Study of the effect of active pharmaceutical ingredients of various classes of BCS on the parameters of thermosensitive systems based on poloxamers

Bakhrushina, E.O.; Khodenok, A.I.; Pyzhov, V.S.; Solomatina, P.G.; Demina, N.B.; Korochkina, T.V.; Krasnyuk, I.I.

doi:10.1016/j.jsps.2023.101780

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The tests were performed at 20 °C, over a range of shear rates from 0 to 300 s −1 for 60 s. To obtain average results, three measurements were taken for each sample after half an hour of relaxation. The stability of the index was determined by calculating the plastic viscosity using the Casson model [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach

Bakhrushina,

Mikhel,

Kondratieva

et al. 2024

Polymers

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The rapid growth in the prevalence of infectious diseases requires timely action from drug developers. In recent years, the COVID-19 pandemic has demonstrated the unpreparedness of the population for such emergencies. The introduction of modern methods of Design of Experiments (DoE) is required to accelerate the process of drug development and bring a drug to market. The main objective of this study was to develop an ion-triggered in situ system for intranasal delivery of VLP using a Quality by Design approach. Based on a literature review and initial studies, the key QTPP, CQA, CPP, and CMA were identified to develop a novel delivery system for virus-like particles. As a result of the studies on the quality attributes of the developed delivery system, an ion-triggered in situ gel meeting all the specified parameters was obtained using the Quality by Design method.

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Section: Methodsmentioning

confidence: 99%

Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach

Bakhrushina,

Mikhel,

Kondratieva

et al. 2024

Polymers

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Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation

Mikhel,

Bakhrushina,

Petrusevich

et al. 2024

Pharmaceutics

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Recently, ribavirin has demonstrated effectiveness in treating glioblastoma through intranasal administration utilizing the nose-to-brain delivery route. Enhancing ribavirin’s bioavailability can be achieved by utilizing intranasal stimuli-responsive systems that create a gel on the nasal mucosa. The research examined thermosensitive, pH-sensitive, and ion-selective polymers in various combinations and concentrations, chosen in line with the current Quality by Design (QbD) approach in pharmaceutical development. Following a thorough assessment of key parameters, the optimal composition of gellan gum at 0.5%, Poloxamer 124 at 2%, and purified water with ribavirin concentration at 100 mg/mL was formulated and subjected to in vivo testing. Through experiments on male rats, the nose-to-brain penetration mechanism of the active pharmaceutical ingredient (API) was elucidated, showcasing drug accumulation in the olfactory bulbs and brain.

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Study of the effect of active pharmaceutical ingredients of various classes of BCS on the parameters of thermosensitive systems based on poloxamers

Cited by 2 publications

References 20 publications

Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach

Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach

Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation

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