Study of the bronchodilating effect of three doses of nebulized oxitropium bromide in asthmatic preschool children using the forced oscillation technique

Pauwels, Jochen; Desager, K N; Creten, W. L.; Veken, Jos Van der; Bever, Hugo P. Van

doi:10.1007/s004310050611

Cited by 8 publications

(3 citation statements)

References 14 publications

(12 reference statements)

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“…In placebo-controlled studies, FOT was useful to document therapeutic response to bronchodilators, such as theophylline, terbutaline, or ipratropium bromide (197)(198)(199)(200)(201)(202)(203)(204)(205)(206)(207). The criteria (and cutoff values) for diagnosis of meaningful reversibility postbronchodilation are reported in Table 9.…”

Section: Asthmamentioning

confidence: 99%

An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children

Beydon

Davis

Lombardi

et al. 2007

Am J Respir Crit Care Med

1,041

980

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on behalf of the American Thoracic Society/ European Respiratory Society Working Group on Infant and Young Children Pulmonary Function Testing This official statement of the American Thoracic Society (ATS) and the European Respiratory Society (ERS) was approved by the ATS Board of Directors, September 2006, and the ERS Executive Committee, December 2006 6. Further multidisciplinary work is required to investigate the best combination of tests (e.g., structure, function, inflammation, atopy) and challenges (e.g., pharmaceutical vs. physical) to investigate specific clinical entities during early childhood.

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Section: Asthmamentioning

confidence: 99%

An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children

Beydon

Davis

Lombardi

et al. 2007

Am J Respir Crit Care Med

1,041

980

View full text Add to dashboard Cite

show abstract

“…In young children, FOT has been shown to provide a useful and objective method to assess airway responses to bronchodilator drugs, such as metaproterenol, ipratropium bromide or salbutamol versus placebo [87][88][89][90], and to characterise dose/response curves [88,91]. For example, the bronchodilating effect of nebulised oxitropium bromide (750 and 1500 mg) in preschool asthmatic children was shown to last for up to 4 h postinhalation, whereas no additive bronchodilation by fenoterol could be shown [92] .…”

Section: Reversibilitymentioning

confidence: 99%

The forced oscillation technique in clinical practice: methodology, recommendations and future developments

Oostveen¹,

MacLeod²,

Lorino³

et al. 2003

European Respiratory Journal

1,059

1,120

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The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory mechanics. FOT employs small-amplitude pressure oscillations superimposed on the normal breathing and therefore has the advantage over conventional lung function techniques that it does not require the performance of respiratory manoeuvres.The present European Respiratory Society Task Force Report describes the basic principle of the technique and gives guidelines for the application and interpretation of FOT as a routine lung function test in the clinical setting, for both adult and paediatric populations.FOT data, especially those measured at the lower frequencies, are sensitive to airway obstruction, but do not discriminate between obstructive and restrictive lung disorders. There is no consensus regarding the sensitivity of FOT for bronchodilation testing in adults. Values of respiratory resistance have proved sensitive to bronchodilation in children, although the reported cutoff levels remain to be confirmed in future studies.Forced oscillation technique is a reliable method in the assessment of bronchial hyperresponsiveness in adults and children. Moreover, in contrast with spirometry where a deep inspiration is needed, forced oscillation technique does not modify the airway smooth muscle tone. Forced oscillation technique has been shown to be as sensitive as spirometry in detecting impairments of lung function due to smoking or exposure to occupational hazards. Together with the minimal requirement for the subject9s cooperation, this makes forced oscillation technique an ideal lung function test for epidemiological and field studies. Novel applications of forced oscillation technique in the clinical setting include the monitoring of respiratory mechanics during mechanical ventilation and sleep.

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“…The measured resistance of the respiratory system (Rrs) is most closely linked to airway resistance. FOT has been used in clinical trials to document response to bronchodilator inhalation (14,15) and anti-inflammatory administration (16) and has been found to be reproducible and to correlate with FEV 1 . (17) Unfortunately, in the CF preschool population, results have been variable in the ability to detect early disease.…”

Section: Forced Oscillation Techniquementioning

confidence: 99%

Challenges and Limitations of Testing Efficacy of Aerosol Device Delivery in Young Children

Goralski

Davis

2014

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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An increasing number of medical conditions are chronically or acutely managed with some form of aerosolized therapy. Due to the benefit of directly administering medications to the intended site of action, there is great interest in evaluating treatments for aerosol use. One of the major challenges in selecting and testing new drug-device combinations in children is the uncertainty regarding the appropriate outcome measure to choose. In studies involving adult patients, typically exacerbations of disease or airflow obstruction are assessed as endpoints in drug trials or device assessment. However, in young children, choosing endpoints to assess efficacy is difficult due to the potential lack of sensitive, noninvasive endpoints that are easily performed across sites. In this review, we discuss the challenges and limitations of selecting clinical endpoints for drug-device trials in the youngest population, with a focus on novel emerging technologies. This article provides an overview of preschool and infant pulmonary function testing, multiple-breath washout, imaging techniques including computed tomography and magnetic resonance imaging, flexible bronchoscopy in children, mucociliary clearance scans, and exhaled breath condensate.

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Study of the bronchodilating effect of three doses of nebulized oxitropium bromide in asthmatic preschool children using the forced oscillation technique

Cited by 8 publications

References 14 publications

An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children

An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children

The forced oscillation technique in clinical practice: methodology, recommendations and future developments

Challenges and Limitations of Testing Efficacy of Aerosol Device Delivery in Young Children

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