Study of the anaerobic corynebacteria

Zierdt, Charles H.; Webster, Charles; Rude, Willadene S.

doi:10.1099/00207713-18-1-33

Cited by 44 publications

(41 citation statements)

References 8 publications

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“…They have the morphology of siphoviruses, consisting of a~50 nm icosahedral head and ã 150 nm flexible tail (Farrar et al, 2007). Zierdt et al, (1968) isolated phage 174 from spontaneous plaques of a P. acnes isolate. Phage 174 was able to lyse nearly all P. acnes strains tested in the study.…”

Section: Introductionmentioning

confidence: 99%

The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin

et al. 2015

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The viral population, including bacteriophages, is an important component of the human microbiota, yet is poorly understood. We aim to determine whether bacteriophages modulate the composition of the bacterial populations, thus potentially playing a role in health or disease. We investigated the diversity and host interactions of the bacteriophages of Propionibacterium acnes, a major human skin commensal implicated in acne pathogenesis. By sequencing 48 P. acnes phages isolated from acne patients and healthy individuals and by analyzing the P. acnes phage populations in healthy skin metagenomes, we revealed that P. acnes phage populations in the skin microbial community are often dominated by one strain. We also found phage strains shared among both related and unrelated individuals, suggesting that a pool of common phages exists in the human population and that transmission of phages may occur between individuals. To better understand the bacterium-phage interactions in the skin microbiota, we determined the outcomes of 74 genetically defined Propionibacterium strains challenged by 15 sequenced phages. Depending on the Propionibacterium lineage, phage infection can result in lysis, pseudolysogeny, or resistance. In type II P. acnes strains, we found that encoding matching clustered regularly interspaced short palindromic repeat spacers is insufficient to confer phage resistance. Overall, our findings suggest that the prey-predator relationship between bacteria and phages may have a role in modulating the composition of the microbiota. Our study also suggests that the microbiome structure of an individual may be an important factor in the design of phage-based therapy.

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Section: Introductionmentioning

confidence: 99%

The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin

et al. 2015

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“…Several workers are of the opinion that some of the anaerobic species described by Prbvot (1966), e.g., C. anaerobium, C. avidum, C. diphtheroides, C. granulosum, C. liquefaciens, C. Iymphophilum and C. parvum should be re-classified as C. acnes (Zierdt, Webster and Rude, 1968;Moss et a/., 1969;Reid and Joya, 1969). Others disagree with this view (Moore, Holdeman and Cummins, 1968), and some consider that the C. acnes species contains two distinct groups of organisms (Brzin, 1964;Voss, 1970).…”

Section: D~scussro~mentioning

confidence: 99%

Lympho-Reticular Stimulatory Properties of Corynebacterium Parvum and Related Bacteria

Adlam

Scott

1973

Journal of Medical Microbiology

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“…The descriptions of previous investigat o r s (Tabie 11) disagree over many of the reactions for each species. This is probably explained by the observations of Zierdt et al (1968) who pointed out that biochemical reactions might vary with size of inoculum and type of media, and with repeated subculture.…”

Section: Discussionmentioning

confidence: 87%

“…Table I1 gives the characteristics found by previous investigators: Douglas and Gunter (1946); Prgvot (1957Prgvot ( ,1966; King and Meyer (1957); Bouisset et al (1963); Brzin (1964); Dowell, Lewis and Schekter (1967); Zierdt --et al (1968) and Puhvel (1968).…”

Section: Resultsmentioning

confidence: 93%

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A study of the morphologic and biochemical characteristics of certain anaerobic corynebacteria

Reid

Joya

1969

International Journal of Systematic Bacteriology

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T h e b i o c h e m i c a l r e a c t i o n s , a n t ib i o t i c s e n s i t i v i t i e s , p h a g e s u s c e p t i b i l i t y a n d m o r p h o l o g i c f e a t u r e s o f n i n e a n a e r o b i c c o r yn e b a c t e r i a , o b t a i n e d f r o m t h e A m e r i c a n T y p e C u l t u r e C o l l e c t i o n a n d D r . A-R P r g v o t ( i d e n t if i e d i n t h e s e c o l l e c t i o n s a s C o r y n e b a c t e r i u m a c n e s , C . a n a e r o b i u m , C . a v i d u m , C . d i p ht h e r o i d e s , C . g r a n u l o s u m , C . --l i q u e f a c i e n s , C. l y m p h o p h i l u m , C . p a r v u m a n d C . p y o g e n e s ) w e r e e x a m i n e d o v e r a n 1 8 m o n t h p e r i o d . M a n y b i o c h e m i c a l c h a r a c t e r i s t i c s v a r i e d on r e p e a te d e x a m i n a t i o n . A l l o r g a n i s m s w e r e h i g h l y s e n s i t i v e t o 7 a n t i b i o t i c s a n d a l l b u t o n e o f t h o s e t e s t e d w e r e s u s c e p t i b l e t o a s i n g l e p h a g e . S i z e a n d m o r p h o l o g y v a r i e d u n d e r d i ff e r e n t c o n d i t i o n s . R e v i e w o f t h e l i t e r a t u r e s h o w e d m u c h d i s a g r e e m e n t o n t h e c h a r a c t e ri s t i c s of e a c h o r g a n i s m . I t w a s c o n c l u d e d t h a t c o n v e n t i o n a l r o u t i n e m e t h o d s d o n o t p e rm i t t h e i r r e c o g n i t i o n a s i n d i v i d u a l s p e c i e s , a n d t h a t t h e y s h o u l d b e r e g a r d e d a s v a r i a n t s ---

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Study of the anaerobic corynebacteria

Cited by 44 publications

References 8 publications

The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin

The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin

Lympho-Reticular Stimulatory Properties of Corynebacterium Parvum and Related Bacteria

A study of the morphologic and biochemical characteristics of certain anaerobic corynebacteria

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