Study of the effect of polybutylcyanoacrylate nanoparticles and their metabolites on the primary immune response in mice to sheep red blood cells

Simeonova, Margarita; Chorbadjiev, K.G.; Antcheva, M.

doi:10.1016/s0142-9612(98)00126-4

Cited by 16 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, if administered intravascularly to the rats, N-butyl-2-cyanoacrylate induces only mild eosinophilic inflammation during the first day and after 7 days the tissue reaction is minimal [38]. However, small particles of cyanoacrylates can modulate immune response to external antigens as demonstrated by Simeonova et al [39]. Currently it is believed that the adjuvant effect of synthetic materials in stimulating dendritic cells and the adaptive immune response to co-expressed (auto)antigens may be more important than was previously thought [40].…”

Section: Issues Of Immune Response To Foreign Proteins and Biomateriamentioning

confidence: 99%

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Uibo

Laidmäe

Sawyer

et al. 2009

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

View full text Add to dashboard Cite

Polymeric scaffolds formed from synthetic or natural materials have many applications in tissue engineering and medicine, and multiple material properties need to be optimized for specific applications. Recent studies have emphasized the importance of the scaffolds’ mechanical properties to support specific cellular responses in addition to considerations of biochemical interactions, material transport, immunogenicity, and other factors that determine biocompatibility. Fibrin gels formed from purified fibrinogen and thrombin, the final two reactants in the blood coagulation cascade, have long been shown to be effective in wound healing and supporting the growth of cells in vitro and in vivo. Fibrin, even without additional growth factors or other components has potential for use in neuronal wound healing in part because of its mechanical compliance that supports the growth of neurons without activation of glial proliferation. This review summarizes issues related to the use of fibrin gels in neuronal cell contexts, with an emphasis on issues of immunogenicity, and considers the potential advantages and disadvantages of fibrin prepared from non-mammalian sources.

show abstract

Section: Issues Of Immune Response To Foreign Proteins and Biomateriamentioning

confidence: 99%

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Uibo

Laidmäe

Sawyer

et al. 2009

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

View full text Add to dashboard Cite

show abstract

“…1,9,10 Moreover, the toxicity is considered low in the case of multiple dosing (chronic treatment; e.g., LD 50 of poly(isobutylcyanoacrylate) in rats: 242 mg/kg), as the overloading of cells with slowly degrading polyesters is avoided. [11][12][13] In addition, the recovery of cells after the metabolization of the nanoparticles (NPs) takes place easily in vivo due to the considerable low contact time with the degradation products, as they are taken away from their degradation site. 10 Several clinical trials have also highlighted the good tolerance of these drug carriers.…”

Section: Introductionmentioning

confidence: 99%

Engineering of Poly(butylcyanoacrylate) Nanoparticles for the Enhancement of the Antitumor Activity of Gemcitabine

Arias¹,

Gallardo²,

Ruíz³

2009

Biomacromolecules

View full text Add to dashboard Cite

To increase the antitumor activity of gemcitabine along with overcoming its important drawbacks (poor biological half-life and the induction of resistance), we investigated a colloidal carrier based on biodegradable poly(butylcyanoacrylate) nanoparticles. Two gemcitabine loading methods were extensively analyzed: (i) surface adsorption in already formed nanoparticles after incubation in a drug solution; and (ii) gemcitabine addition before the anionic emulsion/polymerization process of the butylcyanoacrylate monomer and subsequent drug trapping into the polymeric network. The latter yielded a higher gemcitabine loading and a sustained release profile. The main factors determining the gemcitabine entrapment into the polymer network and the release kinetic of gemcitabine were analyzed. The cytotoxicity of gemcitabine-loaded polymer was tested in sensitive murine leukemia L1210 wt cells, showing similar activity to the free drug. Following intravenous treatment of mice bearing aggressive leukemia L1210 wt subcutaneous tumors, gemcitabine-loaded poly(butylcyanoacrylate) nanoparticles displayed significantly greater antitumor activity compared to the free chemotherapy agent. This was confirmed by histology studies, suggesting the potential of this gemcitabine delivery system for the efficient treatment of cancer.

show abstract

Biodegradation of Poly(alkylcyanoacrylates)

Vauthier

Couvreur

2002

Biopolymers Online

View full text Add to dashboard Cite

Introduction Historical Outline Synthesis and Purification of Alkylcyanoacrylate Monomers Polymer Synthesis General Considerations Bulk Polymerization Polymerization in Organic Solvents Emulsion Polymerization: Preparation of Matricial PACA Nanoparticles (Nanospheres) Interfacial Polymerization: Preparation of Reservoir‐Type PACA Nanoparticles (Nanocapsules) Synthesis of Amphiphilic Block Copolymers Containing PACA Segments World Market Characterization and Methods of Analysis Stability and Mechanism of Degradation Toxicity Application of PACA in the Design of Drug Delivery Systems Use of “Conventional” PACA Nanoparticles From “Conventional” to Targeted Systems Patent Overview Outlook and Perspectives

show abstract

Study of the effect of polybutylcyanoacrylate nanoparticles and their metabolites on the primary immune response in mice to sheep red blood cells

Cited by 16 publications

References 5 publications

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Engineering of Poly(butylcyanoacrylate) Nanoparticles for the Enhancement of the Antitumor Activity of Gemcitabine

Biodegradation of Poly(alkylcyanoacrylates)

Contact Info

Product

Resources

About