Study of some aspects of autoimmune response for patients of thyroiditis

Kadhum, Eman Wahab; Hassan, Alaa Jawad

doi:10.9790/3008-09620104

Cited by 2 publications

(4 citation statements)

References 14 publications

(20 reference statements)

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“…In the presented study, the results revealed significant differences in level of auto-antibodies TPO to the thyroid gland in patients with Graves' hyperthyroidism (70.4%) as compared with non-autoimmune hyperthyroidism and healthy control group (0.0%). And this results were in agreement with a recent local study in Iraq (8,10) . Other studied in Sudan byElmugadamet al,presented that the Anti-TPO antibody was positive in 66.7%of Graves' disease patients compared to 5% of control group, and 17.5% in patients with non-autoimmune hyperthyroidism disease (4) .…”

Section: Figure (1)supporting

confidence: 94%

“…Similar observation was reported by (9) ,they presented that the age of patients with hyperthyroidism was (15-61) years (38.63±10.03). The presented dataalso agreed with (10) , that the ratio of incidence was increased in females compared with males in all age groups. The lower mean age among Iraq patients probably was due to the fact that the life spans of Iraqi patients were lower than that of European population.…”

Section: Figure (1)supporting

confidence: 88%

“…Thyroid autoantibodies are the markers of autoimmunity in autoimmune thyroid diseases (20,4) . Graves' hyperthyroidism disease which is an autoimmune disease where the antibodies to the thyroid stimulating hormone receptor (TSHR) make the thyroid gland produce too much hormone (10) . TSHR autoantibodies play a direct role in the pathogenesis of AITD.…”

Section: Figure (1)mentioning

confidence: 99%

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The Relation Between Thyroid Function and Auto-Antibodies in Graves' Disease and Non-Autoimmune Hyperthyroidism Disease in AL-Najaf Province

Nadhaif

Al-Saadiprof

Al-Jibouri

2015

Kufa Jour. Nurs. Sci.

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Objectives: The aim of presented study was evaluated the role of some immunological parameter associated with Graves' disease and comparison that with other non-autoimmune hyperthyroidism, by the following objectives: (1) measurement T3, T4 and TSH. (2) Evaluation of Anti-TSHR-antibody. (3) Estimation Anti-TPO antibody. Methodology: A case control study included patients with early diagnosis with thyrotoxicosis. Whole blood samples were collected of 73 cases in hormonal unite at Al-Sadder Medical City, Najaf, Iraq, in the period between May, 2011 to Oct., 2011. Out of the 73 hyperthyroidism patients, there were 48 females and 25 males, the patients' age range was between (15-50) years. All patients with hyperthyroidism under treatment and pregnant women excluded of the study. Statistical analysis was done by using SPSS version 20 in which include the followings: (1) ANOVA (analysis of variance) and LSD test (F-test). (2) persons correlation (r), coefficient for measurement data. Results: According to the results of this study, the female: male ratio (2.17:1) in GD patients and (1.37:1) with non-autoimmune hyperthyroidism group, which detects more frequent in females (68.5% and 57.9%, respectively) than males (31.5% and 42.1%, respectively). The age group between (36-50) years with GD it is the most vulnerable age group was recorded (66.7%), followed (26-35) years age group (20.4%) and (13.0%) in age group (15-25) years. However, hormonal tests (T3, T4 and TSH) levels were highly significant difference (P<0.001) between GD patients and other groups (non-autoimmune hyperthyroidism and healthy control). Furthermore, the levels of Anti-TSHR antibodies were highly significant between GD patients (P<0.001), and both non-autoimmune hyperthyroidism patient and healthy control, while there was no significant difference between non-autoimmune hyperthyroidism and healthy control groups (P>0.05). Additionally, the serum levels of thyroid peroxidase (TPO) was a highly significant difference between GD patients and (non-autoimmune hyperthyroidism and health control) (P<0.01), while no significant difference between non-autoimmune hyperthyroidism and healthy control P>0.05). Anti-TSHR antibodies have a highly significant positive correlation (P<0.01) with (T3 and T4) hormones (0.583 and 0.536, respectively) and a highly significant (P<0.01) but negative correlation with TSH hormone (-0.475). Conclusion: Anti-TSHR antibodies assay is helpful in diagnosis of autoimmune GD, as they can be detected very early in AITD. They may predict the eventual development into AITD when founded in making them a good diagnostic marker. Recommendation: For adults, the best recommendation may be to put thyroid function testing (TSH, T4, T3) on your list of health care provider.

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Section: Figure (1)supporting

confidence: 94%

Section: Figure (1)supporting

confidence: 88%

Section: Figure (1)mentioning

confidence: 99%

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