Study of the Antioxidant Property and Xanthine Oxidase Inhibitory Activity of Various Extracts from the Algerian Medicinal Plant Paronychia argentea L.

Abstract

Introduction: Paronychia argentea L. is used in traditional medicine to treat various diseases in Algeria especially kidney stones. This study was focused on the antioxidant and xanthine oxidase inhibitory activities of these plant extracts. Methods: The different extracts were prepared using solvents of increasing polarity, and their total polyphenols and flavonoids contents were determined using spectrophotomet ric methods. The antioxidant activities of Paronychia argentea extracts (PAE) were assessed by their inhibitory effect on xanthine oxidase (XO) and their scavenger ability on superoxide radical (O 2•-) generated by this enzyme. Results: The analysis PAE showed that ethyl-acetate extract (EaE) has the highest concentration of total phenolics and flavonoids compared with the chloroform extract (ChE) and the crude extract (CE). Results revealed that all PAE were effective in both XO inhibiting and superoxide radical scavenging, with the following order for the two assays: ChE > EaE > CE. Conclusion: This study provided evidence that PAE had interesting antioxidant potential which was confirmed using two enzymatic methods. Therefore, this plant could be used to treat gout and lot of diseases, where inhibition of XO and scavenging of superoxide radical are necessary.

Tracking Growth, Biochemical Responses, and Ion Uptake in Paronychia Argentea Micro Plants Grown in Vitro under Salinity Induced Environment

“…This herb is reported to contain many secondary metabolites like flavonoids including mainly Isorhamnetin, Quercetins, and luteolin (Adjadj and Djarmouni, 2018). Quercetins is considered as the main type of flavonoids (Bors, et al 1990), that have many biological functions including protecting against lipid peroxidation, anticancerous, anti-inflammatory actions, and antioxidant benefits (Arya, et al, 2008) Isorhamnetin is naturally presented in different kinds of plants and has many biological functions including anti-inflammatory and oxidation activities and it can decrease cancer risk and control the growth of many kinds of cancer (Zuo, et al 2011).…”

“…P. argentea is popularly known as Arabic tea and is commonly used in folk medicine in the region (Adjadj and Djarmouni, 2018) for the treatment of bladder and prostate diseases, and abdominal ailments (Bouanani et al, 2010) in addition to kidney stones, diabetes and heart pains (Afifi et al, 2005).…”