Study of the Association Between Polymorphisms of the COL1A1 Gene and HBV-Related Liver Cirrhosis in Chinese Patients

Zhao, Yunpeng; Wang, Hao; Fang, Meng; Ji, Qiang; Yang, Zaixing; Gao, Chunfang

doi:10.1007/s10620-008-0340-9

Cited by 9 publications

(6 citation statements)

References 35 publications

(45 reference statements)

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“…Given the progressive up regulation of COL1A1 in human liver and gastric cancers [ 8 ], we investigated how COL1A1 influences cellular process by genetically manipulating the expression of COL1A1 in CaSki and Hela cells. COL1A1 knock down and COL1A1 activation cell models were constructed.…”

Section: Resultsmentioning

confidence: 99%

“…Collagen type I alpha 1 (COL1A1) is a member of group I collagen which include COL1A1 and COL1A2 [ 7 ]. Collagen is the main protein of bones, tendons and teeth, and involved in tumor cell adhesion, gap junction and extracellular matrix (ECM) [ 8 – 10 ]. Previous studies have reported that COL1A1 is upregulated in gastric cancer, and plays important roles in cancer cell invasion and metastasis in this cancer [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells

Liu

Liao

2017

Cancer Cell Int

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BackgroundCervical cancer is a common cancer of women in developing countries, and radiotherapy still remains its predominant therapeutic treatment. Collagen type I alpha 1 (COL1A1) has been shown to have a radioresistance effect in previous studies. However, such effect of COL1A1 has not yet been revealed in cervical cancer.MethodsExpression of COL1A1 in cervical cancer tissues and normal tissues was assessed by qRT-PCR and immunohistochemistry. The effect of COL1A1 on radioresistance of human cervical cancer cell lines HeLa and CaSki was assessed using the colony formation assay. Apoptosis alterations were analyzed by flow cytometry. In addition, western blotting was used assessed the alterations of several critical apoptosis and signaling pathway related proteins.ResultsThe expression of COL1A1 was significantly increased in cervical cancer tissues compared with normal tissues at the mRNA and protein level. Further, based on COL1A1 knock down and COL1A1 activation cell models, a negative correlation was observed between COL1A1 expression level and radiosensitivity. Moreover, the findings are further supported by apoptosis analysis that COL1A1 activation could inhibit the apoptosis of cervical cancer cells. Subsequently, a significantly decreased expression of p-AKT and Bcl-2, increased expression of Caspase-3 were observed in the LY294002 plus radiation group compared with radiation alone group, while these influences caused by LY294002 or X-ray radiation were reversed after COL1A1 activation.ConclusionsTo our knowledge, this is the only study to profile the mechanisms that COL1A1 plays a crucial role in cervical cells anti-apoptosis induced by radiation. Therefore, our identification of radioresistance-related COL1A1 in cervical cancer could be a starting point to explore the function of collagens, adding a new dimension to our understanding of the cervical cancer, assisting cancer biologists and clinical oncologists in novel therapeutic strategies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12935-017-0443-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells

Liu

Liao

2017

Cancer Cell Int

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“…COL1A1 has been demonstrated to be upregulated in liver fibrosis by the activation of stellate cells and the progression of liver fibrosis. [ 26 , 27 ] Zhao et al [ 28 ] showed that COL1A1 gene polymorphism was associated with liver fibrogenesis, since the T allele at 1997 of COL1A1 was crucial to the increased transcriptional activity. COL1A2 is an independent predictor of survival in diseases.…”

Section: Discussionmentioning

confidence: 99%

Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis

Wang

et al. 2017

Medicine

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“…COL1A1 and COL1A2 are associated with liver fibrogenesis [26], [27]. Moreover, COL1A2 is involved in the development or progression of hepatoma [22].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Analysis of the Dynamic Biological Networks in HCV Induced Hepatocarcinogenesis

Zhang

Shi

2011

PLoS ONE

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Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, which is closely related to hepatitis C and cirrhosis. The molecular mechanisms underlying the hepatocarcinogenesis induced by HCV infection remain clarified from a standpoint of systems biology. By integrating data from protein-protein interactions, transcriptional regulation, and disease related microarray analysis, we carried out a dynamic biological network analysis on the progression of HCV induced hepatocarcinogenesis, and systematically explored the potentially disease-related mechanisms through a network view. The dysfunctional interactions among proteins and deregulatory relationships between transcription factors and their target genes could be causes for the occurrence and progression of this disease. The six pathologically defined disease stages in the development and progression of HCC after HCV infection were included in this study. We constructed disease-related biological networks for each disease stage, and identified progression-related sub-networks that potentially play roles in the developmental stage of the corresponding disease and participate in the later stage of cancer progression. In addition, we identified novel risk factors related to HCC based on the analysis of the progression-related sub-networks. The dynamic characteristics of the network reflect important features of the disease development and progression, which provide important information for us to further explore underlying mechanisms of the disease.

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Study of the Association Between Polymorphisms of the COL1A1 Gene and HBV-Related Liver Cirrhosis in Chinese Patients

Cited by 9 publications

References 35 publications

Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells

Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells

Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis

A Comprehensive Analysis of the Dynamic Biological Networks in HCV Induced Hepatocarcinogenesis

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