The analysis of the main and micro-impurity elemental composition of fragments of antique amphorae with features and stamps of the Knidos and Kos centers of production has been carried out. Differences in the groups of samples from Kos and Knidos have been detected in terms of the Si and Fe content, which can be considered as evidence of different technological characteristics. Specifically, the high concentration of quartz/silica sand in the clay of the amphorae produced in Kos and the use of iron-rich clay in the products of Knidos should be noted. Statistical analysis indicated the stratification of the samples according to the main elements and impurities (Al, Si, Ca, Mg, Fe, K, Ti) into 3 groups Kos and two groups of Knidian samples typical for the island (Kos) and continental (Knidos) origin of the samples.