Study of the Effect of Dexmedetomidine in Reducing Hemodynamic Responses to General Anesthesia for Elective Cesarean Section in Patients with Preeclampsia

Abstract

Background: Depending on the effect of dexmedetomidine in haemodynamic stability, it was started to be used as a sedative prior to and/or during surgical and other procedures in non-intubated adult and pediatric patients. In 2009, dexmedetomidine has been successfully used in laboring parturients. It provides maternal hemodynamic stability, anxiolysis, and stimulation of uterine contractions. Literature describes that dexmedetomidine has a high placental retention and does not cross the placenta, with less incidence of fetal bradycardia. We hypothesized that dexmamedetomidine would be effective in reducing the maternal hemodynamic responses to elective cesarean section in preeclmaptic patients without adverse neonatal effects.

Remifentanil vs dexmedetomidine for severely preeclamptic parturients scheduled for cesarean section under general anesthesia: A randomized controlled trial

“…Also, the results of the present study were in agreement with those of the study done by Saleh ElSayed [27] which showed that dexmedetomidine infusion of 0.4 lg/kg/h was superior to fentanyl single dose of 1 lg/kg to suppress the hemodynamic response to surgical stimulation in preeclamptic parturients underwent C.S. under G.A.…”

“…Several studies successfully used dexmedetomidine for labor analgesia or CS under GA, or to improve the quality of pain relief with opioid-based analgesia [23,24]. Other studies employed dexmedetomidine in the healthy [25] and the preeclamptic [26,27] parturients for control of maternal hemodynamics. Later on, a study carried out on 2015, compared the efficacy of remifentanil on hemodynamics, depth of anesthesia, anesthetic consumption and neonatal outcome with that of dexmedetomidine in non-preeclamptic parturients [28].…”