Study of the Biologically Active Properties of Medicinal Plant Cotinus coggygria

Abstract

The results of the studies have shown that to obtain an extract of a complex of biologically active substances of Cotinus coggygria, ethyl alcohol (mass fraction of alcohol 70%) with a hydromodule of 1:5 should be used, and the extraction should be carried out for 60 min at a temperature of 60 °C. The investigated plant extracts with the complex of bioactive substances from the Cotinus coggygria leaves and flowers are safe from the point of view of the content of heavy metals, pesticides, aflatoxin B1, radionuclides, as well as pathogenic and opportunistic microorganisms. It has been established that the Cotinus coggygria extract contains rutin, hyperoside, ferulic acid, quercetin, kaempferol, disulphuretin, sulphurein, sulphurein, gallic acid, methyl gallate, pentagalloyl glucose, 3,3′,4′,5,6,7-hexahydroxyflavonone, 3,3′,4′,5,5′,7-hexahydroxyflavonone, 3-O-α-L-rhamnofuranoside, 3,3′,4′,5,5′,7-hexahydroxyflavulium(1+), 7-O-β-D glucopyranoside, and 3,3′,4′,7-tetrahydroxyflavonone. The tested extracts have anticancer, antigenotoxic, and antimicrobial (against E. coli, S. aureus, P. vulgaris, C. albicans, L. mesenteroides) properties. The high antioxidant status of the tested extracts was established; the antioxidant activity of the samples was 145.09 mg AA/g (AA—ascorbic acid).

Chemical Composition and Content of Biologically Active Substances Found in Cotinus coggygria, Dactylorhiza maculata, Platanthera chlorantha Growing in Various Territories

“…Hassan et al [23] showed that C. coggygria is characterized by low oxalic acid content. Thus, the oxalic acid content in Cotinus coggygria [8] in our studies is 3.74 times lower than its content in D. maculata [7].…”

“…It was shown that samples of BAS complex extracts isolated from the studied medicinal plants from different regions (Table 9) had an inhibitory effect on the E. coli test strain. Lysis zone was from 13.6 to 16.5 mm, from 15.2 to 17.0 mm, and from 15.1 to 17.0 mm for C. coggygria [8], D. maculata [7], and P. chlorantha, respectively. Platanthera chlorantha samples from the Eastern Baltics exhibited high antibacterial activity against S. aureus (lysis zone 18.0 mm).…”

“…The study [22] demonstrated that C. coggygria contains 1.03% myricetin with a molecular weight of 318, 1.41% fisetin with a molecular weight of 303, 1.40% rutin with a molecular weight of 612, 0.09%, quercetin with a molecular weight of 338, and is 0.08% flavonoid with unknown structure [8]. The total percentage of D. maculata flavonoids was determined as 4.01% [7], and P. chlorantha 5.6%.…”

“…The chemical and spatial structures of secondary metabolites of medicinal plants are comparable to the metabolic products of microorganisms, which contributes to the fact that plant extracts of the BAS complex are more actively involved in biological processes [8]. In this regard, the biological activity (antioxidant and antimicrobial) of the complex of biologically active substances from the studied medicinal plants growing in the territory of the Eastern Baltic was studied.…”

“…C. coggygria extracts have high antioxidant activity in reaction with DPPH (IC 50 = 2.6 ± 0.4 and 3.8 ± 0.5 µg/mL, respectively) and can slow down and completely inhibit the plant lipid peroxidation [8]. Additionally, a plant extract from the Cotinus coggygria leaves and flowers has anti-cancer and antigenotoxic properties.…”