Study of some improved shellac derivatives as microencapsulating materials

Sheorey, D. S.; Kshirsagar, M. D.; Dorle, A. K.

doi:10.3109/02652049109069564

Cited by 11 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several approaches had been made to improve shellac stability and aqueous solubility. These approaches were the preparation in pseudo latex aqueous solution (9,10), the modification into shellac derivatives (11,12), and the preparation of shellac in ammonium salt form (4,8,13). Of all these attempts, the use of ammonium salt could improve the problem of stability to some extent, however, further investigation is needed to verify the application of salt form.…”

Section: Introductionmentioning

confidence: 99%

Effect of Salts and Plasticizers on Stability of Shellac Film

Luangtana‐anan

Limmatvapirat

Nunthanid

et al. 2007

J. Agric. Food Chem.

View full text Add to dashboard Cite

The aim of this study was to increase the stability of shellac because of the polymerization. A few approaches have been applied in this study. Shellac film was prepared in two salt forms, that is, ammonium and 2-methyl-2-amino 1-propanol salts, and a comparison was made with shellac film in free acid form. The other approach was by the application of plasticizers. These plasticizers were diethyl phathalate, triacetin, and polyethylene glycol 400 (PEG 400). Plasticized shellac and unplasticized shellac films in free acid form were then compared. All shellac films were kept in stability chamber at 40 degrees C, 75% RH for a period of 3 months. The studied parameters such as insoluble solid, acid value, mechanical properties, and water vapor permeability were detected every month. Analysis of variance (ANOVA) technique was used to analyze data. The applications of salt forms proved statistically significant (p < 0.01) to reduce the polymerization process whereas certain plasticizers could enhance the stability. PEG 400 was the only plasticizer that could show the increase in stability. The improvement of stability might be a result of the interference of a larger molecule of PEG 400 causing the difficulty in interaction among carboxyl or hydroxyl groups of shellac and the effect of lower loss of plasticizer.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Salts and Plasticizers on Stability of Shellac Film

Luangtana‐anan

Limmatvapirat

Nunthanid

et al. 2007

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Salicylic acid granules coated with chemically modified shellac exhibit improved flow and anti-aging properties. However, in addition to shellac-myristic acid derivatives, shellac-succinic anhydride, -phthalic anhydride, and -ethylenediamine derivatives, unfortunately, increase the moisture absorption of the salicylic acid granules …”

Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

“…However, in addition to shellac-myristic acid derivatives, shellac-succinic anhydride, -phthalic anhydride, and -ethylenediamine derivatives, unfortunately, increase the moisture absorption of the salicylic acid granules. 122 Notably, the introduction of additives, such as HPMC, into single-layer shellac-based coatings is another simple and efficient method of adjusting their performance. 123 Pellets coated with ethyl cellulose and shellac could greatly prolong the release time of ketoprofen, compared with pellets using ethyl cellulose and shellac as a binder.…”

Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

Yuan

Dong

et al. 2021

ACS Nano

View full text Add to dashboard Cite

Delivery systems play a crucial role in enhancing the activity of active substances; however, they require complex processing techniques and raw material design to achieve the desired properties. In this regard, raw materials that can be easily processed for different delivery systems are garnering attention. Among these raw materials, shellac, which is the only pharmaceutically used resin of animal origin, has been widely used in the development of various delivery systems owing to its pH responsiveness, biocompatibility, and degradability. Notably, shellac performs better on encapsulating hydrophobic active substances than other natural polymers, such as polysaccharides and proteins. In addition, specially designed shellac-based delivery systems can also be used for the codelivery of hydrophilic and hydrophobic active substances. Shellac is most widely used for oral administration, as shellac-based delivery systems can form a compact structure through hydrophobic interaction, protecting transported active substances from the harsh environment of the stomach to achieve targeted delivery in the small intestine or colon. In this review, the advantages of shellac in delivery systems are discussed in detail. Multiscale shellac-based delivery systems from the macroscale to nanoscale are comprehensively introduced, including matrix tablets, films, enteric coatings, hydrogels, microcapsules, microparticles (beads/spheres), nanoparticles, and nanofibers. Furthermore, the hotspots, deficiencies, and future perspectives of shellac-based delivery system development are also analyzed. We hoped this review will increase the understanding of shellac-based delivery systems and inspire their further development.

show abstract

“…[6,7] Recently, there have been many attempts to use shellac in controlled drug delivery systems due to its low water permeability, biodegradability, and low toxicity. [14,15] All these attempts could improve the problem of stability to some extent, and yet the solubility at intestinal pH still remained. These approaches are preparation in pseudolatex aqueous solution, [12,13] preparation of shellac in ammonium salt form, [5] and its modification into shellac derivatives.…”

Section: Introductionmentioning

confidence: 99%

Effect of Alkali Treatment on Properties of Native Shellac and Stability of Hydrolyzed Shellac

Limmatvapirat

Nunthanid

Luangtana‐anan

et al. 2005

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

The objective of this study was to investigate the effect of alkali treatment on properties of shellac. The native shellac was treated with sodium hydroxide for 15, 30, and 60 min to obtain hydrolyzed shellac. All types of shellac, namely native and hydrolyzed shellac at various times of treatment, were then prepared in films as free acid and ammonium salt forms by using ethanol and ammonium hydroxide solution, respectively. The results showed that alkali treatment caused an increase in acid value and a decrease in ester value. This is due to higher free carboxylic and hydroxyl groups caused by ester bond breaking. The longer the alkali treatment the higher impact of bond breaking, therefore, causing an increase in acid value, solubility at pH 7, strain, a decrease in ester value, water vapor permeability coefficient, and stress. The films were then kept at 40 degrees C, 75% RH for a period of three months. The aging effect led to an esterification of free carboxylic and hydroxyl groups, resulting in the significant change of acid value, ester value, and insoluble solid for both native and hydrolyzed shellac films in acid form. On the other hand, all types of shellac films in ammonium salt form exhibited a reasonable stability in physicochemical and mechanical properties as all films were protected from the esterification due to the formation of ammonium salt at the carboxylic binding site. It could be concluded that alkali treatment could produce hydrolyzed shellac with higher solubility in the intestine, the stability was yet in dilemma unless the shellac was in an ammonium salt form. The result obtained could, thus, provide a guideline in the use of shellac.

show abstract

Study of some improved shellac derivatives as microencapsulating materials

Cited by 11 publications

References 2 publications

Effect of Salts and Plasticizers on Stability of Shellac Film

Effect of Salts and Plasticizers on Stability of Shellac Film

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

Effect of Alkali Treatment on Properties of Native Shellac and Stability of Hydrolyzed Shellac

Contact Info

Product

Resources

About