Study of Single Dose of Antibiotic Prophylaxis in Clean Surgeries at a Tertiary Care Centre

Abstract

Background: Pre-operative single dose antibiotic prophylaxis has shown to reduce the incidence of surgical site infections and thereby patient morbidity. Aims: To evaluate effectiveness of single dose antibiotic prophylaxis in clean surgeries at a tertiary care hospital. Material and Methods: A total of 72 patients undergoing clean surgeries were included after they satisfied the inclusion and exclusion criteria. Results: Single dose of an intravenous prophylaxis of ceftriaxone in clean surgeries excisional biopsy of lipoma, dermoid cyst, sebaceous cyst, enucleation of fibroadenoma, herniotomy, eversion of hydrocele etc. was efficacious in preventing surgical site infection. Surgical site infection was associated with patient’s age, lower haemoglobin levels and longer hospital stay in 3 out of 72 patients. Conclusion: In the present study it was observed that prophylactic single shot of antibiotic is efficacious in averting surgical site infection and is economical for patients undergoing clean surgeries. Factors associated with surgical site infection were patient’s age, haemoglobin and associated co-morbidity like diabetes.

A Point Prevalence Survey of Antimicrobial Use at Geita Regional Referral Hospital in North-Western Tanzania

“…It was also reported previously that over 50% of patients using antibiotics for surgical prophylaxis received multiple antibiotic agents for more than three days [11]. This practice is, however, not in compliance with clinical practice guidelines for antimicrobial use for surgical prophylaxis, which recommend a single dose immediately before surgery, as documented previously by multiple studies [29][30][31]. From these observations, it is recommended that an antimicrobial stewardship team and program be established to implement the effective monitoring and optimization of antibiotic use at GRRH in compliance with local and national standard treatment guidelines.…”