Study of the chromium binding in plasma of patients on continuous ambulatory peritoneal dialysis

Borguet, Frédérique; Cornelis, Rita; Delanghe, Joris; Lambert, Marie-Christine; Lameire, Norbert

doi:10.1016/0009-8981(95)06057-k

Cited by 39 publications

(21 citation statements)

References 9 publications

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“…However, if the ions are bound to proteins such as albumin or transferrin they will not be filtered by the kidney. There is evidence that Cr binds to both transferrin and to a lesser degree albumin in plasma, [38][39][40] which also explains the extended half-life of Cr in the body. Cr likely has a higher degree of protein binding, and hence the renal excretion is relatively low.…”

Section: Discussionmentioning

confidence: 99%

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Differential distribution of cobalt, chromium, and nickel between whole blood, plasma and urine in patients after metal‐on‐metal (MoM) hip arthroplasty

Newton

Ranganath

Armstrong

et al. 2012

Journal Orthopaedic Research

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Evidence shows that raised cobalt (Co), chromium (Cr), and nickel (Ni) whole blood concentrations correlate with poor device outcome in patients following metal-on-metal (MoM) hip arthroplasty. To understand the local and systemic pathological effects of these raised metal concentrations it is important to define their distribution between whole blood, plasma, and urine. The metals were measured by Inductively Coupled Plasma Mass Spectrometry (ICPMS). Two hundred and five plasma, 199 whole blood, and 24 sets of urine samples were analyzed from 202 patients with Co-Cr alloy MoM hip prostheses implanted between 8 months to 12 years (mean 6.0 years) prior to analysis. Plasma Co (median 39.1 nmol/L) showed significantly positive 1:1 correlation with whole blood Co (median 45.9 nmol/L; R 2 ¼ 0.98, p < 0.001, slope ¼ 1.0). Plasma Cr (median 53.8 nmol/L) and whole blood Cr (median 40.3 nmol/L) were also correlated; however, concentrations were significantly higher in plasma indicating relatively little blood cell uptake (R 2 ¼ 0.96, p < 0.001, slope ¼ 1.6). Urinary Co was up to threefold higher than Cr (median 334.0 vs. 97.3 nmol/L respectively). Nickel concentrations in whole blood, plasma, and urine were low relative to Co and Cr. The analysis shows fundamental differences in the physiological handling of these metals: Co is distributed approximately equally between blood cells and plasma, whereas Cr is mainly in plasma, despite which, Cr had far less renal excretion than Co.

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Section: Discussionmentioning

confidence: 99%

“…The laboratory participates in the Trace Elements External Quality Assessment Scheme (TEQAS). An octapole reaction system with helium collision gas was used to remove isobaric polyatomic interferences for Cr (e.g., 40 Ar 12 C, 36 Ar 16 O) and Ni (e.g. 44 Ca 16 O, 23 Na 37 Cl).…”

Section: Methods Sample Processing and Instrumentationmentioning

confidence: 99%

Differential distribution of cobalt, chromium, and nickel between whole blood, plasma and urine in patients after metal‐on‐metal (MoM) hip arthroplasty

Newton

Ranganath

Armstrong

et al. 2012

Journal Orthopaedic Research

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“…Metal ions may bind to specific serum proteins to form metal-protein complexes (Torti and Torti 1994, Borguet et al 1995, Sun et al 1999, BarOr et al 2001, Clodfelder et al 2001, Qian et al 2002, Eitinger et al 2005. Such metal-protein complexes produced from degradation of metal alloys are immunologically active in vitro (Hallab et al 2001).…”

Section: Metal-induced Immune Responsesmentioning

confidence: 99%

“…A sequence of 4 amino acids (N-Asp-Ala-HisLys) is indispensable for this binding (Bar-Or et al 2001). In serum, Cr 3+ can also bind to albumin, but it is still unclear whether this sequence of 4 amino acids plays a role in the uptake of Cr (Borguet et al 1995). Metal ions are also known to bind ferritin (Torti and Torti 1994).…”

Section: Metal Ions In Cellsmentioning

confidence: 99%

Metal-on-metal hip resurfacing arthroplasty: A review of periprosthetic biological reactions

et al. 2008

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“…It also binds other ions such as those of Al and Ga with reasonable affinity [58]. Chromium in serum of patients on peritoneal dialysis distributes mainly between transferrin and albumin in a time-dependent manner that may influence the kinetics of Cr(III) absorption from the dialysis fluid and the metabolism of Cr in the body [59].…”

Section: Macromolecular Compounds and Complexesmentioning

confidence: 99%

Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches (IUPAC Recommendations 2000)

Templeton

Ariese

Cornelis

et al. 2000

Pure and Applied Chemistry

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809

269

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Republication or reproduction of this report or its storage and/or dissemination by electronic means isAbstract: This paper presents definitions of concepts related to speciation of elements, more particularly speciation analysis and chemical species. Fractionation is distinguished from speciation analysis, and a general outline of fractionation procedures is given. We propose a categorization of species according to isotopic composition of the element, its oxidation and electronic states, and its complex and molecular structure. Examples are given of methodological approaches used for speciation analysis. A synopsis of the methodology of dynamic speciation analysis is also presented.

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Study of the chromium binding in plasma of patients on continuous ambulatory peritoneal dialysis

Cited by 39 publications

References 9 publications

Differential distribution of cobalt, chromium, and nickel between whole blood, plasma and urine in patients after metal‐on‐metal (MoM) hip arthroplasty

Differential distribution of cobalt, chromium, and nickel between whole blood, plasma and urine in patients after metal‐on‐metal (MoM) hip arthroplasty

Metal-on-metal hip resurfacing arthroplasty: A review of periprosthetic biological reactions

Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches (IUPAC Recommendations 2000)

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