Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro

Krivorutchenko, Yu. L.; Andronovskaja, I. B.; Hinkula, Jorma; Krivoshein, Yuri S.; Ljungdahl-Ståhle, E; Pertel, Sergey S.; Гришковец, В. И.; Zemlyakov, A. E.; Wahrén, Britta

doi:10.1016/s0264-410x(97)00065-0

Cited by 22 publications

(10 citation statements)

References 34 publications

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“…Some of the new synthetic MDP derivatives (pbutyI-MDP, MTPO-26i~-cholesteroI-MD) and one saponin (Taurosid 1) have been shown to induce strong humoral immune response to HIV-1 envelope glycoproteins rgp 160 and rgp 120. (54). In one of our studies on the env and gag peptides of HIV, high antibody titres were obtained with peptides entrapped in liposomes alongwith MDP analog (MA729).…”

Section: Glycoproteins and Peptides Of Microbial Originmentioning

confidence: 97%

New age adjuvants and delivery systems for subunit vaccines

Koduri

Manocha

Sabhnani

et al. 2000

Indian J Clin Biochem

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The dramatic advancements in the field of vaccinology has led to the formulation of chemically well defined vaccines composed of synthetic peptides and recombinant proteins derived from the immunologically dominant regions of the pathogens. Though these subunit vaccines are safer compared to the traditional vaccines they are known to be poorly immunogenic. This necessitates the use of adjuvants to enhance the immunogenicity of these vaccine formulations. The most common adjuvant for human use is alum. Research in the past has focused on the development of systemic immunity using conventional immunization protocols. In the present era, the emphasis is on the development and formulation of alternative adjuvants and delivery systems in generating systemic as well as mucosal immunity. This review mainly focuses on a variety of adjuvants (particulate as well as non-particulate) used with protective antigens of HIV, malaria, plague, leprosy using modified delivery vehicles. The experience of our laboratory and other researchers in this field clearly proves that these new age adjuvants and delivery systems undoubtedly generate enhanced immune response -both humoral and cell mediated. The choice of antigens, the nature of adjuvant used and the mode of delivery employed have a profound effect on the type of immune response generated. Besides the quantity, the quality of the antibodies generated also play a vital role in protection against these diseases. Some of the adjuvants and delivery systems used promoted high titre and affinity antibodies, which were shown to be cytophilic in nature, an important criteria in providing protection to the host. Thus the studies on these adjuvants/ delivery systems with respect to various infectious diseases indicate their active role in efficient modulation of immune response along with safety and permissiblity.

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Section: Glycoproteins and Peptides Of Microbial Originmentioning

confidence: 97%

New age adjuvants and delivery systems for subunit vaccines

Koduri

Manocha

Sabhnani

et al. 2000

Indian J Clin Biochem

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“…They revealed that MDP and other muramylpeptides of an appropriate size and structure provoked the necrotic reaction, while PGM and other bacterial immunomodulators, which shared many bioactivities with muramypeptides, did not [44]. Numerous MDP variants have been developed to overcome limitations of toxicity, but retaining adjuvant effects [5][6][7][8][9][10][11][12]. Reports mostly agree that all synthesized derivates of MDP could be useful immunoadjuvants.…”

Section: Experimental Groupsmentioning

confidence: 99%

“…A variety of MDP analogs and derivatives have also been synthesized and their adjuvant activities have been examined [5][6][7][8][9][10][11][12]. MDP and its derivates are now known to be PAMPs [13].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of structurally related peptidoglycan monomer and muramyl dipeptide on humoral IgG immune response to ovalbumin in mouse

Habjanec

Halassy

Tomašić

2010

International Immunopharmacology

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“…At the present, saponins International Immunopharmacology 6 (2006) 1729 -1735 www.elsevier.com/locate/intimp extracted from the bark of the South American tree Quillaja saponaria Molina have been used as an adjuvant to increase the immune responses to a variety of antigens [4,5]. Recently, the immunomodulating activity of saponins from other sources has been investigated, such as seeds of Chenopodium quinoa (quinoa) [6], leaves of the plant Hedera taurica (Crimean ivy) [7], Panax ginseng [8], Panax notoginseng [9], and Polygala senega [10]. Acacia concinna (Leguminosae), a well-known medicinal plant of Southeast Asia, is commonly known as Sompoi in Thailand.…”

Section: Introductionmentioning

confidence: 99%