 or cohort studies. 88,89,91,95,110 Eleven cost-effectiveness studies (38%) used a model, either based on a single study, 92,104 a review of the literature 93,97,107,108,109,111 or from expert evidence elicitation. 94 …”

Section: Resultsmentioning

confidence: 99%

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The economics of medicines optimization: policy developments, remaining challenges and research priorities

Faria¹,

Barbieri²,

Light³

et al. 2014

British Medical Bulletin

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BackgroundThis review scopes the evidence on the effectiveness and cost-effectiveness of interventions to improve suboptimal use of medicines in order to determine the evidence gaps and help inform research priorities.Sources of dataSystematic searches of the National Health Service (NHS) Economic Evaluation Database, the Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effects.Areas of agreementThe majority of the studies evaluated interventions to improve adherence, inappropriate prescribing and prescribing errors.Areas of controversyInterventions tend to be specific to a particular stage of the pathway and/or to a particular disease and have mostly been evaluated for their effect on intermediate or process outcomes.Growing pointsMedicines optimization offers an opportunity to improve health outcomes and efficiency of healthcare.Areas timely for developing researchThe available evidence is insufficient to assess the effectiveness and cost-effectiveness of interventions to address suboptimal medicine use in the UK NHS. Decision modelling, evidence synthesis and elicitation have the potential to address the evidence gaps and help prioritize research.

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“…Several authors have reported a reduction in medication errors [6][7][8][9] and improvement in the completeness of prescriptions, 9,10 as well as greater adherence to institutional policies and guidelines [11][12][13] and increased efficiency with the use of preprinted medication order forms. Several authors have reported a reduction in medication errors [6][7][8][9] and improvement in the completeness of prescriptions, 9,10 as well as greater adherence to institutional policies and guidelines [11][12][13] and increased efficiency with the use of preprinted medication order forms.…”

Section: Management Consultationmentioning

confidence: 99%

Using preprinted medication order forms to improve the safety of investigational drug use

Tamer

Shehab²

2006

American Journal of Health-System Pharmacy

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The Management Consultation column gives readers an opportunity to obtain advice on common management problems from pharmacists practicing in health systems.AJHP readers are invited to submit questions for this column. Selected questions will be forwarded to one or two experts in the field, who will prepare brief responses for publication. Questions should be narrow in scope, such that they can be answered in approximately 500 words. Responses will be sent to the inquirer before publication. Readers are also invited to comment on the answers of consultants; such comments will be considered for the Letters column.Suggestions for topics should be submitted to AJHP,

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Study of the effect of standardized chemotherapy order forms on prescribing errors and anti-emetic cost

Abstract: SCOFs significantly reduced serotonin antagonist anti-emetic cost and prescribing error rate over a four-month period.

Cited by 25 publications

References 63 publications

Computerized detection and analysis of cancer chemotherapy-induced emesis in a small animal model, musk shrew

Computerized detection and analysis of cancer chemotherapy-induced emesis in a small animal model, musk shrew

The economics of medicines optimization: policy developments, remaining challenges and research priorities

Using preprinted medication order forms to improve the safety of investigational drug use

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