Study of the clinical usefulness of a dental drug system for selective reduction of mutans streptococci using a case series

Tamaki, Yoh; Nomura, Yasuo; Takeuchi, Hiroaki; Ida, Hirohisa; Arakawa, Hirohisa; Tsurumoto, Akihisa; Kumagai, Toru; Hanada, Nobuhiro

doi:10.2334/josnusd.48.111

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…The use of antimicrobial agents reduce cariogenic activity by altering composition of pathogenic bacteria in dental biofilm. This ecological modification of the biofilm may balance the process of demineralization and remineralization between the dental surface and the adjacent plaque [15,19,22]. Among the antimicrobial agents available for dental use, CHX, which is particularly sensitive to mutans streptococci, is the most commonly used to control cariogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial

Shimpo

Nomura

Sekiya

et al. 2022

JCM

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(1) Background: The aim of this study was to assess the preventive effect of tooth surface disinfection treatment, in addition to fluoride application, during fixed orthodontic treatment. (2) Methods: An open label randomized control trial for the evaluation of the dental caries preventive procedure was performed for the patients with high caries risk who had been visited at Department of Orthodontics, Tsurumi University Dental Hospital for orthodontics treatment. The follow-up period was six months. White spot lesions (WSLs) were evaluated by quantitative light-induced fluorescence (QLF). Cariogenic bacteria were monitored and evaluated by bacterial culture. In addition, the oral microbiome was evaluated by a next-generation sequence (NGS). (3) Results: By the mixed effect modeling, tooth surface disinfection treatment significantly reduced cariogenic bacteria and all parameters obtained by QLF. (4) Conclusions: Tooth surface disinfection treatment, in addition to PMTC and fluoride application, were effective for dental caries prevention and keeping a healthy microbiome during orthodontic treatment.

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Section: Introductionmentioning

confidence: 99%

Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial

Shimpo

Nomura

Sekiya

et al. 2022

JCM

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“…In addition, the safety of using CHX on various fixed orthodontic appliances was not reported. It is of prime importance to investigate all the possible adverse factors, which may increase friction (19,20) between orthodontic wires and brackets because it may jeopardize the final outcome of orthodontic treatment planning (19,(21)(22)(23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

Effects of chlorhexidine (gel) application on bacterial levels and orthodontic brackets during orthodontic treatment

et al. 2016

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The objectives of this study were to evaluate the effects of applying 0.50% chlorhexidine (CHX) gel using the dental drug delivery system (3DS) on salivary Streptococcus mutans (S. mutans) and on the surface topography of metal and ceramic orthodontic brackets. The study involved 20 orthodontic patients with high levels of salivary S. mutans. The patients were treated with professional mechanical tooth cleaning followed by application of 0.50% CHX using individual trays (3DS). Salivary S. mutans levels were repeatedly measured 1, 2, 4, and 8 weeks post-treatment. In vitro study utilized forty ceramic and metallic brackets that were immersed in 0.50% CHX gel for 10 min, whereas another untreated forty brackets served as controls. The frictional resistances of stainless steel wires to the brackets before and after CHX treatment were recorded using a universal testing machine. Scanning electron microscopy was used to compare changes in the surface topography of brackets. Statistical analyses were used to determine the effect of CHX on bacterial count and to evaluate the effect of CHX on frictional resistance. According to the results of this study, S. mutans levels were reduced significantly (P < 0.05). There were no significant changes in the frictional resistance and surface topography of brackets before or after application of CHX. (J Oral Sci 58, [35][36][37][38][39][40][41][42] 2016)

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“…The patients were instructed on the use of these materials after standard care for periodontal diseases under the guidance of one dentist (T.M.). The process of manufacture of the tray have been described previously [ 23 ] and is described below.…”

Section: Methodsmentioning

confidence: 99%

Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial

et al. 2021

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Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, −0.1%; 95% confidence interval [CI], −1.0–0.8; P = 0.805) or test (mean increase, −0.3%; 95% CI, −1.1–0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, −0.00–0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, −0.01–0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, −0.2%; 95% CI, −1.4–0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, −0.00–0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).

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Study of the clinical usefulness of a dental drug system for selective reduction of mutans streptococci using a case series

Cited by 12 publications

References 21 publications

Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial

Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial

Effects of chlorhexidine (gel) application on bacterial levels and orthodontic brackets during orthodontic treatment

Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial

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