Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren

Giovaninni, Nayara P.; Fuly, Jeanne Teixeira Bessa; Moraes, Leonardo Iezzi de; Coutinho, Thais N.; Trarbach, Ericka Barbosa; Jorge, Alexander Augusto de Lima; Costalonga, Everlayny Fiorot

doi:10.1016/j.jped.2014.01.011

Cited by 13 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With regard to the minor allele (G) of rs1801260, several studies of this SNP in the general adult population and school-age children identified a similar effect as did the current study, which suggest the minor allele of rs1801260 is linked to higher BMI [10,14,15,23,24]. The minor allele of rs1801260 was related to the expression level of the CLOCK gene and consequently might affect the CLOCK-related obesogenic mechanism.…”

Section: Plos Onesupporting

confidence: 80%

“…Thus far, few studies have assessed the association of the CLOCK gene with obesity in the pediatric population. Giovaninni et al (n = 340) [ 23 ] and Valladares et al (n = 256) [ 24 ] both assessed the relationship of rs1801260 with BMI in school-age children. Although the association did not reach statistical significance, children who carried the minor allele had a higher rate of overweight and/or BMI z-scores in their studies.…”

Section: Discussionmentioning

confidence: 99%

“…We specified the simulation (n = 1000) with random effects for the intercept, fixed treatment effects and fixed effects for the genotypes. Previous studies indicated the difference of BMI z-scores between the C allele carriers and noncarriers of the CLOCK SNP was around 0.4, and the difference between the AA allele carriers and TT allele carriers of the FTO SNP ranged from 0.2 to 1.1 [ 23 – 25 , 39 ]. Therefore, we assumed a low effect size of 0.5 and a moderate effect size of 1 to conduct the power analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Since the CLOCK SNP, rs1801260, might be associated with BMI and weight loss intervention in adults, it potentially had similar effect in children. Giovaninni et al [ 23 ] and Valladares et al [ 24 ] assessed this SNP in school-age children, but the difference in BMI between minor allele carriers and non-carriers did not reach statistical significance.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

2020

View full text Add to dashboard Cite

Disruption of circadian rhythms and variations in the FTO gene may interfere with energy homeostasis and play a role in the development of obesity. The current study assessed the association of common polymorphisms in the CLOCK and FTO genes with standardized body mass index scores (BMI z-scores) and their potential modification of the impact of a culinary nutrition and physical activity intervention in school-age children. Anthropometric measurements were collected in 121 children at the baseline and one-year follow-up of a controlled trial of a school-based culinary nutrition and physical activity intervention. Genotypes of the CLOCK polymorphism (rs1801260) and the FTO polymorphism (rs9939609) were obtained from buccal swabs. Linear mixed-effects regression was applied to evaluate the genetic association and adjust for clusters within families and schools. In our participants, obesity affected 6.6% (8/121) of the children at the baseline and 6.4% (7/109) of the children at the follow-up. The associations between the age-and sex-adjusted BMI z-scores and the two polymorphisms did not reach statistically significance. Yet, sex potentially modified the association between rs1801260 and BMI z-scores. In girls, the G allele carriers had a higher BMI z-scores at the baseline and the follow-up. These polymorphisms did not modify the effect of our culinary nutrition and physical activity intervention on BMI z-scores. Sex is a potential modifier for the association between the CLOCK polymorphism, rs1801260, and BMI z-scores in school-age children. Further investigation is warranted to delineate the sex-dependent role of the CLOCK polymorphisms in the development of childhood obesity.

show abstract

Section: Plos Onesupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

2020

View full text Add to dashboard Cite

show abstract

“…The remaining 393 articles were read in full, with 281 excluded: 120 did not meet the age criteria (5‐13 years); 8 were of clinical or nonfree‐living population groups; 8 did not measure weight status objectively; 68 did not analyze the association between sleep‐obesity; and 77 were excluded either due to being non‐English, not peer‐reviewed, review/meta‐analysis, duplicate data, or a conference abstract/other unpublished data. This left 112 articles deemed relevant and included in the analysis (Table ) …”

Section: Resultsmentioning

confidence: 99%

Sleep and obesity among children: A systematic review of multiple sleep dimensions

et al. 2020

View full text Add to dashboard Cite

Summary The objectives were to systematically investigate the multiple dimensions of sleep and their association with overweight or obesity among primary school‐aged children. CINHAL, PsycINFO, SPORTDiscus, Medline, Cochrane, Embase, and PubMed databases were searched for papers reporting on an association between children's sleep and weight status. Studies on clinical populations, published in languages other than English, without objectively measured weight status, or where weight status was reported outside the outlined age bracket (5‐13 years) were excluded. A total of 34 248 citations were extracted from our systematic search protocol, of which 112 were included for detailed review. Compared with sleep duration, of which 86/103 articles found a significant inverse association between sleep duration and measured weight status, few studies examined other dimensions of sleep, such as quality, efficiency and bed/wake times, and relationship with weight status. Where studies existed, variation in defining and measurement of these dimensions restricted comparison and potentially influenced discrepancies across results. Overall, the findings of this review warrant the need for further research of the outlined dimensions of sleep. Future research would benefit from clarity on definitions across the different dimensions, along with the use of valid and reliable tools.

show abstract

Genetic Studies of Sleep in Children

Mitchell,

Cielo

2024

Genetics of Sleep and Sleep Disorders

View full text Add to dashboard Cite

Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren

Abstract: The CLOCK 3111T/C polymorphism was not significantly associated with overweight or sleep duration in children in this city.

Cited by 13 publications

References 29 publications

Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

Sleep and obesity among children: A systematic review of multiple sleep dimensions

Genetic Studies of Sleep in Children

Contact Info

Product

Resources

About