Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India

Abstract

A study of organ-specific and organ-nonspecific autoantibodies was carried out in 21 children being followed up after a diagnosis of Kawasaki disease at a tertiary care center of North India. Anti-nuclear antibodies were detected in 9.5% patients while anti-thyroid microsomal antibodies were detected in 23.9% patients. Other autoantibodies (e.g. anti-parietal cell antibody, anti-liver kidney microsomal antibody anti-neutrophil cytoplasmic antibody, anti-mitochondrial antibody and anti-smooth muscle antibody) were not detected in any of our patients. Children with Kawasaki disease need to be monitored for the development of autoantibodies during follow-up.

Kawasaki disease in a girl with turner syndrome: a remarkable association

“…Moreover, our recent data have emphasised a possible link between KD and other autoimmune disorders, indicating a higher incidence of coeliac disease than in the general population [4] and strengthening past data on the concurrence of autoantibodies in both the acute and the convalescent phases of KD, such as aCL [10,11], ANCAs [10], ANAs, and antithyroid microsomal antibodies [12]. …”

Autoantibody profile in children with Kawasaki disease on long‐term follow‐up: A prospective study from North India

“…This is associated with an increased release of cytokines, including interleukins (IL‐8, IL‐6 and tumour necrosis factor‐alpha [TNF‐α]) . Although KD is not considered to be an autoimmune disease, several autoantibodies have been demonstrated during the acute stage of KD that may persist during convalescence (Table ) . A few studies have also assessed these antibodies in patients with KD on short‐term follow up .…”

“…KD appears to be associated with immunological dysfunction as manifested by upregulation of the cytokine cascade in affected patients. In addition, several autoantibodies (organ specific as well as organ non‐specific) have also been closely associated with the pathogenesis of KD . However, the exact origin and pathogenic role of these antibodies in KD is poorly understood.…”

“…While several authors have reported on these autoantibodies during the acute and convalescent phase of KD, little is known about the long‐term follow up of such cases. In a previous study from our institute, the autoantibodies were assessed in children with KD at a minimum follow‐up of 3 months and at a mean follow‐up of 1.7 years . The present study was planned to assess the profile of autoantibodies on long‐term follow up of children with KD.…”

Kawasaki Disease in Dizygotic Twins in Turkey

“…No relationship between immune findings and cardiac involvement could be identified. In another study, in 21 children with KD, ANA were detected in 9.5% while antithyroid microsomal antibodies were positive in 23.9% of patients 8 . Suziki, et al showed positive immunoreactions to vascular walls of coronary arteries in 16 of 48 patients with KD 9 .…”